isopropyl 2-(dimethylamino)acetate | 119152-80-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: isopropyl 2-(dimethylamino)acetate
• 英文别名: propan-2-yl 2-(dimethylamino)acetate
• CAS: 119152-80-6
• 化学式: C₇H₁₅NO₂
• mdl: MFCD16041599
• 分子量: 145.202
• InChiKey: YJEIQHSKMASLBX-UHFFFAOYSA-N

物化性质

• 沸点：
  159.5±23.0 °C(Predicted)
• 密度：
  0.935±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二甲基甘氨酸 、 异丙醇 在 盐酸 作用下， 反应 12.0h， 以78%的产率得到isopropyl 2-(dimethylamino)acetate
  参考文献：
  名称：

  A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir

  摘要：

  An efficient route towards biologically relevant pentose derivatives is described. The de novo synthetic strategy features an enantioselective alpha-oxidation reaction enabled by a chiral amine in conjunction with copper(II) catalysis. A subsequent Mukaiyama aldol coupling allows for the incorporation of a wide array of modular two-carbon fragments. Lactone intermediates accessed via this route provide a useful platform for elaboration, as demonstrated by the preparation of a variety of C-nucleosides and fluorinated pentoses. Finally, this work has facilitated expedient syntheses of pharmaceutically active compounds currently in clinical use.

  DOI：

  10.1021/ja502205q

文献信息

• mTORC modulators and uses thereof
  申请人：Aeovian Pharmaceuticals, Inc.

  公开号：US11021492B2

  公开（公告）日：2021-06-01

  Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.

  本文公开了新型雷帕霉素类似物及其用途。 与雷帕霉素相比，本公开的雷帕霉素类似物显示出更高的 mTORC1 特异性和更低的 mTORC2 特异性。
• SOLUBLE C5aR ANTAGONISTS
  申请人：CHEMOCENTRYX, INC.

  公开号：US20170283446A1

  公开（公告）日：2017-10-05

  Compounds are provided to modulate the C5a receptor. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 and R 3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
• MTORC MODULATORS AND USES THEREOF
  申请人：Aeovian Pharmaceuticals, Inc.

  公开号：US20210002300A1

  公开（公告）日：2021-01-07

  Novel rapamycin analogs and uses thereof are disclosed herein. The rapamycin analogs of the present disclosure show increased mTORC1 specificity and lowered mTORC2 specificity relative to rapamycin.
• US8044230B2
  申请人：——

  公开号：US8044230B2

  公开（公告）日：2011-10-25
• A General and Enantioselective Approach to Pentoses: A Rapid Synthesis of PSI-6130, the Nucleoside Core of Sofosbuvir
  作者：Manuel Peifer、Raphaëlle Berger、Valerie W. Shurtleff、Jay C. Conrad、David W. C. MacMillan

  DOI：10.1021/ja502205q

  日期：2014.4.23

  An efficient route towards biologically relevant pentose derivatives is described. The de novo synthetic strategy features an enantioselective alpha-oxidation reaction enabled by a chiral amine in conjunction with copper(II) catalysis. A subsequent Mukaiyama aldol coupling allows for the incorporation of a wide array of modular two-carbon fragments. Lactone intermediates accessed via this route provide a useful platform for elaboration, as demonstrated by the preparation of a variety of C-nucleosides and fluorinated pentoses. Finally, this work has facilitated expedient syntheses of pharmaceutically active compounds currently in clinical use.