(E,4Z)-4-[4-ethenyl-1-(4-methylphenyl)sulfonylpyrrolidin-3-ylidene]-4-phenylbut-2-enenitrile | 1344999-87-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E,4Z)-4-[4-ethenyl-1-(4-methylphenyl)sulfonylpyrrolidin-3-ylidene]-4-phenylbut-2-enenitrile
• CAS: 1344999-87-6
• 化学式: C₂₃H₂₂N₂O₂S
• 分子量: 390.506
• InChiKey: PTAQBGSATNGNHW-CRIMBBNDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  69.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(4-bromobut-2-en-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 、 丙烯腈 在 palladium diacetate 、 potassium carbonate 、 三苯基膦 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 20.5h， 以76%的产率得到(E,4Z)-4-[4-ethenyl-1-(4-methylphenyl)sulfonylpyrrolidin-3-ylidene]-4-phenylbut-2-enenitrile
  参考文献：
  名称：

  Construction of 3-allylidene-4-vinyltetrahydrofurans and 3-allylidene-4-vinylpyrrolidines via sequential domino allylation/olefination of C–C triple bonds

  摘要：

  An efficient method via sequential domino allylation/olefination of C-C triple bonds for the syntheses of five-membered heterocycles was developed by treatment 1,6-enynes with alkenes in the presence of a palladium catalyst. The configurations of the 1,3-dienes of the five-membered heterocycles are stereocontrolled. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.026

文献信息

• Construction of 3-allylidene-4-vinyltetrahydrofurans and 3-allylidene-4-vinylpyrrolidines via sequential domino allylation/olefination of C–C triple bonds
  作者：Tuan-jie Meng、Yimin Hu、Quansheng Zhao、Tao Yu、Shaowu Wang

  DOI：10.1016/j.tet.2011.09.026

  日期：2011.11

  An efficient method via sequential domino allylation/olefination of C-C triple bonds for the syntheses of five-membered heterocycles was developed by treatment 1,6-enynes with alkenes in the presence of a palladium catalyst. The configurations of the 1,3-dienes of the five-membered heterocycles are stereocontrolled. (C) 2011 Elsevier Ltd. All rights reserved.