4-chlorophenyl carbamate | 5724-99-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chlorophenyl carbamate
• 英文别名: Carbamidsaeure-(p-chlorphenyl)-ester；Carbamidsaeure-<4-chlorphenylester>；(4-chlorophenyl) carbamate
• CAS: 5724-99-2
• 化学式: C₇H₆ClNO₂
• 分子量: 171.583
• InChiKey: CCENBZDJMALWCH-UHFFFAOYSA-N

物化性质

• 熔点：
  142 °C
• 沸点：
  317.2±34.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  4-chlorophenyl carbamate 在 dirhodium tetraacetate 、 碘苯二乙酸 、 magnesium oxide 作用下， 以 甲苯 为溶剂， 以71%的产率得到氯唑沙宗
  参考文献：
  名称：

  铑（II）催化的非定向和选择性C（sp 2）–H胺化反应生成苯并恶唑酮

  摘要：

  铑（II）可以通过分子内的氮杂C–H插入反应有效地促进芳基氨基甲酸酯底物的活化和环化，从而生成苯并恶唑啉酮。对底物范围的研究表明，该反应在更不稳定的o -C（sp 3）-H键上进行了选择性芳族C（sp 2）-H胺化反应。反向二次KIE的观察结果（P H / P D = 0.42±0.03）表明，芳族亲电取代机理参与了芳基CH酰胺化反应。

  DOI：

  10.1021/acscatal.6b02237
• 作为产物：
  描述：

  4-chlorophenyl cyanate 在 硫酸 作用下， 生成 4-chlorophenyl carbamate
  参考文献：
  名称：

  Martin,D., Chemische Berichte, 1964, vol. 97, p. 2689 - 2694

  摘要：

  DOI：

文献信息

• SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
  申请人：GLAXOSMITHKLINE LLC

  公开号：US20150152108A1

  公开（公告）日：2015-06-04

  The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本发明涉及新型取代桥式脲化合物，相应的相关类似物，药物组合物以及其使用方法。本发明的抑制素调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和疾病，包括但不限于与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块疾病、炎症、癌症和/或潮红有关的疾病或疾病，以及那些会受益于增加线粒体活性的疾病或疾病。本发明还涉及包含抑制素调节化合物与另一治疗剂组合的组合物。
• NOVEL COMPOUND HAVING MULTIMER STRUCTURE OF XANTHENE DERIVATIVE, COLORING COMPOSITION, INK FOR INKJET RECORDING, METHOD OF INKJET RECORDING, COLOR FILTER, AND COLOR TONER
  申请人：FUJIFILM CORPORATION

  公开号：US20140176653A1

  公开（公告）日：2014-06-26

  There is provided a compound represented by formula (1): in formula (1), L represents a divalent to tetravalent linking group; D represents a residue obtained by removing 1 to 5 hydrogen atoms from a compound represented by formula (2); m represents an integer of 1 to 10, however, each L may be the same with or different from every other L; n represents an integer of 2 to 10, however, each D may be the same with or different from every other D; and in formula (2), each of R 4 to R 24 independently represents a hydrogen atom or a substituent, provided that formula (2) has at least one or more ionic hydrophilic groups.

  提供了一种由公式(1)表示的化合物：在公式(1)中，L代表二价到四价的连接基团；D代表通过从由公式(2)表示的化合物中去除1到5个氢原子获得的残基；m代表1到10的整数，但是，每个L可以相同也可以不同于其他L；n代表2到10的整数，但是，每个D可以相同也可以不同于其他D；在公式(2)中，R4到R24中的每一个独立地代表一个氢原子或一个取代基，前提是公式(2)至少有一个或更多的离子亲水基团。
• [EN] AZO PIGMENTS, AND PIGMENT DISPERSION, COLORING COMPOSITION AND INK FOR INKJET RECORDING CONTAINING THE AZO PIGMENT<br/>[FR] PIGMENTS AZOÏQUES, DISPERSION DE PIGMENTS, COMPOSITION COLORANTE ET ENCRE POUR IMPRESSION À JET D'ENCRE CONTENANT LE PIGMENT AZOÏQUE
  申请人：FUJIFILM CORP

  公开号：WO2009110643A1

  公开（公告）日：2009-09-11

  Provided is an azo pigment represented by the following general formula (1), a tautomer of the azo pigment, and a salt or a hydrate thereof: General formula (1) wherein Q represents the non-metallic atoms necessary to complete a 5- to 7-membered heterocyclic group, W represents an alkoxy group, an amino group, an alkyl group, or an aryl group, X1 and X2 each independently represents a hydrogen, an alkyl group, an acyl group, an alkylsulfonyl group, or an arylsulfonyl group, R1 represents a hydrogen or a substituent, R2 represents a heterocyclic group, n represents an integer of from 1 to 4 and the general formula (1) represents a dimer formed through Q, W, X1, X2, R1, or R2 when n=2, a trimer formed through Q, W, X1, X2, R1, or R2 when n=3, and a tetramer formed through Q, W, X1, X2, R1, or R2 when n=4.

  提供的是以下一般式（1）所代表的偶氮颜料，偶氮颜料的互变异构体，以及其盐或水合物：一般式（1）中，Q代表必要的非金属原子，以完成一个5-至7-成员杂环基团，W代表烷氧基、氨基、烷基或芳基，X1和X2分别独立地代表氢、烷基、酰基、烷基磺酰基或芳基磺酰基，R1代表氢或取代基，R2代表杂环基团，n代表1至4的整数，一般式（1）代表当n=2时通过Q、W、X1、X2、R1或R2形成的二聚体，当n=3时通过Q、W、X1、X2、R1或R2形成的三聚体，以及当n=4时通过Q、W、X1、X2、R1或R2形成的四聚体。
• Sulphonamido-substituted bridged bicycloalkyl derivatives
  申请人：——

  公开号：US20040029862A1

  公开（公告）日：2004-02-12

  A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease.

  揭示了一类化合物，包括磺胺基取代的桥联双环烷基结构。这些化合物是γ-分泌酶的抑制剂，因此在治疗和/或预防阿尔茨海默病方面是有用的。
• Process for the preparation of asymmetrically substituted ureas,
  申请人：Chemie Linz Gesellschaft m.b.H.

  公开号：US05248755A1

  公开（公告）日：1993-09-28

  Process for the preparation of asymmetrically substituted ureas, carbamates, thiocarbamates or substituted isocyanates by reaction of an adduct of isocyanic acid and a tertiary amine with a primary and secondary amine, an alcohol, a thiol or a compound having one or two non-cumulated olefinic double bonds, and a process for the preparation of N-mono- or N,N-disubstituted ureas by reaction of ammonium isocyanate with a primary or secondary amine in a diluent.

  通过将异氰酸和三级胺的加合物与一级和二级胺、醇、硫醇或具有一个或两个非累积烯烃双键的化合物反应，制备不对称取代脲、碳酸酯、硫代碳酸酯或取代异氰酸的方法，以及通过在稀释剂中将铵异氰酸与一级或二级胺反应制备N-单取代或N,N-二取代脲的方法。