rosanilin | 632-99-5

• 物质功能分类: 染料及颜料 - 染料 - 碱性染料
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: rosanilin
• 英文别名: 4-[(4-aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl]-2-methylaniline hydrochloride；Rosaniline chloride；2-methyl-4,4’-[(4-imino-2,5-cyclohexadien-1-ylidene)methylene]dianiline hydrochloride；4-[(4-aminophenyl)-(4-imino-1-cyclohexa-2,5-dienylidene)methyl]aniline hydrochloride；rosaniline hydrochloride；basic fuchsine；Basic fuchsin
• CAS: 632-99-5
• 化学式: C₂₀H₂₀N₃*Cl
• 分子量: 337.852
• InChiKey: NIKFYOSELWJIOF-SVFFXJIWSA-N

物化性质

• 熔点：
  250 °C
• 沸点：
  300℃[at 101 325 Pa]
• 密度：
  0.999 g/mL at 20 °C
• 闪点：
  48 °F
• 溶解度：
  水中的溶解度为1mg/mL
• 最大波长(λmax)：
  543 nm
• LogP：
  1.632 at 25℃
• 稳定性/保质期：
  <b>远离氧化物。</b>

计算性质

• 辛醇/水分配系数(LogP)：
  4.53
• 重原子数：
  24.0
• 可旋转键数：
  2.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  75.89
• 氢给体数：
  3.0
• 氢受体数：
  3.0

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xn
• 安全说明：
  S16,S36/37,S7
• 危险类别码：
  R22,R40
• WGK Germany：
  3
• 海关编码：
  3204130000
• 危险品运输编号：
  UN 2924 3/PG 2
• RTECS号：
  CX9850000
• 包装等级：
  III
• 危险类别：
  9
• 危险性防范说明：
  P201,P202,P264,P273,P280,P302+P352,P305+P351+P338,P308+P313,P332+P313,P337+P313,P391,P405,P501
• 危险性描述：
  H315,H319,H350,H410
• 储存条件：
  应将物品存放在密封容器中，并置于阴凉、干燥处。存储位置需远离氧化剂。

SDS

Name:	Pararosaniline (Fuchsin Basic) Material Safety Data Sheet
Synonym:	Basic Violet 14, Hydrochloride; C.I. 42510; Rosaniline Chloride; Magenta
CAS:	632-99-5

Section 1 - Chemical Product MSDS Name:Pararosaniline (Fuchsin Basic) Material Safety Data Sheet
Synonym:Basic Violet 14, Hydrochloride; C.I. 42510; Rosaniline Chloride; Magenta

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
632-99-5	Pararosaniline (Fuchsin Basic)	ca 100	211-189-6

Hazard Symbols: XN
Risk Phrases: 33

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Danger of cumulative effects.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation. May be absorbed through the skin in harmful amounts. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. If absorbed, causes symptoms similar to those of ingestion.
Ingestion:
May cause irritation of the digestive tract. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, and death.
Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood. Exposure may cause anemia and other blood abnormalities.
Inhalation:
May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), convulsions, tachycardia, dyspnea (labored breathing), and death. May cause effects similar to those described for ingestion. Methemoglobinemia is characterized by dizziness, drowsiness, headache, shortness of breath, cyanosis (bluish discoloration of skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown blood.
Chronic:
Prolonged or repeated skin contact may cause dermatitis. Chronic inhalation and ingestion may cause effects similar to those of acute inhalation and ingestion. Prolonged exposure may cause anemia and methemoglobinemia, characterized by dizziness, drowsiness, headache, breath shortness, cyanosis (bluish skin due to deficient oxygenation of the blood), rapid heart rate and chocolate-brown colored blood.
Chronic exposure can affect thyroid function. May cause pituitary gland abnormalities.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
For methemoglobinemia, administer oxygen alone or with Methylene Blue depending on the methemoglobin concentration in the blood.
Antidote: Methylene blue, alone or in combination with oxygen is indicated as a treatment in nitrite induced methemoglobinemia.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. This material in sufficient quantity and reduced particle size is capable of creating a dust explosion.
Extinguishing Media:
Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing.
Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 632-99-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: dark green
Odor: Odorless
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 250 deg C dec
Autoignition Temperature: Not applicable.
Flash Point: 200 deg C ( 392.00 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: 200 deg C
Solubility in water: 0.26%
Specific Gravity/Density:
Molecular Formula: C20H20ClN3
Molecular Weight: 337.84

