N-phenethyl-2-propylpentanamide | 2936-17-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-phenethyl-2-propylpentanamide
• 英文别名: N-(2-phenylethyl)-2-propylpentanamide
• CAS: 2936-17-6
• 化学式: C₁₆H₂₅NO
• 分子量: 247.381
• InChiKey: YUULYNUNKFUCPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  丙戊酰胺 、 2-苯乙胺 在 niobium(V) oxide 作用下， 以 neat (no solvent) 为溶剂， 以15%的产率得到N-phenethyl-2-propylpentanamide
  参考文献：
  名称：

  介孔氧化铌球作为伯酰胺与胺转氨的有效催化剂

  摘要：

  AbstractMesoporous niobium oxide spheres (MNOS), conveniently prepared by a novel antisolvent precipitation approach, have been shown to be an effective catalyst for the transamidation of primary amides with amines. This novel transamidation can be efficiently carried out under solvent‐free conditions and is applicable to a wide range of primary amides and amines to provide N‐alkyl amides in good to excellent yields. The catalyst is highly stable and reusable. The application of this transamidation reaction has been demonstrated in the synthesis of antidepressant drug moclobemide and other drug‐like compounds.magnified image

  DOI：

  10.1002/adsc.201300717

文献信息

• Mesoporous Niobium Oxide Spheres as an Effective Catalyst for the Transamidation of Primary Amides with Amines
  作者：Subhash Chandra Ghosh、Cheng Chao Li、Hua Chun Zeng、Joyce S. Y. Ngiam、Abdul M. Seayad、Anqi Chen

  DOI：10.1002/adsc.201300717

  日期：2014.2.10

  AbstractMesoporous niobium oxide spheres (MNOS), conveniently prepared by a novel antisolvent precipitation approach, have been shown to be an effective catalyst for the transamidation of primary amides with amines. This novel transamidation can be efficiently carried out under solvent‐free conditions and is applicable to a wide range of primary amides and amines to provide N‐alkyl amides in good to excellent yields. The catalyst is highly stable and reusable. The application of this transamidation reaction has been demonstrated in the synthesis of antidepressant drug moclobemide and other drug‐like compounds.magnified image