6-(Methylthio)hexanoic acid | 54293-06-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-(Methylthio)hexanoic acid
• 英文别名: 6-methylthio-hexanoic acid；Hexanoic acid, 6-(methylthio)-；6-methylsulfanylhexanoic acid
• CAS: 54293-06-0
• 化学式: C₇H₁₄O₂S
• 分子量: 162.253
• InChiKey: IXKKFBLONLRKMR-UHFFFAOYSA-N

物化性质

• 沸点：
  279.9±23.0 °C(Predicted)
• 密度：
  1.062±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(Methylthio)hexanoic acid 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 12.33h， 生成 6-(methylthio)hexan-1-ol
  参考文献：
  名称：

  Total synthesis of the racemic alkaloid diptocarpamine

  摘要：

  DOI：

  10.1007/bf00598411
• 作为产物：
  描述：

  5-己烯酸 以100%的产率得到
  参考文献：
  名称：

  TOLSTIKOVA, O. V.;TOLSTIKOV, A. G.;SHMAKOV, V. S.;GALKIN, E. G.;VYRYPAEV,+, XIMIYA PRIROD. SOED.,(1989) N, S. 232-236

  摘要：

  DOI：

文献信息

• [EN] 4-AMINO OR 4-ALKOXY-SUBSTITUTED ARYL SULFONAMIDE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS<br/>[FR] COMPOSÉS D'ARYLE SULFONAMIDE SUBSTITUÉS PAR 4-AMINO OU 4-ALCOXY AYANT UNE ACTIVITÉ SÉLECTIVE DANS DES CANAUX SODIQUES SENSIBLES À LA TENSION
  申请人：MERCK SHARP & DOHME

  公开号：WO2020117626A1

  公开（公告）日：2020-06-11

  Disclosed are compounds of Formula (I), Formula (II), or a salt thereof: Formula (I) Formula (II) which compounds have properties for inhibiting Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula (I), Formula (II) or their salts, and methods of treating pain disorders, cough, and itch using the same.

  揭示了化合物的结构式（I）、结构式（II）或其盐：结构式（I） 结构式（II），这些化合物具有抑制在外周和交感神经元中发现的Nav 1.7离子通道的性质。还描述了包含结构式（I）、结构式（II）或其盐的药物配方，以及使用它们治疗疼痛障碍、咳嗽和瘙痒的方法。
• GOLD NANOPARTICLES AND METHODS OF MAKING AND USING GOLD NANOPARTICLES
  申请人：University of Oregon

  公开号：US20150353580A1

  公开（公告）日：2015-12-10

  Disclosed herein are embodiments of gold nanoparticles and methods of making and using the gold nanoparticles. The disclosed gold nanoparticles have core sizes and polydispersities controlled by the methods of making the gold nanoparticles. In some embodiments, the methods of making the gold nanoparticles can concern using flow reactors and reaction conditions controlled to make gold nanoparticles having a desired core size. The gold nanoparticles disclosed herein also comprise various ligands that can be used to facilitate the use of the gold nanoparticles in a variety of applications.

  本文揭示了金纳米颗粒的实施方式以及制备和使用金纳米颗粒的方法。所述的金纳米颗粒具有由制备金纳米颗粒的方法控制的核心尺寸和聚分散性。在某些实施方式中，制备金纳米颗粒的方法可能涉及使用流动反应器和控制反应条件，以制备具有所需核心尺寸的金纳米颗粒。本文揭示的金纳米颗粒还包括各种配体，可用于促进金纳米颗粒在各种应用中的使用。
• Apparatus and method for obtaining glycoglycerolipids and glycosphingolipids from lipid phases
  申请人：Nanoscience for life GmbH & CoKG

  公开号：US10239906B2

  公开（公告）日：2019-03-26

  The present invention relates to an apparatus and method for separating glycoglycerolipids and also glycoglycerolipids and glycosphingolipids from a lipid phase that contains glycoglycerolipids and acyl glycerides or glycoglycerolipids and glycosphingolipids and acyl glycerides, in mild conditions with no hydrolysis and while at the same time effectively depleting the lipid phase of said glycoglycerolipids, glycoglycerolipids and glycosphingolipids and their accompanying substances using an aqueous extraction process.

  本发明涉及一种从含有甘油三酯和酰基甘油酯或甘油三酯和酰基甘油酯的脂相中分离甘油三酯以及甘油三酯和甘磷脂的装置和方法、在不水解的温和条件下，同时使用水提取工艺有效地去除脂相中的上述甘油三酯、甘油三酯和甘磷脂及其伴随物质。
• Evaluation of Methylthio-, Methylsulfinyl-, and Methylsulfonyl-Analogs of Alkanes and Alkanoic Acids as Cardiac Inotropic and Antifungal Agents
  作者：Nadeem Iqbal、Carol-Anne McEwen、Soroush Sardari、Mohsen Daneshtalab、Edward E. Knaus

  DOI：10.1002/1521-4184(20009)333:9<293::aid-ardp293>3.0.co;2-2

  日期：2000.9

  A group of alkane and alkanoic acid compounds of general formula MeS(O)m(CH2)nR [m = 0-2; n = 1, 5, 13; R = Me, CO2H(Na)] were synthesized for evaluation as cardiac inotropic and antifungal agents. Inotropic activity was determined as the ability of the test compound to modulate in vitro guinea pig atrium contractility. The oxidation state of the S-atom was an important determinant of inotropic modulation since the thio (m = 0) analogs exhibited a positive inotropic effect. In contrast, the sulfinyl (m = 1) and sulfonyl (m = 2) analogs exhibited a negative inotropic effect. A pentyl spacer (n = 5) provided the largest positive or negative inotropic effect. The relative positive, and negative, inotropic potency orders with respect to the R-substituent were Me > or = CO2H, and CO2Na > or = Me, respectively. The most potent positive inotrope MeS(CH2)5Me (EC50 = 4.49 x 10(-6) M) could serve as a useful lead-compound for the design of a new class of positive inotropic agents. In a broad spectrum antifungal screen, the minimal inhibitory concentration (MIC) range for the five most active compounds was MeSO2(CH2)5Me (0.46-1.83 mM), MeS(CH2)13Me (0.31-1.23 mM), MeSO(CH2)13Me (< 0.009-1.87 mM), MeSO2(CH2)13Me (0.27-1.09 mM), and MeS(CH2)13CO2H (0.27-1.09 mM), relative to the reference drug Ampotericin B (< 0.0002-0.002 mM). The most active antifungal agent MeSO(CH2)13Me was selective against C. guillermondi, C. neoformans, S. cerevisiae, and A. fumigatus (strain TIMM 1776).
• Modification of the Swern Oxidation:  Use of a Soluble Polymer-Bound, Recyclable, and Odorless Sulfoxide
  作者：Joanna M. Harris、Yaoquan Liu、Shengyong Chai、Mark D. Andrews、John C. Vederas

  DOI：10.1021/jo972304i

  日期：1998.4.1