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable. However, may decompose if heated.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat.
Incompatibilities with Other Materials:
Aniline is incompatible with acetic anhydride, chlorosulfonic acid, hexachloromelamine, nitric acid , nitric acid + nitrogen tetroxide and sulfuric acid, nitrobenzene and glycerine, oleum, ozone, perchloric acid + formaldehyde, perchromates, performic acid, potassium peroxide, propiolactone(beta), silver perchlorate, sodium peroxide, sulfuric acid, trichloromelamine, oxidizing materials, acids, anilinium chloride, benzenediazonium-2-carboxylate, boron trichloride, 1-chloro-2,3-epoxypropane, dibenzoyl peroxide, nitromethane, nitrous acid, and tetranitromethane.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Will not occur.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 632-99-5: CX9850000 LD50/LC50:
Not available.
Carcinogenicity:
Pararosaniline (Fuchsin Basic) - IARC: Group 2B carcinogen Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.

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Section 14 - TRANSPORT INFORMATION

IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XN
Risk Phrases:
R 33 Danger of cumulative effects.
Safety Phrases:
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 632-99-5: No information available.
Canada
CAS# 632-99-5 is listed on Canada's DSL List.
CAS# 632-99-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 632-99-5 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

人工染料，即苯胺染料或煤焦油染料，种类繁多，应用广泛。其缺点是经日光照射容易褪色，特别是苯胺蓝、亮绿和甲基绿等更为明显。在制片中要注意控制酸碱度，并避免日光直射，以确保颜色能保持几年不褪。

化学性质 黄绿色闪光结晶块状或砂状物。溶于冷水和热水呈红紫色，极易溶于酒精中呈红色。遇浓硫酸变黄棕色，稀释后几乎无色。其水溶液加入氢氧化钠液后，会呈现带有红色沉淀的几乎无色液体。

用途

1. 用于配制席夫试剂检测醛类，并用于萃取光度法测定某些酸根离子及金属离子。
2. 用于光度法检测溴、亚硝酸盐和二氧化硫。
3. 用作极谱分析中的极大抑制剂。
4. 染色棉、腈纶、蚕丝、皮革等，染腈纶效果较好。也可用于纸张、羽毛、麦秆、竹、木的着色，还可制造色淀。
5. 作为生化分析的核染料，是最强的核染料，能对粘朊、弹性组织及嗜品红颗粒进行染色，并可用于中枢神经的核染色和细菌学中鉴别结核杆菌。在分析化学中配制席夫试剂检验醛类，以及溴酸盐滴定的氧化还原指示剂。

生产方法 将苯胺、对甲苯胺和邻甲苯胺与硝基苯、氯化亚铁一起熔融，进行氧化缩合，然后用硫酸溶解提取，再经中和、盐析、过滤及干燥得到成品。原料消耗量如下：对甲苯胺 635 kg、盐酸（31%）210 kg、邻甲苯胺 1170 kg、硫酸 1900 kg、苯胺 470 kg、氯化锌（98%）785 kg、硝基苯 1000 kg、氢氧化钠（100%）970 kg、对硝基甲苯 360 kg、碳酸钙 330 kg、氯化亚铁（98%）800 kg。

类别 有毒物质

可燃性危险特性 可燃；火场分解产生有毒氮氧化物和氯化物烟雾

储运特性 库房低温、通风、干燥

灭火剂 水、二氧化碳、干粉、砂土

反应信息

• 作为反应物：
  描述：

  rosanilin 在 sodium hydroxide 作用下， 生成 (4-氨基-3-甲苯基)-双(4-氨苯基)甲醇
  参考文献：
  名称：

  Iyun; Peters; Babutunde, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2002, vol. 41, # 5, p. 967 - 969

  摘要：

  DOI：

文献信息

• Reagents and methods for direct labeling of nucleotides
  申请人：Naleway John J.

  公开号：US20130150254A1

  公开（公告）日：2013-06-13

  The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

  本发明提供了用于生产可激活重氮衍生物以用于标记核苷酸的系统和方法。通过将可检测基团的稳定的肼酰肼衍生物与用于直接标记核苷酸样品的活化聚合物试剂接触来完成核苷酸的标记。标记发生在核苷酸的磷酸骨架上，不会干扰标记核苷酸与其反义链的杂交。由于该方法涉及直接标记，所有类型的核苷酸都可以在不经过扩增或改变的情况下进行标记。
• [EN] AMPHIPHILIC AND MESOGENIC ORGANIC DYES FOR TAILOR-MADE REFLECTIVE LOW-DIMENSIONAL MATERIALS<br/>[FR] COLORANTS ORGANIQUES AMPHIPHILES ET MÉSOGÈNES POUR MATÉRIAUX TRIDIMENSIONNELS RÉFLÉCHISSANTS FABRIQUÉS SUR MESURE
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2020008052A1

  公开（公告）日：2020-01-09

  The present invention relates to a compound of the following formula (I): (I). The invention also relates to uses thereof as dye or pigment, notably as a luster pigment. The invention relates also to a reflective or photonic or nanophotonic or optoelectronic device comprising a compound of the invention. The invention relates also to a metal-like reflective coating,a metal-like particle or an organic-based metal-like liquid film comprising a compound of the invention.

