5-Butyl-3-(4-methylphenyl)sulfonyl-1,3-oxazolidin-2-one | 1236280-27-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Butyl-3-(4-methylphenyl)sulfonyl-1,3-oxazolidin-2-one
• CAS: 1236280-27-5
• 化学式: C₁₄H₁₉NO₄S
• 分子量: 297.375
• InChiKey: NJGBSKYLZXCRMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-己烯 、 二氧化碳 、 chloroamine-T 在 四丁基溴化铵 、 tetra-N-butylammonium tribromide 、 对苯二酚 作用下， 以 乙腈 为溶剂， 100.0 ℃ 、8.0 MPa 条件下， 反应 24.0h， 以6%的产率得到2-butyl-N-tosylaziridine
  参考文献：
  名称：

  Facile synthesis of oxazolidinones catalyzed by n-Bu4NBr3/n-Bu4NBr directly from olefins, chloramine-T and carbon dioxide

  摘要：

  A binary catalyst system composed of n-Bu4NBr3/n-Bu4NBr was developed for facile synthesis of 5-substituted 2-oxazolidinones with perfect regioselectivity in a single operation directly from olefins, chloramine-T and CO2. The choice of efficient binary catalysts for two steps, i.e. aziridination and cycloaddition, and the optimization of reaction condition are keys to the one-pot synthesis of 5-substituted 2-oxazolidinones. A possible mechanism for the present one-pot synthesis of oxazolidinones was also proposed. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.catcom.2010.04.003

文献信息

• Facile synthesis of oxazolidinones catalyzed by n-Bu4NBr3/n-Bu4NBr directly from olefins, chloramine-T and carbon dioxide
  作者：De-Lin Kong、Liang-Nian He、Jin-Quan Wang

  DOI：10.1016/j.catcom.2010.04.003

  日期：2010.6

  A binary catalyst system composed of n-Bu4NBr3/n-Bu4NBr was developed for facile synthesis of 5-substituted 2-oxazolidinones with perfect regioselectivity in a single operation directly from olefins, chloramine-T and CO2. The choice of efficient binary catalysts for two steps, i.e. aziridination and cycloaddition, and the optimization of reaction condition are keys to the one-pot synthesis of 5-substituted 2-oxazolidinones. A possible mechanism for the present one-pot synthesis of oxazolidinones was also proposed. (C) 2010 Elsevier B.V. All rights reserved.