tribenzyl citrate | 631-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tribenzyl citrate
• 英文别名: citric acid tribenzyl ester；Citronensaeure-tribenzylester；Tribenzyl-citrat；2-hydroxy-1,2,3-propanetricarboxylic acid, tris(phenylmethyl) ester；3-hydroxy-pentanedioic acid dibenzyl 3-benzyloxycarbonyl ester；tribenzyl 2-hydroxypropane-1,2,3-tricarboxylate
• CAS: 631-25-4
• 化学式: C₂₇H₂₆O₇
• 分子量: 462.499
• InChiKey: VYLZSGQQVHTICN-UHFFFAOYSA-N

物化性质

• 沸点：
  557.0±40.0 °C(Predicted)
• 密度：
  1.259±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  99.1
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  tribenzyl citrate 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以44%的产率得到1,2-dibenzyl hydrogen citrate
  参考文献：
  名称：

  Katritzky, Alan R.; Fang, Yunfeng; Prakash, Indra, Journal of the Indian Chemical Society, 1999, vol. 76, # 11-12, p. 675 - 677

  摘要：

  DOI：
• 作为产物：
  描述：

  柠檬酸 、 苯甲醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 18.0h， 以100%的产率得到tribenzyl citrate
  参考文献：
  名称：

  WO2007/14471

  摘要：

  公开号：

文献信息

• Monomers, Polymers, Dispersions and Inks
  申请人：LOZMAN Owen Roger

  公开号：US20110040026A1

  公开（公告）日：2011-02-17

  A compound of Formula (1) or a salt thereof: wherein R is H, methyl or ethyl.

  化合物的化学式（1）或其盐：其中R为H、甲基或乙基。
• SUSTAINED RELEASE COMPOSITIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1291023A1

  公开（公告）日：2003-03-12

  A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

  通过含有或混合生理活性非肽物质和具有两个或两个以上羧基末端的可生物降解聚合物或其盐制备的组合物具有以下特点：（1）可以含有更多生理活性非肽物质，并且可以控制或加速其释放，从而实现安全的药效；（2）当生理活性非肽物质引起皮下刺激时，预计具有在其末端具有强酸性基团的活性来取消刺激；以及（3）高玻璃转变温度和高稳定性。
• Hydroxy-oligocarboxylic esters: effects on nerve and use for cutaneous and mucocutaneous organs or sites
  申请人：Yu J. Ruey

  公开号：US20070093551A1

  公开（公告）日：2007-04-26

  A composition and method for producing a beneficial effect on a subject's nerve associated with at least one of a cosmetic condition, a dermatological indication and a dental indication and another condition. The composition comprises a hydroxy-oligocarboxylic ester and is formulated for topical administration of the product to a subject to produce the beneficial effect. The method includes topically applying to the subject in a region where the beneficial effect is desired a hydroxy-oligocarboxylic ester in an amount effective to produce the beneficial effect.

  一种用于产生对与至少一种美容状况、皮肤学指示和牙科指示以及另一种状况相关的主体神经有益作用的组合物和方法。该组合物包含羟基寡聚羧酸酯，并且配制为局部给药形式，以产生有益作用。该方法包括在所需产生有益作用的区域局部施用羟基寡聚羧酸酯，其用量有效地产生有益作用。
• Sustained release compositions
  申请人：——

  公开号：US20040023987A1

  公开（公告）日：2004-02-05

  A composition prepared by containing or blending a physiologically active non-peptide substance and a biodegradable polymer having two or more carboxylic groups at its end or a salt thereof features: (1) larger content of the physiologically active non-peptide substance can be contained, as well as release of the same can be controlled or accelerated, whereby secure pharmaceutical effect is achieved; (2) when the physiologically active non-peptide substance causes subcutaneous stimulation, an activity of canceling the stimulation by strongly acidic group at its end is expected; and (3) high glass transition point and high stability.

  这是一篇有关于含有生理活性非肽物质和生物可降解聚合物的组合物的描述。该生物可降解聚合物在其末端具有两个或多个羧基或其盐，其特点是：（1）可以包含更多生理活性非肽物质，同时可以控制或加速其释放，从而实现安全的药物效果；（2）当生理活性非肽物质引起皮下刺激时，预计其末端的强酸性基团具有消除刺激的作用；（3）具有高玻璃转移温度和高稳定性。
• CHELATING SILICON-BASED POLYMERS
  申请人：Brook Michael

  公开号：US20090118456A1

  公开（公告）日：2009-05-07

  The present invention relates to novel silicon-based polymers, particularly silicon-based polymers having citrate groups, and their use as chelating agents, for forming and as stabilizers.

  本发明涉及新型基于硅的聚合物，特别是具有柠檬酸酯基团的基于硅的聚合物，以及它们作为螯合剂、形成剂和稳定剂的用途。