diethyl 2-tert-butoxycarbonyloxyiminomalonate | 59577-27-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl 2-tert-butoxycarbonyloxyiminomalonate
• 英文别名: diethyl 2-tertbutoxycarbonyloxyiminomalonate；(tert-Butoxycarbonyloxyimino)-malonsaeure-diethylester；diethyl 2-[(2-methylpropan-2-yl)oxycarbonyloxyimino]propanedioate
• CAS: 59577-27-4
• 化学式: C₁₂H₁₉NO₇
• 分子量: 289.285
• InChiKey: WYRIRZDRBQZVRA-UHFFFAOYSA-N

物化性质

• 沸点：
  328.9±25.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  L-丙氨酸 、 diethyl 2-tert-butoxycarbonyloxyiminomalonate 在 三乙胺 作用下， 以 水 、 叔丁醇 为溶剂， 生成 N-叔丁氧羰基-L-丙氨酸
  参考文献：
  名称：

  Peptides. VI. Some Oxime Carbonates as Novelt-Butoxycarbonylating Reagents

  摘要：

  几种肟的叔丁氧羰基衍生物是通过相应的肟基碳酸氯制备的。其中，二乙基（叔丁氧羰氧亚氨基）丙二酸酯和2-（叔丁氧羰氧亚氨基）-2-苯基乙腈被用于在不同条件下制备叔丁氧羰氨基酸。结果总结在一个表格中。

  DOI：

  10.1246/bcsj.50.718
• 作为产物：
  描述：

  光气 、 异亚硝基丙二酸二乙酯 、 叔丁醇 生成 diethyl 2-tert-butoxycarbonyloxyiminomalonate
  参考文献：
  名称：

  Peptides. VI. Some Oxime Carbonates as Novelt-Butoxycarbonylating Reagents

  摘要：

  几种肟的叔丁氧羰基衍生物是通过相应的肟基碳酸氯制备的。其中，二乙基（叔丁氧羰氧亚氨基）丙二酸酯和2-（叔丁氧羰氧亚氨基）-2-苯基乙腈被用于在不同条件下制备叔丁氧羰氨基酸。结果总结在一个表格中。

  DOI：

  10.1246/bcsj.50.718

文献信息

• Carbonic acid esters, and the preparation thereof and their use
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04010178A1

  公开（公告）日：1977-03-01

  Carbonic acid esters of the formula substituent(s) substituents(s) R'.sub.1 OCOOR'.sub.2 wherein R'.sub.1 is lower alkyl which may have substituent)s) selected from the group of halogen, lower alkoxy and aryloxy, or ar(lower)-alkyl which may have substituents)s) selected from the group of lower alkoxy, halogen, nitro and cyano, and R'.sub.2 is benzotriazolyl which may have halogen; or a group represented by the formula: ##STR1## wherein Y' and Z' are each cyano, nitro, carbamoyl, esterified carboxy, lower alkanoyl, aroyl or disubstituted carbamoyl; provided that when R'.sub.2 is a group represented by the formula: ##STR2## wherein Y' and Z' are each cyano, nitro, carbamoyl or esterified carboxy, R'.sub.1 is ar(lower) alkyl having substituent(s) selected from the group of lower alkoxy, halogen, nitro and cyano. A process for the protection of amino and/or imino groups in compounds containing them by reacting them with the aforementioned esters is also disclosed.

  公式中的碳酸酯基团R'.sub.1 OCOOR'.sub.2，其中R'.sub.1是较低的烷基，可能具有来自卤素、较低的烷氧基和芳基的基团，或者是芳基-较低烷基，可能具有来自较低烷氧基、卤素、硝基和氰基的基团；R'.sub.2是苯并三唑基，可能具有卤素；或者是由以下公式表示的基团：##STR1## 其中Y'和Z'分别是氰基、硝基、氨基甲酰基、酯化羧基、较低的烷酰基、芳酰基或二取代的氨基甲酰基；但是当R'.sub.2是由以下公式表示的基团时：##STR2## 其中Y'和Z'分别是氰基、硝基、氨基甲酰基或酯化羧基时，R'.sub.1是芳基-较低烷基，具有来自较低烷氧基、卤素、硝基和氰基的基团。还公开了一种通过将含有氨基和/或亚氨基基团的化合物与上述酯反应来保护它们的方法。
• Oxime carbonates
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04014915A1

  公开（公告）日：1977-03-29

  Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group - containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed.

  揭示了一种新型的碳酸酯，可用于在氨基和/或亚氨基化合物中引入酯化羧基型保护基的过程，以临时保护所述氨基和/或亚氨基。此外，还揭示了制备所述酯的方法。
• Process for protecting amino and/or imino groups
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04083848A1

  公开（公告）日：1978-04-11

  Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group - containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed.

  本发明揭示了一种新型的碳酸酯，可用于在含有氨基和/或亚氨基的化合物中引入酯化羧基型保护基的过程中，对所述氨基和/或亚氨基进行暂时保护。此外，本发明还揭示了制备所述酯的方法。
• Cephem compounds, processes for their preparation and pharmaceutical compositions containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0007633A2

  公开（公告）日：1980-02-06

  A compound of the formula: wherein R1 is amino or protected amino, R2 is lower alkyl substituted with a substituent selected from the groups consisting of cyano, carbamoyl, hydroxy, protected hydroxy. amino. protected amino, lower alkoxy, lower alkylthio, lower alkenylthio, aryl which may have one or more suitable substituent(s). and heterocyclic group which may have one or more suitable substituent(s), R3 is carboxy or functionally modified carboxy, and R4 is hydrogen or halogen and its pharmaceutically acceptable salt and pharmaceutically acceptable bioprecursor thereof and process for their preparation. The invention also relates to a pharmaceutical composition comprising. as an effective ingredient, the above com. pound in association with a pharmaceutically acceptable, substantially nontoxic carrier or excipient. and to a method for treating an infectious disease caused by pathogenes, which comprises administering the above compound to infected human being or animals.

  式中的化合物： 其中 R1 是氨基或保护氨基、 R2是被选自以下组别的取代基取代的低级烷基：氰基、氨基甲酰基、羟基、受保护羟基、氨基、受保护氨基、低级烷氧基、低级烷硫基、低级烯硫基、可具有一个或多个合适取代基的芳基和可具有一个或多个合适取代基的杂环基、 R3 是羧基或官能修饰的羧基，以及 R4 是氢或卤素 及其药学上可接受的盐和药学上可接受的生物前体及其制备工艺。 本发明还涉及一种药物组合物，其有效成分包括与药学上可接受的、基本上无毒的载体或赋形剂一起使用的上述化合物；本发明还涉及一种治疗由病原体引起的传染病的方法，该方法包括将上述化合物施用于受感染的人或动物。
• Thiazole derivatives for preparing cephem compounds and processes for their preparation
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0049539A1

  公开（公告）日：1982-04-14

  New intermediate compounds for preparing cephem compounds, particularly of the formula and its ester and salt thereof. The intermediate compounds can be prepared by different processes, and the cephem compounds, which possess valuable pharmacological properties, can be prepared from such new intermediate compounds.

  用于制备头孢类化合物的新型中间体化合物，特别是式及其酯和盐。 这些中间体化合物可以通过不同的工艺制备，而具有重要药理特性的头孢类化合物可以从这些新型中间体化合物中制备出来。