3-methoxy-2-methylacryloyl chloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯酯类
• 英文名称: 3-methoxy-2-methylacryloyl chloride
• 英文别名: (E)-3-methoxy-2-methylpropenoyl chloride；(E)-3-methoxy-2-methylprop-2-enoyl chloride
• 化学式: C₅H₇ClO₂
• 分子量: 134.562
• InChiKey: JQWNCTPZTFWJLR-ONEGZZNKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methoxy-2-methylacryloyl chloride 以 1,4-二氧六环 、 甲苯 为溶剂， 反应 1.83h， 生成 ethyl N-[(E)-3-methoxy-2-methylprop-2-enoyl]carbamate
  参考文献：
  名称：

  (1S,2R)-[(Benzyloxy)methyl]cyclopent-3-enol. A Versatile Synthon for the Preparation of 4‘,1‘a-Methano- and 1‘,1‘a-Methanocarbocyclic Nucleosides

  摘要：

  DOI：

  10.1021/jo962124t
• 作为产物：
  描述：

  3-甲氧基甲基丙烯酸甲酯 在 氯化亚砜 作用下， 生成 3-methoxy-2-methylacryloyl chloride
  参考文献：
  名称：

  从环戊二烯到异恶唑啉-碳环核苷：通过亚硝基羰基化学快速获取生物分子

  摘要：

  提议从环戊二烯开始快速获得含有稠合的异恶唑啉环的碳环核苷。该路线涉及亚硝基羰基苯的杂Diels-Alder环加成反应，然后是腈的1，3-偶极环加成，N-O链断裂，以及通过嘌呤和嘧啶杂环的线性构建将杂环氨基分解为核苷。

  DOI：

  10.1016/j.tet.2004.02.057

文献信息

• Linked peptide nucleic acids
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US06441130B1

  公开（公告）日：2002-08-27

  Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

  新型肽核酸和新型连接的肽核酸与核酸形成三股结构。肽核酸包括配体，例如通过适当的连接剂连接到肽骨架上的天然存在的核碱基。其他核碱基，包括C-嘧啶和异嘧啶，可以用作胡格斯块链中的配体，以增加结合亲和力。两条肽核酸链通过连接剂连接在一起形成双肽核酸。双化合物中肽核酸的单条链可以平行或反平行定向。
• [EN] PHOSPHONUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISORDERS<br/>[FR] PHOSPHONUCLÉOSIDES UTILES DANS LE TRAITEMENT DE TROUBLES VIRAUX
  申请人：UNIV CORK

  公开号：WO2014079903A1

  公开（公告）日：2014-05-30

  A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or prodrug thereof, wherein the groups are as defined in the claims. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula (I), and the use of compounds of formula (I) in the preparation of a medicament for treating a viral disorder.

  本发明的第一个方面涉及式(I)的化合物，或其药学上可接受的盐或前药，其中所述基团如权利要求中所定义。本发明的进一步方面涉及包括式(I)化合物的药物组合物，以及使用式(I)化合物制备治疗病毒性疾病的药物。
• 1-(2-Deoxy-α- and β-D-erythro-pentofuranosyl)-2-(thymin-1-yl)ethane derivatives as conformational probes for altDNA oligonucleotides
  作者：Carlo L. Scremin、Jila H. Boal、Andrzej Wilk、Lawrence R. Phillips、Liang Zhou、Serge L. Beaucage

  DOI：10.1016/0040-4039(95)01932-8

  日期：1995.12

  The novel deoxyribonucleoside analogues 1a,b have been synthesized in a straightforward manner from 2-deoxy-D-ribose. These modified nucleosides have also been converted to the phosphoramidite derivatives 13a,b and 14a,b for potential incorporation into oligodeoxyribonucleotides according to defined intemucleotidic motifs.

  新颖的脱氧核糖核苷类似物1a，b已经以直接的方式由2-脱氧-D-核糖合成。这些修饰的核苷也已经被转化为亚磷酰胺衍生物13a，b和14a，b，以根据限定的核酸间基序潜在地掺入寡脱氧核糖核苷酸中。
• Synthesis of Nucleosides and Related Compounds. Part XX. Synthesis of Carbocyclic Nucleosides from 2-Azabicyclo(2.2.1)hept-5-en-3-ones: Sodium Borohydride-Mediated Carbon-Nitrogen Bond Cleavage of Five-and Six-Membered Lactams.
  作者：Nobuya KATAGIRI、Makoto MUTO、Masahiro NOMURA、Tohru HIGASHIKAWA、Chikara KANEKO

  DOI：10.1248/cpb.39.1112

  日期：——

  Various carbocyclic ribofuranosyl nucleosides were stereoselectively synthesized through a small number of steps from 2-azabicyclo[2.2.1]hept-5-en-3-ones by the use of sodium borohydride-mediated C-N bond cleavage as a key step. Ready availability of a novel synthetic precursor, (±)-4β-hydroxymethyl-1β-ureidocyclopentane-2α, 3α-diol [(±)-carbocyclic ribofuranosylurea], provides not only facile routes to carbocyclic robofuranosylpyrimidines, but also another route to the corresponding cyclopentylamine, (±)-1β-amino-4β-hydroxymethylcyclopentane-2α, 3α-diol [(±)-carbocyclic ribofuranosylamine], which is useful for the synthesis of the corresponding purine nucleosides.

  通过利用硼氢化钠介导的C-N键断裂作为关键步骤，从2-氮杂双环[2.2.1]庚-5-烯-3-酮出发，经过少量步骤，立体选择性地合成了多种碳环核糖呋喃糖苷核苷。新型合成前体(±)-4β-羟甲基-1β-脲基环戊烷-2α, 3α-二醇[(±)-碳环核糖呋喃糖苷脲]的易得性，不仅提供了通往碳环核糖呋喃糖苷嘧啶的便捷途径，还提供了另一种途径，即合成相应的环戊胺，(±)-1β-氨基-4β-羟甲基环戊烷-2α, 3α-二醇[(±)-碳环核糖呋喃糖苷胺]，这对于相应嘌呤核苷的合成非常有用。
• Dideoxycarbocyclic nucleosides
  申请人：Regents of the University of Minnesota

  公开号：US04916224A1

  公开（公告）日：1990-04-10

  Antiviral and antitumor compounds are disclosed of general formula: ##STR1## wherein Z is H, OH or NH.sub.2, Y is CH or N, the bond indicated by C.sub.1 '--C.sub.2 ' is absent or, in combination with the C.sub.1 '--C.sub.2 ' bond is the unit CH.dbd.CH, and X is selected from the group consisting of H, N(R.sub.2), SR, OR or halogen, wherein R is H, lower (C.sub.1 -C.sub.4)alkyl, aryl or mixtures thereof, and the pharmaceutically acceptable salts thereof.

  抗病毒和抗肿瘤化合物的一般公式为：##STR1## 其中 Z 为 H、OH 或 NH2，Y 为 CH 或 N，由 C1'--C2' 指示的键缺失或者与 C1'--C2' 键组合为 CH.dbd.CH 单元，X 选自 H、N(R2)、SR、OR 或卤素的组，其中 R 为 H、较低的（C1-C4）烷基、芳基或它们的混合物，以及其药用盐。