  本发明涉及以下式（I）的化合物：（I）。该发明还涉及其作为染料或颜料的用途，特别是作为光泽颜料。该发明还涉及包括本发明化合物的反射性、光子学、纳米光子学或光电子器件。该发明还涉及包括本发明化合物的类金属反射涂层、类金属颗粒或有机基类金属液膜。
• BIOPASSIVATING MEMBRANE STABILIZATION BY MEANS OF NITROCARBOXYLIC ACID-CONTAINING PHOSPHOLIPIDS IN PREPARATIONS AND COATINGS
  申请人：Dietz Ulrich

  公开号：US20140099354A1

  公开（公告）日：2014-04-10

  The present invention relates to nitro-carboxylic acid (s)-containing phospholipids, to be used for coating of medical devices such as stents, catheter balloons, wound pads or surgical suture material and for bio-passivating compositions, such as rinses, waterproofing solutions, coating solutions, cryoprotection solutions, cold preservation media, lyoprotection solutions, contrast media solutions, preservation and reperfusion solutions containing these compounds as well as preparing solutions thereof and coating medical devices as well as their uses.

  本发明涉及一种含硝基羧酸（s）的磷脂，用于涂覆医疗器械，如支架、导管球囊、伤口垫或外科缝合材料，以及用于生物钝化组合物，如漱口液、防水溶液、涂层溶液、冷冻保护溶液、冷藏介质、冻干保护溶液、造影介质溶液、含有这些化合物的保存和再灌注溶液，以及制备这些溶液和涂覆医疗器械以及它们的用途。
• [EN] PROBES FOR RAPID AND SPECIFIC DETECTION OF MYCOBACTERIA<br/>[FR] SONDES POUR LA DÉTECTION RAPIDE ET SPÉCIFIQUE DE MYCOBACTÉRIES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2017027062A1

  公开（公告）日：2017-02-16

  The compositions of the present disclosure provide novel fluorogenic probes for use in the specific imaging and detection of mycobacteria species, and in particular β-lactam- antibiotic resistant. Specificity for mycobacteria is conferred on these probes by incorporating a moiety that specifically targets the unique trapping mechanism of the DprE1 found in in mycobacteria. Accordingly, only Mycobacteria species that express both a β- lactamase and DprE1 enable both the activation of the caged fluorescent probe, and the affixing of the released fluorescent probes to the bacteria cells through the functioning reduction-covalent binding mechanism. Advantageously, such a probe is able, at its most sensitive, to allow single mycobacterium detection.

  本公开的组成提供了新颖的生色团探针，用于特定地成像和检测分枝杆菌种类，尤其是对β-内酰胺类抗生素具有抗药性的种类。这些探针通过引入一种特定针对分枝杆菌中DprE1独特捕获机制的基团，从而实现对分枝杆菌的特异性。因此，只有表达β-内酰胺酶和DprE1的分枝杆菌种类才能激活笼状荧光探针，并通过功能性还原-共价结合机制将释放的荧光探针固定到细菌细胞上。这种探针的一个显著优点是，在其最敏感的情况下，能够实现单个分枝杆菌的检测。
• Use of polymers based on n-vinyl caprolactam in hair cosmetics
  申请人：Müller Gabi

  公开号：US20070081964A1

  公开（公告）日：2007-04-12

  Use of polymers of 30-65% by weight of N-vinylcaprolactam, 35-65% by weight of a monomer mixture of N-vinylimidazole and vinylpyrrolidone, where the weight ratio of N-vinylimidazole to vinylpyrrolidone is between 0.085 and 0.30, 0-15% by weight of a nitrogen-containing quaternizable monomer (A), which is different from N-vinylimidazole, where the sum of monomer (A) and N-vinylimidazole is less than 18% by weight, in cosmetic preparations.

  使用30-65%重量的N-乙烯基己内酰胺聚合物，35-65%重量的N-乙烯基咪唑和乙烯基吡咯烷酮的共聚物，其中N-乙烯基咪唑与乙烯基吡咯烷酮的重量比在0.085与0.30之间，0-15%重量的含氮可季铵化单体（A），该单体与N-乙烯基咪唑不同，其中单体（A）与N-乙烯基咪唑的总和少于18%的重量，用于化妆品制剂中。