trimellitic acid amide-imide | 21343-93-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: trimellitic acid amide-imide
• 英文别名: 1,3-dioxo-1,3-dihydro-isoindole-5-carboxylic acid amide；4-carbamoylphthalimide；1,3-dioxoisoindole-5-carboxamide
• CAS: 21343-93-1
• 化学式: C₉H₆N₂O₃
• 分子量: 190.158
• InChiKey: HWUDVZCMZSHYQZ-UHFFFAOYSA-N

物化性质

• 熔点：
  312 °C
• 密度：
  1.506±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  89.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  trimellitic acid amide-imide 在 N-甲基吡咯烷酮 、 氯化亚砜 、 一水合肼 、 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 为溶剂， 反应 6.5h， 生成 1-chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanophthalazine
  参考文献：
  名称：

  4-Benzylamino-1-chloro-6-substituted Phthalazines:  Synthesis and Inhibitory Activity toward Phosphodiesterase 5

  摘要：

  We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted phthalazines (16) and evaluated their inhibitory activity toward phosphodiesterase 5 (PDE5) purified from porcine platelets. The PDE5-inhibitory activities of 15 were greater than those of the isomers (16). The preferred substituent at the 4-position of phthalazine was a (3-chloro-4-methoxybenzyl)amino group, and those at the B-position were cyano, nitro, and trifluoromethyl groups. Compounds 15a (IC50 = 4.8 nM), 15f (3.5 nM), and 15i (5.3 nM) were more potent inhibitors than E4021 (8.6 nM). Compounds 15a and 15f also showed vasorelaxant activity in isolated porcine coronary arteries precontracted with prostaglandin F-2 alpha (10(-5) M). The EC50 values for vasorelaxant action of 15a, 15f, and E4021 were 150, 160, and 980 nM, respectively. These results show that novel PDE5 inhibitors possessing a potent vasorelaxant effect may exist among phthalazine derivatives.

  DOI：

  10.1021/jm970815r
• 作为产物：
  描述：

  1,2,4-苯三甲酸 在 尿素 作用下， 反应 2.0h， 以80%的产率得到trimellitic acid amide-imide
  参考文献：
  名称：

  硅胶固定化铝酞菁配合物作为合成α-氨基膦酸盐的多相催化剂

  摘要：

  固定在硅胶上的铝酞菁配合物（CPG-550 是可控孔玻璃，MCM-41 是介孔分子筛）在 Kabachnik-Fields 反应中表现出很高的催化活性和稳定性。

  DOI：

  10.1007/s11172-011-0040-z

文献信息

• Fused pyridazine compounds
  申请人：Eisai Co., Ltd.

  公开号：US05849741A1

  公开（公告）日：1998-12-15

  A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma. ##STR1##

  以下是一种融合吡啶并嘧啶化合物，其化学式如下（I），或其药理学上可接受的盐，具有对环磷酸鸟苷磷酸二酯酶（以下简称“cGMP-PDE”）的抑制活性。这些化合物可用作预防和治疗剂，用于对于cGMP-PDE抑制活性有效的疾病，例如缺血性心脏病，如心绞痛，心肌梗死和慢性和急性心衰，肺动脉高压，动脉硬化和支气管哮喘。##STR1##
• Amide-imide copolymer resin of lowered water absorption and composites made therefrom
  申请人：AMOCO CORPORATION

  公开号：EP0417897A1

  公开（公告）日：1991-03-20

  Polyamide-imide matrix resins derived from trimellitic acid compounds and an aromatic diamine are improved in moisture resistance when from 10 to about 90 mole % of the trimellitic acid compounds are replaced by biphenyl tetracarboxylic acid compounds. The matrix resins are particularly useful for fiber-filled composites having improved retention of properties when exposed to moisture.

  当 10 至约 90 摩尔％的偏苯三酸化合物被联苯四羧酸化合物取代时，由偏苯三酸化 合物和芳香族二胺衍生的聚酰胺-酰亚胺基体树脂的防潮性能得到改善。这种基体树脂特别适用于纤维填充复合材料，在受潮时能更好地保持其特性。
• Imide- and amide-imide containing copolymer
  申请人：AMOCO CORPORATION

  公开号：EP0492948A1

  公开（公告）日：1992-07-01

  Improved imide-containing copolymers comprising, in the aromatic diamine component, p-phenylene diamine and at least one additional aromatic diamine have increased rigidity and useful processability. The copolymers of this invention also may exhibit improved resistance to the detrimental effects of humid environments and retain mechanical properties at elevated temperatures after exposure to humid environments

  在芳香族二胺组分中包含对苯二胺和至少另外一种芳香族二胺的改进型含亚胺共聚物具有更高的刚性和有用的加工性。本发明的共聚物还能更好地抵抗潮湿环境的有害影响，并在暴露于潮湿环境后在高温下保持机械性能。
• FUSED PYRIDAZINE COMPOUND
  申请人：Eisai Co., Ltd.

  公开号：EP0722936A1

  公开（公告）日：1996-07-24

  A fused pyridazine compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof which exhibits an inhibitory activity against cyclic GMP phosphodiesterase (hereinafter referred to as "cGMP-PDE"). The compounds are useful as preventive and therapeutic agents for diseases for which a cGMP-PDE inhibiting action is efficacious, for example, ischemic heart diseases such as angina pectoris, myocardial infarct and chronic and acute cardiac failure, pulmonary hypertension, arteriosclerosis and bronchial asthma.

  由以下通式（I）代表的融合哒嗪化合物或其药理学上可接受的盐，对环 GMP 磷酸二酯酶（以下简称 "cGMP-PDE"）具有抑制活性。 这些化合物可作为 cGMP-PDE 抑制作用有效的疾病的预防和治疗药物，例如缺血性心脏病，如心绞痛、心肌梗塞、慢性和急性心力衰竭、肺动脉高压、动脉硬化和支气管哮喘。
• Production method of beta-type copper phthalocyanine pigment
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0783029A1

  公开（公告）日：1997-07-09

  A production method of beta-type copper phthalocyanine pigment comprising steps of: a) producing a reaction mixture containing crude copper phthalocyanine in an organic solvent; b) wet-grounding the reaction mixture by mechanical energy to form a suspension; c) removing the organic solvent from the obtained suspension does not contaminate the work environment and represents an improvement in terms of both productivity and economic savings compared with conventional methods. The beta-type copper phthalocyanine pigment produced by this method demonstrates excellent dispersability, such that it may be dispersed without further modification in a resin, varnish, plastic or other medium as required, to produce a paint, ink, or plastic tinting agent, for example.

  一种生产β型铜酞菁颜料的方法，包括以下步骤：a) 在有机溶剂中生成含有粗铜酞菁的反应混合物；b) 利用机械能对反应混合物进行湿法研磨，形成悬浮液；c) 从获得的悬浮液中去除有机溶剂，这种方法不会污染工作环境，与传统方法相比，在生产效率和经济效益方面都有所提高。用这种方法制得的β型铜酞菁颜料具有极佳的分散性，可根据需要分散在树脂、清漆、塑料或其他介质中，而无需进一步改性，例如可用于生产油漆、墨水或塑料着色剂。