7-dodecyloxy-4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | 1204769-49-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 7-dodecyloxy-4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
• 英文别名: 7-(Dodecyloxy)-4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid；7-dodecoxy-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid
• CAS: 1204769-49-2
• 化学式: C₂₇H₃₂O₇
• 分子量: 468.547
• InChiKey: WWYHXVKECLOLKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  大黄素 在 吡啶 、 四丁基高锰酸胺盐 、 sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.25h， 生成 7-dodecyloxy-4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
  参考文献：
  名称：

  Synthesis and hypoglycemic activity evaluation of 7-alkoxyl-rhein

  摘要：

  A four-step microwave-assisted procedure was used to synthesize 7-alkoxyl-rhein derivatives 5a-e starting from emodin and 1-bromoalkanes. These compounds exhibited hypoglycemic activity by inhibiting alpha-glucosaccharase, which were influenced by the aliphatic chain length. Results showed that 5c displayed remarkable activity in vitro and in vivo.

  DOI：

  10.1007/s00044-010-9511-2

文献信息

• Synthesis and hypoglycemic activity evaluation of 7-alkoxyl-rhein
  作者：Xiaokang Zhu、Xiaoli Ye、Lujiang Yuan、Yangping Ding、Baoshun Zhang、Xuegang Li

  DOI：10.1007/s00044-010-9511-2

  日期：2012.4

  A four-step microwave-assisted procedure was used to synthesize 7-alkoxyl-rhein derivatives 5a-e starting from emodin and 1-bromoalkanes. These compounds exhibited hypoglycemic activity by inhibiting alpha-glucosaccharase, which were influenced by the aliphatic chain length. Results showed that 5c displayed remarkable activity in vitro and in vivo.