N-stearoyl-L-isoleucine | 92072-20-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-stearoyl-L-isoleucine
• 英文别名: (2S,3S)-3-methyl-2-(octadecanoylamino)pentanoic acid
• CAS: 92072-20-3
• 化学式: C₂₄H₄₇NO₃
• 分子量: 397.642
• InChiKey: UQWJBYKWVVOSQB-GMAHTHKFSA-N

物化性质

• 沸点：
  550.6±33.0 °C(Predicted)
• 密度：
  0.933±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  28
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  硬脂酸 在 magnesium sulfate 、 对甲苯磺酸 、 三乙胺 作用下， 以 1,4-二氧六环 、 水 、 xylene 为溶剂， 反应 11.0h， 生成 N-stearoyl-L-isoleucine
  参考文献：
  名称：

  Higher N-acyl-L-amino acid derivatives

  摘要：

  A preparative method is proposed for obtaining higher N-acylamino acids by reaction of free amino acids with fatty acid nitrophenyl esters. It was shown that these acids can transport positive ions through a liquid lipophilic medium. A direct method is proposed for obtaining fatty acid 4-nitrophenyl esters by boiling 4-nitrophenol and the fatty acid in xylene in a Soxhlet apparatus in the presence of an acid catalyst.

  DOI：

  10.1007/bf00958844

文献信息

• AN ENZYME-CATALYZED PROCESS FOR PREPARING N-ACYL AMINO ACIDS AND N-ACYL AMINO ACID AMIDES
  申请人：NOVO NORDISK A/S

  公开号：EP0473700A1

  公开（公告）日：1992-03-11
• EP2908845A1
  申请人：——

  公开号：EP2908845A1

  公开（公告）日：2015-08-26
• Utilisation d'ester d'isosorbide et de dérivés N-acylés d'acides aminés comme agent antivieillissement de la peau humaine
  申请人：Société d'Exploitation de Produits pour les Industries Chimiques SEPPIC

  公开号：EP3209277A1

  公开（公告）日：2017-08-30
• Fatty Acid Acylated Amino Acids for Growth Hormone Delivery
  申请人：Novo Nordisk Health Care AG

  公开号：US20150250882A1

  公开（公告）日：2015-09-10

  The present invention relates to growth hormone compositions comprising a fatty acid acylated amino acids (FA-aa's), which may be used in pharmaceutical compositions such as pharmaceutical compositions for oral administration of growth hormone.
• USE OF ISOSORBIDE ESTER AND N-ACYLATED AMINO ACID DERIVATIVES AS ANTI-AGEING AGENT FOR THE HUMAN SKIN
  申请人：SOCIETE D'EXPLOITATION DE PRODUITS POUR LES INDUSTRIES CHIMIQUES SEPPIC

  公开号：US20170304177A1

  公开（公告）日：2017-10-26

  A compound of formula (I) is disclosed, in which R′ and R″, which may be identical or different, represent either a hydrogen atom or a monovalent radical of formula (IIa); or of a composition (C1) including between 99% and 20% by mass of a compound of formula (Ia), and between 1% and 80% by mass of a compound of formula (1b), with the aim of preventing or retarding the appearance of the signs of ageing of the human skin or lips or to eliminate the signs, the use being in the form of a cosmetic composition. Also disclosed is a method using the product of formula (I) or composition (C1).