N,N,N',N'-Tetramethylfumarsaeurediamid | 17878-64-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N,N',N'-Tetramethylfumarsaeurediamid
• 英文别名: N,n,n',n'-tetramethylfumaramide；(E)-N,N,N',N'-tetramethylbut-2-enediamide
• CAS: 17878-64-7
• 化学式: C₈H₁₄N₂O₂
• 分子量: 170.211
• InChiKey: KBRJTGNCPIFGFI-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N,N',N'-Tetramethylfumarsaeurediamid 以94%的产率得到
  参考文献：
  名称：

  HOFFMANN R.; HARTKE K., CHEM. BER., 1980, 113, NO 3, 919-933

  摘要：

  DOI：
• 作为产物：
  描述：

  马来酸酐 以 水 、 丙酮 为溶剂， 生成 N,N,N',N'-Tetramethylfumarsaeurediamid
  参考文献：
  名称：

  Synthesis of amides

  摘要：

  从环状酐、羧酸及其酯与胺氨基酸盐接触合成了烷基酰胺。

  公开号：

  US04379928A1

文献信息

• Production process of N-substituted amide compounds
  申请人：Mitsui Chemicals, Incorporated

  公开号：US04835312A1

  公开（公告）日：1989-05-30

  An N-substituted amide compound is produced with a high yield by initiating a reaction among a starting amide compound such as a saturated or unsaturated, aliphatic or aromatic carboxylic acid amide, a halogen-substituted compound such as an alkyl halide and a strongly basic substance while maintaining the basic substance in a suspended state.

  通过在保持碱性物质悬浮状态的同时在起始酰胺化合物（如饱和或不饱和的脂肪族或芳香族羧酸酰胺）、卤素取代化合物（如烷基卤化物）和强碱性物质之间引发反应，高产率地生产N-取代酰胺化合物。
• NOVEL SPIROOXYINDOLE COMPOUNDS AND DRUGS CONTAINING SAME
  申请人：NAKASHIMA Hisashi

  公开号：US20080306102A1

  公开（公告）日：2008-12-11

  A Spiro oxindole compound represented by formula (1) of the present invention or salt thereof, or their solvate shows a superior inhibitory effect of 11β-hydroxysteroid dehydrogenasel, and is useful as an agent for preventing or treating a disease that involves 11β-hydroxysteroid dehydrogenasel (in particular, diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome).

  本发明的化合物或其盐，或其溶剂化物，由下式（1）表示的螺环氧吲哚化合物，显示出对11β-羟基类固醇脱氢酶的优越抑制作用，并且可用作预防或治疗涉及11β-羟基类固醇脱氢酶的疾病的药剂（特别是糖尿病、胰岛素抵抗、糖尿病并发症、肥胖、血脂异常、高血压、脂肪肝或代谢综合征）。
• NOVEL SPIRO COMPOUND AND MEDICINE COMPRISING THE SAME
  申请人：Nakashima Hisashi

  公开号：US20100022572A1

  公开（公告）日：2010-01-28

  It is to provide a novel compound useful for preventing and/or treating diabetes, insulin resistance, diabetes complication, obesity, dyslipidemia, hypertension, fatty liver, or metabolic syndrome. A spiro compound represented by the following general formula (1) or salt thereof, or their solvate.

  这是为了提供一种新型化合物，用于预防和/或治疗糖尿病、胰岛素抵抗、糖尿病并发症、肥胖、血脂异常、高血压、脂肪肝或代谢综合征。由以下一般式（1）表示的螺环化合物或其盐，或它们的溶剂化合物。
• Hydroxyalkyl cyclic diamine compound
  申请人：Kowa Co., Ltd.

  公开号：US20040176593A1

  公开（公告）日：2004-09-09

  The present invention is directed to a compound represented by the following formula (1) and to a process for producing a compound (5) from the compound (1). 1 By use of the compound (1) of the present invention, a variety of cyclic diamine derivatives (5) or salts thereof, useful as drugs, can be produced in an industrially advantageous manner with a constant yield.

  本发明涉及一种由以下化学式（1）表示的化合物以及从该化合物（1）制备化合物（5）的方法。通过使用本发明的化合物（1），可以以工业上有利的方式稳定产量地生产各种环状二胺衍生物（5）或其盐，这些物质可用作药物。
• 2,4-Bis (trifluoroethoxy)pyridine compound and drug containing the compound
  申请人：Shibuya Kimiyuki

  公开号：US20050020606A1

  公开（公告）日：2005-01-27

  The present invention is directed to a 2,4-bis(trifluoroethoxy)pyridine compound represented by formula (1): (wherein X 1 represents a fluorine atom or a hydrogen atom) or a salt thereof, and to a drug containing the compound or the salt as an active ingredient. The compound has metabolic resistance in human liver microsome, good absorbability upon oral administration, and excellent ACAT inhibitory activity.

  本发明涉及一种由式（1）表示的2,4-双(三氟乙氧基)吡啶化合物（其中X1代表氟原子或氢原子）或其盐，以及包含该化合物或盐作为活性成分的药物。该化合物在人类肝微粒体中具有代谢抵抗性，在口服后具有良好的吸收性，并且具有优异的ACAT抑制活性。