6-bromo-2,2,8-tritert-butyl-4H-1,3,2-benzodioxasiline | 1095170-89-0

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 6-bromo-2,2,8-tritert-butyl-4H-1,3,2-benzodioxasiline
• CAS: 1095170-89-0
• 化学式: C₁₉H₃₁BrO₂Si
• 分子量: 399.443
• InChiKey: NNHSJNRWMMIAPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-二甲基乙酰胺 、 6-bromo-2,2,8-tritert-butyl-4H-1,3,2-benzodioxasiline 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以63%的产率得到1-(2,2,8-tritert-butyl-4H-1,3,2-benzodioxasilin-6-yl)ethanone
  参考文献：
  名称：

  5-(1-Acetoxyvinyl)-cycloSaligenyl-2′,3′-dideoxy-2′,3′- didehydrothymidine Monophosphates, a Second Type of New, Enzymatically Activated cycloSaligenyl Pronucleotides

  摘要：

  In our attempt to further develop the cycloSal pronucleotide concept, we report oil 5-(1-acetoxyvinyl)-cycloSal-d4TMPs as a new type of enzyme-activated pronucleotides. These compounds were converted into 5-acetyl-cycloSal-d4TMPs by (carboxy)esterase cleavage inside the cells. The enzymatic reaction led to the formation of a strong electron-withdrawing substituent that strongly accelerates the chemical hydrolysis of the cycloSal nucleotide to give d4TMP. For some cycloSal-d4TMPs a separation into the diastereomers was achieved. The absolute configuration was assigned by correlation of circular dichroism spectra with similar compounds. Most of the compounds showed complete retention of antiviral activity in TK-deficient CEM/TK- cells, which proves the TK-bypass potential of this approach. Interestingly, (S-p)-isomers of cycloSal phosphate triesters showed better antiviral activity in HIV-2-infected thymidine-kinase deficient CEM/TK- cells than their (R-p)-counterparts.

  DOI：

  10.1021/jm801197f
• 作为产物：
  描述：

  4-bromo-6-tert-butylsalicyl alcohol 、 二叔丁基硅基双(三氟甲烷磺酸) 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以90%的产率得到6-bromo-2,2,8-tritert-butyl-4H-1,3,2-benzodioxasiline
  参考文献：
  名称：

  5-(1-Acetoxyvinyl)-cycloSaligenyl-2′,3′-dideoxy-2′,3′- didehydrothymidine Monophosphates, a Second Type of New, Enzymatically Activated cycloSaligenyl Pronucleotides

  摘要：

  In our attempt to further develop the cycloSal pronucleotide concept, we report oil 5-(1-acetoxyvinyl)-cycloSal-d4TMPs as a new type of enzyme-activated pronucleotides. These compounds were converted into 5-acetyl-cycloSal-d4TMPs by (carboxy)esterase cleavage inside the cells. The enzymatic reaction led to the formation of a strong electron-withdrawing substituent that strongly accelerates the chemical hydrolysis of the cycloSal nucleotide to give d4TMP. For some cycloSal-d4TMPs a separation into the diastereomers was achieved. The absolute configuration was assigned by correlation of circular dichroism spectra with similar compounds. Most of the compounds showed complete retention of antiviral activity in TK-deficient CEM/TK- cells, which proves the TK-bypass potential of this approach. Interestingly, (S-p)-isomers of cycloSal phosphate triesters showed better antiviral activity in HIV-2-infected thymidine-kinase deficient CEM/TK- cells than their (R-p)-counterparts.

  DOI：

  10.1021/jm801197f

文献信息

• 5-(1-Acetoxyvinyl)-<i>cyclo</i>Saligenyl-2′,3′-dideoxy-2′,3′- didehydrothymidine Monophosphates, a Second Type of New, Enzymatically Activated <i>cyclo</i>Saligenyl Pronucleotides
  作者：Nicolas Gisch、Florian Pertenbreiter、Jan Balzarini、Chris Meier

  DOI：10.1021/jm801197f

  日期：2008.12.25

  In our attempt to further develop the cycloSal pronucleotide concept, we report oil 5-(1-acetoxyvinyl)-cycloSal-d4TMPs as a new type of enzyme-activated pronucleotides. These compounds were converted into 5-acetyl-cycloSal-d4TMPs by (carboxy)esterase cleavage inside the cells. The enzymatic reaction led to the formation of a strong electron-withdrawing substituent that strongly accelerates the chemical hydrolysis of the cycloSal nucleotide to give d4TMP. For some cycloSal-d4TMPs a separation into the diastereomers was achieved. The absolute configuration was assigned by correlation of circular dichroism spectra with similar compounds. Most of the compounds showed complete retention of antiviral activity in TK-deficient CEM/TK- cells, which proves the TK-bypass potential of this approach. Interestingly, (S-p)-isomers of cycloSal phosphate triesters showed better antiviral activity in HIV-2-infected thymidine-kinase deficient CEM/TK- cells than their (R-p)-counterparts.