D-(-)-phenylglycyl chloride hydrochloride | 59510-99-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-(-)-phenylglycyl chloride hydrochloride
• 英文别名: (-)-phenylglycyl chloride hydrochloride；N-Phenylglycyl chloride hydrochloride；D-(-)-Phenylglycyl chloride HCl；(-) phenylglycine acid chloride hydrochloride；D-(-)-phenylaminoacetylchloride hydrochloride；D-(-)-phenylglycine chloride hydrochloride；Benzeneacetyl chloride, alpha-amino-, hydrochloride, (alphaS)-；2-anilinoacetyl chloride;hydrochloride
• CAS: 59510-99-5
• 化学式: C₈H₈ClNO*ClH
• 分子量: 206.072
• InChiKey: DVMQNHACVBLYQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.29
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  D-(-)-phenylglycyl chloride hydrochloride 、 癸醇 在 sodium 作用下， 以 正己烷 、 正庚烷 为溶剂， 生成 D(-)phenylglycine decyl ester hydrochloride
  参考文献：
  名称：

  Resolution of racemic mandelic acid

  摘要：

  将光学分辨苯甘氨酸酯或苯甘氨酸酯盐酸盐与混合的苯甘氨酸酸接触在反应介质中，并回收D(-)-苹果酸和L(+)-苹果酸形式；某些D(-)和L(+)-苯甘氨酸酯和盐酸盐被提供作为新颖的分辨剂。

  公开号：

  US04322548A1
• 作为产物：
  描述：

  N-苯基甘氨酸 在 五氯化磷 作用下， 以 异丁酰胺 、 乙腈 为溶剂， 以90%的产率得到D-(-)-phenylglycyl chloride hydrochloride
  参考文献：
  名称：

  Process for the activation of carboxylic acids

  摘要：

  一种用于激活羧酸的方法，可用于将这些羧酸转化为相应的酰胺或酯，其基于将2-噁唑烷酮与五氯化磷反应，并随后添加待激活的羧酸盐。

  公开号：

  US04230849A1

文献信息

• Process for producing carbamoyl substituted penams and carbamoyl
  申请人：Bristol-Myers Company

  公开号：US04310459A1

  公开（公告）日：1982-01-12

  Penicillin sulfoxide esters are reacted with an isocyanate to produce the corresponding (substituted)-2-carbamoyloxymethylpenam, the corresponding (substituted)-3-carbamoyloxycepham or the corresponding 3-methylcephem. The 6- or 7-side-chain of these products may be cleaved to give the corresponding 6-amino (penams) or 7-amino (cephams and cephems) compounds, and the latter may be reacylated to produce different 6-acyl-2-carbamoyloxymethyl penams, 7-acyl-3-carbamoyloxy cephams and 7-acyl-3-methylcephems. The substituent groups may be removed from the (substituted-2-carbamoyloxypenams or the (substituted)-3-carbamoyloxycephams to give the corresponding free 2-carbamoyloxymethylpenams or 3-carbamoyloxycephams, respectively.

  盼西林亚砜酯与异氰酸酯反应，生成相应的（取代）-2-氨基羧甲基青霉素，相应的（取代）-3-氨基羧甲氧头孢菌素或相应的3-甲基头孢菌素。这些产物的6-或7-侧链可以被裂解，得到相应的6-氨基（青霉素）或7-氨基（头孢菌素和头孢菌素）化合物，后者可以重新酰化，产生不同的6-酰基-2-氨基羧甲基青霉素，7-酰基-3-氨基羧甲氧头孢菌素和7-酰基-3-甲基头孢菌素。这些取代基团可以从（取代）-2-氨基羧甲氧青霉素或（取代）-3-氨基羧甲氧头孢菌素中去除，分别得到相应的游离2-氨基羧甲基青霉素或3-氨基羧甲氧头孢菌素。
• Use of long-chain alcohol derivatives for the treatment of alopecia areata
  申请人：Hayardeny-Nisimov Liat

  公开号：US20080221115A1

  公开（公告）日：2008-09-11

  Disclosed is a method of treating alopecia greata using a compound having the formula: wherein R 1 is C 10 -C 24 alkenyl; R 2 is H, C 1 -C 6 alkyl, aryl, or aralkyl, where any aryl moiety may be unsubstituted or substituted by nitro, cyano, halo, hydroxyl, NR 6 R 7 , or CR 8 R 8 NR 6 R 7 , where R 6 , R 7 , and R 8 each independently is H or C 1 -C 6 alkyl; and R 3 and R 4 each independently is H or C 1 -C 6 alkyl, or R 3 and R 4 together with the nitrogen atom to which they are attached form a 5-7 membered heterocyclic saturated ring optionally containing an additional N or O, which is unsubstituted or substituted by C 1 -C 6 alkyl, or an enantiomer or a pharmaceutically acceptable salt of the compound.

