N-benzenesulfonyl-bis(2-hydroxyethyl)amine | 13127-79-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzenesulfonyl-bis(2-hydroxyethyl)amine
• 英文别名: N,N-bis-(2-hydroxy-ethyl)-benzenesulfonamide；N,N-Bis-(2-hydroxy-aethyl)-benzolsulfonamid；N,N-[bis(2-hydroxyethyl)]phenyl sulfonamide；N,N-[bis(2-hydroxyethyl)]phenylsulfonamide；N,N-bis(2-hydroxyethyl)benzenesulfonamide
• CAS: 13127-79-2
• 化学式: C₁₀H₁₅NO₄S
• 分子量: 245.299
• InChiKey: DQHSFCBOCSEJGK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  86.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-benzenesulfonyl-bis(2-hydroxyethyl)amine 生成 4-(苯基磺酰基)吗啉
  参考文献：
  名称：

  Smirnowa et al., Meditsinskaya Promyshlennost SSSR, 1958, vol. 12, # 7, p. 31,34

  摘要：

  DOI：
• 作为产物：
  描述：

  二乙醇胺 、 苯磺酰氯 在 吡啶 作用下， 反应 3.5h， 以74.3%的产率得到N-benzenesulfonyl-bis(2-hydroxyethyl)amine
  参考文献：
  名称：

  Synthesis and Crystal Structure of N,N-Bis[(4-aminophenoxy)ethyl]benzene Sulfonamide

  摘要：

  二乙醇胺与苯磺酰氯反应生成苯磺酸中间体，然后被 4-硝基苯酚亲核取代，随后在活性炭和氯化铁（III）存在下被水合肼还原。制备出了一种新的二元芳香胺 N,N-双[(4-氨基苯氧基)乙基]苯磺酰胺。通过红外光谱、1H NMR 和单晶 X 射线衍射分析，对中间产物和最终产品进行了结构表征。

  DOI：

  10.14233/ajchem.2014.15827

文献信息

• PROCESS FOR PREPARATION OF SUBSTANTIALLY OPTICALLY PURE LEVOROTATORY AND DEXTROROTATORY ENANTIOMERS OF CETIRIZINE USING NOVEL INTERMEDIATES
  申请人：Mohan Rao Dodda

  公开号：US20090281318A1

  公开（公告）日：2009-11-12

  The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.

  本发明涉及一种新颖且商业可行的过程，用于生产左旋和右旋异构体的赛曲唑中间体1-[(4-氯苯基)苯甲基]哌嗪，从而高纯度高产率地生产赛曲唑的左旋和右旋异构体及其药用可接受的酸盐。
• Plasticized polymer compositions
  申请人：UCB, S.A.

  公开号：US20020165301A1

  公开（公告）日：2002-11-07

  The invention relates to compositions comprising at least one polymer and at least one plasticizer, in which compositions the polymer is semi-crystalline and exhibits a processing temperature equal to or greater than 220° C., preferably 250° C., and the plasticizer is an aromatic benzenesulphonamide represented by the general formula (I) 1 in which R 1 represents a hydrogen atom, a C 1 -C 4 alkyl group or a C 1 -C 4 alkoxy group, X represents a linear or branched C 2 -C 10 alkylene group, or a cycloaliphatic group, or an aromatic group, Y represents one of the groups OH or 2 R 2 representing a C 1 -C 4 alkyl group or an aromatic group, these groups optionally themselves being substituted by an OH or C 1 -C 4 alkyl group. The aromatic benzenesulphonamides have little volatility and exhibit good thermal stability, which makes it possible to effectively plasticize polyamides which are processed at high temperatures, such as polyamides-6, -6,6, -4,6, -6,9, -6,10, -6,12 and MDX-6 and polyketones, but also polyamides-11 and -12, polyoxymethylene and poly(vinylidene fluoride).

  本发明涉及一种包含至少一种聚合物和至少一种增塑剂的组合物，其中聚合物是半结晶的，处理温度等于或大于220℃，优选为250℃，增塑剂是一种芳香基苯磺酰胺，其通式为（I）： 其中，R1代表氢原子、C1-C4烷基或C1-C4烷氧基；X代表线性或支链状的C2-C10烷基、环状脂肪族基、芳香族基；Y代表OH基或2个R2代表C1-C4烷基或芳香族基，这些基团可以自身被OH基或C1-C4烷基所取代。 这些芳香基苯磺酰胺的挥发性很小，具有良好的热稳定性，可以有效地增塑高温加工的聚酰胺，如聚酰胺-6、-6,6、-4,6、-6,9、-6,10、-6,12和MDX-6以及聚酮，还可以增塑聚酰胺-11和-12、聚甲醛和聚偏氟乙烯。
• Particles for electrophoretic displays
  申请人：Merck Patent GmbH

  公开号：US10344167B2

  公开（公告）日：2019-07-09

  This invention relates to polymer particles, a process for their preparation, the use of these particles for the preparation of an electrophoretic device, electrophoretic displays comprising such particle, and new polymerizable dyes.

  本发明涉及聚合物颗粒、其制备工艺、使用这些颗粒制备电泳装置、包含这种颗粒的电泳显示器以及新型可聚合染料。
• Bis-azo colorants for use as bluing agents
  申请人：Miracle Gregory Scot

  公开号：US10876079B2

  公开（公告）日：2020-12-29

  Bis-azo colorants for use as bluing agents, laundry care compositions including bis-azo colorants that may serve as bluing agents, processes for making such bluing agents and laundry care compositions and methods of using the same. The bluing agents are generally include at least two components: at least one chromophore component and at least one polymeric component. These bluing agents are advantageous in providing a whitening effect to fabrics, while not building up over time and causing undesirable blue discoloration to the treated fabrics.

  用作发蓝剂的双偶氮着色剂、包括可用作发蓝剂的双偶氮着色剂的衣物护理组合物、制造此类发蓝剂和衣物护理组合物的工艺以及使用方法。发蓝剂一般至少包括两种成分：至少一种发色团成分和至少一种聚合物成分。这些发蓝剂在为织物提供增白效果方面具有优势，同时不会随着时间的推移而积聚，导致处理过的织物出现不希望看到的蓝色褪色。
• DE695216
  申请人：——

  公开号：——

  公开（公告）日：——