1,3-bis(3-morpholinopropyl)urea | 6543-79-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 1,3-bis(3-morpholinopropyl)urea
• 英文别名: N,N'-bis-(3-morpholino-propyl)-urea；N,N'-Bis-(3-morpholino-propyl)-harnstoff；1,3-bis(3-morpholin-4-ylpropyl)urea
• CAS: 6543-79-9
• 化学式: C₁₅H₃₀N₄O₃
• 分子量: 314.428
• InChiKey: XTUPRKONHBQJHJ-UHFFFAOYSA-N

物化性质

• 沸点：
  163-166 °C(Press: 4 Torr)
• 密度：
  1.091±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  66.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (3-morpholino-propyl)-carbamic acid-(2-hydroxy-ethyl ester) 生成 1,3-bis(3-morpholinopropyl)urea
  参考文献：
  名称：

  Delaby et al., Bulletin de la Societe Chimique de France, 1956, p. 831,835

  摘要：

  DOI：

文献信息

• Ruthenium-Catalyzed Urea Synthesis by N–H Activation of Amines
  作者：Varadhan Krishnakumar、Basujit Chatterjee、Chidambaram Gunanathan

  DOI：10.1021/acs.inorgchem.7b00962

  日期：2017.6.19

  observed in situ, which resulted in the formation of CO and dimethylamine. The scope of this new mode of bond activation is extended to the synthesis of urea derivatives from amines using DMF as a carbon monoxide (CO) surrogate. This catalytic protocol allows the synthesis of simple and functionalized urea derivatives with liberation of hydrogen, devoid of any stoichiometric activating reagents, and avoids

  证明了通过“胺-酰胺”金属-配体配合作用的钌夹钳络合物活化了胺的N-H键。N，N的催化甲酰C–H活化在原位观察到-二甲基甲酰胺（DMF），其导致CO和二甲基胺的形成。这种新的键激活模式的范围扩展到了使用DMF作为一氧化碳（CO）替代物由胺合成脲衍生物的范围。该催化方案允许在不释放任何化学计量活化剂的情况下释放氢而合成简单且功能化的尿素衍生物，并且避免直接使用致命性CO。分离出甲酰胺中间体。连续添加不同的胺可提供不对称的脲化合物。提议通过胺的N–H活化，随后DMF中的CO插入和二氢的释放进行反应。
• Reactive catalyst compositions for improving water blown polyurethane foam performance
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0877042A1

  公开（公告）日：1998-11-11

  The present invention provides a reactive catalyst composition for making a water blown flexible polyurethane foam. The catalyst composition comprises a tertiary amino alkyl urea and/or bis(tertiary amino alkyl) urea in combination with either a gelling catalyst or blowing catalyst. The use of such catalyst composition improves the physical properties of the polyurethane foam.

  本发明提供了一种用于制造水发泡软质聚氨酯泡沫的活性催化剂组合物。该催化剂组合物由叔氨基烷基脲和/或双叔氨基烷基脲与胶凝催化剂或发泡催化剂组合而成。使用这种催化剂组合物可以改善聚氨酯泡沫塑料的物理性能。
• Polyurethane catalyst compositions for improving foam perfomance
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP0879837A1

  公开（公告）日：1998-11-25

  A polyurethane catalyst composition comprises N,N-bis(3-dimethylaminopropyl) urea and 3-dimethylaminopropyl urea in a ratio that can be varied to systematically control flowability, airflow, and force-to-crush physical properties for flexible polyurethane foam to enhance processibility. Increasing the N,N-bis(3-dimethylaminopropyl) urea to 3-dimethylaminopropyl urea ratio increases the airflow and decreases the force-to-crush values of the foam whereas decreasing the N,N-bis(3-dimethylaminopropyl) urea to 3-dimethylaminopropyl urea ratio improves the flowability of the foam.

  一种聚氨酯催化剂组合物由 N,N-双（3-二甲基氨基丙基）脲和 3-二甲基氨基丙基脲组成，其比例可以改变，以系统控制软质聚氨酯泡沫的流动性、气流和挤压力物理性能，从而提高加工性能。提高 N,N-双（3-二甲基氨基丙基）脲与 3-二甲基氨基丙基脲的比例可增加气流，降低泡沫的挤压力值，而降低 N,N-双（3-二甲基氨基丙基）脲与 3-二甲基氨基丙基脲的比例则可改善泡沫的流动性。
• Polyurethane catalyst compositions for improving rigid foam performance
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP1059318A2

  公开（公告）日：2000-12-13

  A polyurethane catalyst composition comprises N,N'-bis(3-dimethylaminopropyl) urea and 3-dimethylaminopropyl urea in a ratio that can be varied to systematically control flowability, % open cell content and k-factor value for rigid polyurethane foam to enhance processibility. Increasing the N,N'-bis(3-dimethylaminopropyl) urea to 3-dimethylaminopropyl urea ratio decreases the open cell content and k-factor value of the foam whereas decreasing the N,N'-bis(3-dimethylaminopropyl) urea to 3-dimethylaminopropyl urea ratio improves the flowability of the foaming composition.

  一种聚氨酯催化剂组合物由 N,N'-双(3-二甲基氨基丙基)脲和 3-二甲基氨基丙基脲组成，其比例可以改变，以系统控制硬质聚氨酯泡沫的流动性、开孔率和 k 因子值，从而提高加工性能。提高 N,N'-双（3-二甲基氨基丙基）脲与 3-二甲基氨基丙基脲的比例会降低泡沫的开孔率和 k 因子值，而降低 N,N'-双（3-二甲基氨基丙基）脲与 3-二甲基氨基丙基脲的比例则会提高发泡组合物的流动性。
• Low acid organometallic catalyst for the production of flexible, semi-flexible and rigid polyurethane foams
  申请人：AIR PRODUCTS AND CHEMICALS, INC.

  公开号：EP1443065A1

  公开（公告）日：2004-08-04

  The present invention relates to an improvement in flexible, semi-flexible and rigid foams formed by the catalytic reaction of an aromatic polyisocyanate, a polyol and a blowing agent and a process for preparing such polyisocyanate. The improvement resides in using an effective amount of a bismuth carboxylate or bismuth sulfonate having less than 34% free acid as the catalyst.

  本发明涉及芳香族多异氰酸酯、多元醇和发泡剂催化反应形成的软质、半软质和硬质泡沫的改进，以及制备这种多异氰酸酯的工艺。改进之处在于使用了有效量的游离酸小于 34% 的羧酸铋或磺酸铋作为催化剂。