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isopropyl-(5-methoxy-2-pyridin-2-yl-pyrimidin-4-yl)-amine | 338771-57-6

中文名称
——
中文别名
——
英文名称
isopropyl-(5-methoxy-2-pyridin-2-yl-pyrimidin-4-yl)-amine
英文别名
N-isopropyl-5-methoxy-2-(2-pyridinyl)-4-pyrimidinamine;5-methoxy-N-propan-2-yl-2-pyridin-2-ylpyrimidin-4-amine
isopropyl-(5-methoxy-2-pyridin-2-yl-pyrimidin-4-yl)-amine化学式
CAS
338771-57-6
化学式
C13H16N4O
mdl
——
分子量
244.296
InChiKey
VGIYTWUCLMICKF-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    1.9
  • 重原子数:
    18
  • 可旋转键数:
    4
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.31
  • 拓扑面积:
    59.9
  • 氢给体数:
    1
  • 氢受体数:
    5

反应信息

  • 作为反应物:
    描述:
    isopropyl-(5-methoxy-2-pyridin-2-yl-pyrimidin-4-yl)-amine柠檬酸异丙醇 为溶剂, 以97%的产率得到isopropyl-(5-methoxy-2-pyridin-2-yl-pyrimidin-4-yl)-ammonium citrate
    参考文献:
    名称:
    USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS
    摘要:
    这项发明涉及一种TRPM8调节剂,用于在皮肤或粘膜上产生降温效果。
    公开号:
    US20120263659A1
  • 作为产物:
    描述:
    参考文献:
    名称:
    USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS
    摘要:
    这项发明涉及一种TRPM8调节剂,用于在皮肤或粘膜上产生降温效果。
    公开号:
    US20120263659A1
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文献信息

  • BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
    申请人:SENOMYX, INC.
    公开号:US20160376263A1
    公开(公告)日:2016-12-29
    The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.
    本发明涵盖已知用于改变苦味感知的化合物和组合物,以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种:冷却剂;无活性药物成分;活性药用成分;食品添加剂或食品;调味剂或调味增强剂;食品或饮料产品;苦味化合物;甜味剂;苦味剂;酸味调味剂;咸味调味剂;鲜味调味剂;植物或动物产品;已知用于宠物护理产品中的化合物;已知用于个人护理产品中的化合物;已知用于家用产品中的化合物;制药制剂;局部制剂;大麻衍生或与大麻相关的产品;已知用于口腔护理产品中的化合物;饮料;香味、香水或除臭剂;已知用于消费品中的化合物;硅化合物;磨料;表面活性剂;发热剂;吸烟物品;脂肪、油脂或乳化剂;和/或益生菌或补充剂。
  • Novel Pyrimidine- And Triazine-Hepcidine Antagonists
    申请人:Dürrenberger Franz
    公开号:US20120202806A1
    公开(公告)日:2012-08-09
    The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders such as, in particular, iron deficiency diseases and anaemia, in particular anaemia associated with chronic inflammatory disease (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
    本发明涉及新的肝铁蛋白拮抗剂,包含它们的药物组合物以及将其用作药物的用途,特别是用于治疗铁代谢紊乱,如特别是铁缺乏病和贫血,特别是与慢性炎症性疾病相关的贫血(ACD:慢性疾病性贫血和AI:炎症性贫血)。
  • USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS
    申请人:BASF SE
    公开号:US20200190052A1
    公开(公告)日:2020-06-18
    The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.
    该发明主要涉及一种调制方法,优选是体外和/或体内调制寒冷薄荷醇受体TRPM8的方法,其中受体与本文描述的结构类型1的化合物群中至少一种调制剂接触。本发明还涉及相关用途和包含这些化合物的组合物。
  • COMPOUNDS USEFUL AS MODULATORS OF TRPM8
    申请人:Senomyx, Inc.
    公开号:US20170096418A1
    公开(公告)日:2017-04-06
    The present disclosure relates to compounds which are useful as cooling sensation compounds.
    本公开涉及作为冷感化合物有用的化合物。
  • A METHOD FOR ENHANCING THE COOLING EFFECT OF A COOLING COMPOUND
    申请人:Symrise AG
    公开号:EP3434330A1
    公开(公告)日:2019-01-30
    Suggested is a method for enhancing the cooling effect of a cooling substance on the skin or a mucous membrane encompassing the following steps: (a) providing specific polyols; (b) providing physiological cooling compounds; (c) blending said with said physiological cooling compounds, and (d) bringing said blend into contact with skin or mucous membranes.
    建议一种增强冷却物质对皮肤或粘膜的冷却效果的方法,包括以下步骤: (a) 提供特定的多元醇 (b) 提供生理性冷却化合物; (c) 将所述物质与所述生理性冷却化合物混合,以及 (d) 使所述混合物与皮肤或粘膜接触。
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