N-(4-chloro-benzoyl)-2-hydroxy-benzamide | 21762-51-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chloro-benzoyl)-2-hydroxy-benzamide
• 英文别名: N-(p-Chlor-benzoyl)-salicylsaeureamid；N-(4-chlorobenzoyl)-2-hydroxybenzamide
• CAS: 21762-51-6
• 化学式: C₁₄H₁₀ClNO₃
• 分子量: 275.691
• InChiKey: QCYJGTMZKQHRCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(4-chloro-benzoyl)-2-hydroxy-benzamide 在 盐酸羟胺 、 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 以96%的产率得到3-(4-chlorophenyl)-5-(2-hydroxyphenyl)-1,2,4-oxadiazole
  参考文献：
  名称：

  Synthesis and study of the structure of o-hydroxyaryl-1,2,4-oxadiazoles

  摘要：

  DOI：

  10.1007/bf00767011
• 作为产物：
  描述：

  4-氯苯甲酰氯 、 水杨酰胺 在 吡啶 作用下， 反应 2.0h， 以62%的产率得到N-(4-chloro-benzoyl)-2-hydroxy-benzamide
  参考文献：
  名称：

  Synthesis of Some 2-Aryl-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-ones as Tools To Define the Essential Pharmacophoric Descriptors of a Benzodiazepine Receptor Ligand

  摘要：

  The synthesis and benzodiazepine receptor (BZR) affinity of some 1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-ones, 2-22, are reported. Compounds 2-22 are devoid of the proton donor group, which according to a BZR schematic model was one of the pharmacophoric descriptors for receptor-ligand interaction. The binding data show that 2-(2-fluorophenyl)-9-chloro-1,2,4-triazolo[1,5-c][1,3]benzoxazin-5-one (12) and some other compounds display nanomolar BZR affinity, indicating that the hydrogen donor group is not essential for the anchoring of 6,6,5-tricyclic systems to the BZR but only affects the potency of a ligand.

  DOI：

  10.1021/jm00012a020

文献信息

• Ryabukhin, Yu. I.; Faleeva, L. N.; Gorbunova, M. O., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, # 9, p. 1794 - 1800
  作者：Ryabukhin, Yu. I.、Faleeva, L. N.、Gorbunova, M. O.、Kovaleva, T. V.、Uflyand, I. E.、Sheinker, V. N.

  DOI：——

  日期：——
• Synthesis of 4-oxo-1,3-benz- and naphthoxazinium salts from o-hydroxyarylamides
  作者：O. Yu. Ryabukhina、Yu. I. Ryabukhin、B. S. Luk'yanov、G. N. Dorofeenko

  DOI：10.1007/bf00514728

  日期：1979.12
• RYABUXINA O. YU.; RYABUXIN YU. I.; LUKYANOV B. S.; DOROFEENKO G. N., XIMIYA GETEROTSIKL. SOEDIN., 1979, HO 12, 1611-1616
  作者：RYABUXINA O. YU.、 RYABUXIN YU. I.、 LUKYANOV B. S.、 DOROFEENKO G. N.

  DOI：——

  日期：——
• POLYCARBONATE RESIN COMPOSITION CONTAINING TRIAZINE COMPOUND AND MOLDED ARTICLE USING THE SAME
  申请人：Kitagawa Takashi

  公开号：US20110077331A1

  公开（公告）日：2011-03-31

  A polycarbonate resin composition comprising a compound represented by the following formula (1): wherein each of R 1a , R 1b , R 1c , R 1d and R 1e independently represents a hydrogen atom or a monovalent substituent provided that OH is excluded, at least one of the substituents represents a substituent having a Hammett's σp value of 0.3 or more, and the substituents may be combined each other to form a ring; and each of R 1g , R 1h , R 1i , R 1j , R 1k , R 1m , R 1n and R 1p independently represents a hydrogen atom or a monovalent substituent, and the substituents may be combined each other to form a ring.
• US8748520B2
  申请人：——

  公开号：US8748520B2

  公开（公告）日：2014-06-10