  本公开涉及一种治疗秃头的方法，使用具有下式的化合物： 其中R1为C10-C24烯基；R2为H、C1-C6烷基、芳基或芳基烷基，其中任何芳基基团可以未取代或取代为硝基、氰基、卤素、羟基、NR6R7或CR8R8NR6R7，其中R6、R7和R8各自独立地为H或C1-C6烷基；而R3和R4各自独立地为H或C1-C6烷基，或者R3和R4与它们连接的氮原子一起形成一个5-7成员杂环饱和环，该环可以选择性地包含一个额外的N或O，该N或O未取代或取代为C1-C6烷基，或者是该化合物的对映体或药用可接受的盐。
• Enantiomers of amino-phenyl-acetic acid octadec-9-(z) enyl ester, their salts and their uses
  申请人：Herzig Yaacov

  公开号：US20080221209A1

  公开（公告）日：2008-09-11

  Disclosed are enantiomers of amino-phenyl-acetic acid octadec-9-(Z)-enyl ester, and salts thereof, including pharmaceutical compositions, uses and a process for the manufacture thereof.

  本文披露了氨基苯乙酸辛烯-9-(Z)-基酯的对映体及其盐，包括药物组合物、用途和制造过程。
• 7-[D-(.alpha.-amino-.alpha.-phenyl-, 2-thienyl- and
  申请人：Bristol-Myers Company

  公开号：US03985740A1

  公开（公告）日：1976-10-12

  7-[D-(.alpha.-Amino-.alpha.-phenyl-, 2-thienyl- and 3-thienylacetamido)]-3-(thiazol-2-yl)carbonylthiomethyl-3-cephem-4-carboxy lic acid and 7-[D-(.alpha.-amino-.alpha.-phenyl-, 2-thienyl- and 3-thienylacetamido)]-3-(5-methylthiazol-2-yl)carbonylthiomethyl-3-cephem-4 -carboxylic acid and their pharmaceutically acceptable salts are valuable as antibacterial agents, as nutritional supplements in animal feeds, as agents for the treatment of mastitis in cattle and as therapeutic agents in poultry and animals, including man. The compounds are especially useful in the treatment, particularly by oral administration, of infectious diseases caused by many Gram-positive and Gram-negative bacteria. Also included within the invention are easily cleavable esters of the above acids and pharmaceutically acceptable acid addition salts of said esters.

  7-[D-(.alpha.-氨基-.alpha.-苯基-, 2-噻吩基和3-噻吩基乙酰基)]-3-(噻唑-2-基)羰基硫甲基-3-头孢烯-4-羧酸和7-[D-(.alpha.-氨基-.alpha.-苯基-, 2-噻吩基和3-噻吩基乙酰基)]-3-(5-甲基噻唑-2-基)羰基硫甲基-3-头孢烯-4-羧酸及其药用可接受的盐在抗菌剂方面具有价值，在动物饲料中作为营养补充剂，在牛群乳腺炎治疗剂和家禽动物治疗剂方面具有价值，包括人类。这些化合物在治疗由许多革兰氏阳性和革兰氏阴性细菌引起的传染病方面特别有用，尤其是通过口服给药。发明还包括上述酸的易于水解的酯以及该酯的药用可接受的酸盐。
• Cephem Derivatives and a process for their manufacture
  申请人：KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

  公开号：EP0301257A2

  公开（公告）日：1989-02-01

  Cephem derivatives of the formula and physiologically acceptable salts thereof, a process for their manufacture, pharmaceutical preparations containing them and the intermediates of the formula

  Cephem衍生物的公式及其生理上可接受的盐，其制备方法，含有它们的药物制剂以及该公式的中间体。