Indicaxanthin | 94983-34-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Indicaxanthin
• 英文别名: (2S)-1-[(2E)-2-[(2S)-2,6-dicarboxy-2,3-dihydro-1H-pyridin-4-ylidene]ethylidene]pyrrolidin-1-ium-2-carboxylate
• CAS: 94983-34-3
• 化学式: C₁₄H₁₆N₂O₆
• 分子量: 308.291
• InChiKey: RJIIQBYZGJSODH-QWRGUYRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  130
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
  申请人：Bapat Abhijit S.

  公开号：US20140364595A1

  公开（公告）日：2014-12-11

  The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; or (iv) (AFA) m″ -X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.

  该发明提供了由至少一种抗真菌剂或抗菌剂与至少一种连接剂和/或载体偶联形成的基于共轭的抗真菌或抗菌前药。这些前药的公式为：(i) (AFA) m -X-(L) n ; (ii) [(AFA) m′ -X] p -L; (iii) AFA-[X-(L) n′ ] q ; 或 (iv) (AFA) m″ -X，其中：AFA是抗真菌剂或抗菌剂；L是载体；X是连接剂；m范围从1到10；n范围从2到10；m′为1到10；p为1到10；n′为1到10；q为1到10，前提是q'和n不同时为1；m″为1到10。该发明还提供了包含基于共轭的前药的纳米粒子。此外，该发明还提供了以纳米粒子形式的非共轭抗真菌和抗菌剂。
• In Vitro Synthesis of Betaxanthins Using Recombinant DOPA 4,5-Dioxygenase and Evaluation of Their Radical-Scavenging Activities
  作者：Hiroshi Sekiguchi、Yoshihiro Ozeki、Nobuhiro Sasaki

  DOI：10.1021/jf1030086

  日期：2010.12.8

  for proline-betaxanthin. Twenty-four betaxanthin species were synthesized by the condensation reaction of purified betalamic acid and amino acids or amines. An HPLC protocol was established for identifying the different betaxanthin species. Proline-, dopamine-, and γ-aminobutyric acid (GABA)-betaxanthins were prepared as representative betaxanthins under large-scale conditions, and their 1,1-diphe

  使用重组Mirabilis jalapa从1-二羟基苯丙氨酸（L-DOPA）大规模酶促合成了虾青素的发色团β-丙二酸。DOPA 4,5-二加氧酶。合成后，将脯氨酸直接添加到浓缩的反应混合物中以生成脯氨酸-甜菜黄素。纯化产物的分子量和核磁共振谱与先前报道的脯氨酸-甜菜黄素的分子量和核磁共振谱相同。通过纯化的铍金属与氨基酸或胺的缩合反应合成了二十四种虾青素。建立了用于鉴定不同虾青素种类的HPLC方案。在大规模条件下，制备了脯氨酸，多巴胺和γ-氨基丁酸（GABA）-甜菜黄素作为代表性的虾青素，并将它们的1,1-二苯基-2-吡啶并肼基自由基清除活性与已知的抗氧化剂进行了比较。GABA-甜菜黄素显示相对较低的活性，而多巴胺-甜菜黄素的活性与红色素甜菜碱和花青素花青素3-葡糖苷相似。脯氨酸-β-黄嘌呤具有三种合成化合物中最高的活性，与类黄酮槲皮素相似。
• [EN] INHIBITING HYDROCARBON HYDRATE AGGLOMERATION<br/>[FR] INHIBITION DE L'AGGLOMÉRATION D'HYDRATES D'HYDROCARBURES
  申请人：COMMW SCIENT IND RES ORG

  公开号：WO2018218281A1

  公开（公告）日：2018-12-06

  A process for inhibiting the formation of gas hydrates in a hydrocarbon fluid comprising adding to the hydrocarbon fluid, a gas hydrate anti-agglomerate which is a biodegradable anti-agglomerant derived from a naturally occurring substance.

  一种抑制碳氢化合物流体中天然气水合物形成的方法包括向碳氢化合物流体中添加一种气体水合物抗凝聚剂，该抗凝聚剂是一种可生物降解的抗凝聚剂，来源于天然存在的物质。
• 2,3- and 4,5-Secodopa, the Biosynthetic Intermediates Generated fromL-Dopa by an Enzyme System Extracted from the Fly Agaric,Amanita muscaria L., and Their Spontaneous Conversion to Muscaflavin and Betalamic Acid, Respectively, and Betalains
  作者：Fernand Terradas、Hugo Wyler

  DOI：10.1002/hlca.19910740115

  日期：1991.1.30

  An enzyme is extracted from the red peel of Amanita muscaria which cleaves the C(2)–C(3) and the C(4)–C(5) bond of the aromatic ring of L-dopa (1) to form a mixture of 4,5-secodopa (= salt of 6-amino-2-hydroxy-4-(2′-oxoethylidene)hept-2-enedioic acid; 2) and 2,3-secodopa ( = salt of 7-amino-5-formyl-2-hydroxyocta-2,4-dienedioic acid; 3), two hitherto hypothetical biosynthetic intermediates (see Scheme)

  从毒蝇伞的红皮中提取一种酶，该酶切割L-多巴（1）芳香环的C（2）–C（3）和C（4）–C（5）键，形成混合物4,5-secodopa（= 6-氨基-2-羟基-4-（2'-氧代亚乙基）庚-2-烯二酸的盐; 2）和2,3-secodopa（= 7-氨基-5的盐-甲酰基-2-羟基辛基-2,4-二烯二酸；3），两个迄今假设的生物合成中间体（参见方案）。尽管不可能分离出这些产物，但与已知化合物相比，可以从反应产物，动力学和光谱特征中推断出结构证据。Secodopas 2和3的特征在于，通过HPLC和UV / VIS光谱稀溶液（阴离子;λ最大。424和414纳米，RESP，ε 420 = 25500;关于酸化，转移到380和372纳米，RESP）。它们可以在没有酶催化的情况下进行环化，最佳的pH值为4.5-5。3产生muscaflavin（5）和2 betalamic acid（4）。通过与HPLC中的真实样品直接比较，1
• FAT-BINDING COMPOSITIONS
  申请人：SZENTE Lajos

  公开号：US20110224168A1

  公开（公告）日：2011-09-15

  A fat-binding composition contains an inclusion complex with a host molecule and a guest molecule. The guest molecule includes one or more amino acids, vitamins, flavorants or related compounds, rutin, betanin, derivatives thereof, and mixtures thereof. The fat-binding composition may be in the form of a tablet or powder, for example, and may be incorporated into a food or beverage product. If in the form of a powder or tablet, the composition may optionally contain a carbonation-forming component and may be dissolved in carbonated or non-carbonated water. The fat-binding composition may also be employed in a method for binding fat ingested by an animal which includes having the animal ingest the composition, or a food or beverage product containing the same.

  一种脂肪结合组合物包含一个主体分子和一个客体分子的包含复合物。客体分子包括一个或多个氨基酸、维生素、调味剂或相关化合物、芦丁、甜菜红素、其衍生物和混合物。脂肪结合组合物可以是以片剂或粉末的形式存在，并可以被加入到食品或饮料产品中。如果以粉末或片剂的形式存在，该组合物可以选择性地包含一个生成碳酸的组分，并可以溶解在含或不含碳酸的水中。脂肪结合组合物还可以用于结合动物摄入的脂肪的方法，包括让动物摄入该组合物，或含有该组合物的食品或饮料产品。