sodium [2-14C]pyruvate | 3275-98-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: sodium [2-14C]pyruvate
• 英文别名: sodium;2-oxo(214C)propanoate
• CAS: 3275-98-7
• 化学式: C₃H₃O₃*Na
• 分子量: 112.034
• InChiKey: DAEPDZWVDSPTHF-UOEUYCPOSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -4.67
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  57.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  sodium [2-14C]pyruvate 在 bovine serum albumine 、 enzyme preparation from Klebsiella aerogenes 、 焦磷酸硫胺素 、 magnesium sulfate 、 5,5-二甲基-1,3-环己二酮 、 1,4-哌嗪二乙磺酸 作用下， 以 水 为溶剂， 反应 3.5h， 生成 (R)-acetoin
  参考文献：
  名称：

  Crout, David H. G.; Littlechild, Jennifer; Morrey, Stephen M., Journal of the Chemical Society. Perkin transactions I, 1986, p. 105 - 108

  摘要：

  DOI：

文献信息

• Acid-Catalyzed Solvolysis of CMP-<i>N</i>-Acetyl Neuraminate:  Evidence for a Sialyl Cation with a Finite Lifetime
  作者：Benjamin A. Horenstein、Michael Bruner

  DOI：10.1021/ja961811z

  日期：1996.1.1

  An investigation of the mechanism of solvolysis of CMP-N-acetyl neuraminate (CMP-NeuAc) is presented that includes synthesis of a family of isotopically labeled CMP-NeuAc's, use of new methodology ...

  介绍了对 CMP-N-乙酰神经氨酸 (CMP-NeuAc) 溶剂分解机制的研究，包括合成同位素标记的 CMP-NeuAc 家族，使用新方法......
• Enzyme-Assisted Preparation of Isotope-Labeled 1-Deoxy-<scp>d</scp>-xylulose 5-Phosphate
  作者：Stefan Hecht、Klaus Kis、Wolfgang Eisenreich、Sabine Amslinger、Juraithip Wungsintaweekul、Stefan Herz、Felix Rohdich、Adelbert Bacher

  DOI：10.1021/jo0100300

  日期：2001.6.1

  Recombinant l-deoxy-D-xylulose 5-phosphate synthase of Bacillus subtilis was used for the preparation of isotope-labeled 1-deoxy-D-xylulose 5-phosphate using isotope-labeled glucose and/ or isotope-labeled pyruvate as starting materials. The simple one-pot methods described afford almost every conceivable isotopomer of l-deoxy-rt-xylulose 5-phosphate carrying C-13 Or C-14 from commercially available precursors with an overall yield around 50%.
• Biosynthesis of Terpenoids:  Efficient Multistep Biotransformation Procedures Affording Isotope-Labeled 2<i>C</i>-Methyl-<scp>d</scp>-erythritol 4-Phosphate Using Recombinant 2<i>C</i>-Methyl-<scp>d</scp>-erythritol 4-Phosphate Synthase
  作者：Stefan Hecht、Juraithip Wungsintaweekul、Felix Rohdich、Klaus Kis、Tanja Radykewicz、Christoph A. Schuhr、Wolfgang Eisenreich、Gerald Richter、Adelbert Bacher

  DOI：10.1021/jo015890v

  日期：2001.11.1

  This paper describes the recombinant expression of the ispC gene of Escherichia coli specifying 2C-methyl-D-erythritol 4-phosphate synthase in a modified form that can be purified efficiently by metal-chelating chromatography. The enzyme was used for the preparation of isotope-labeled 2C-methyl-D-erythritol 4-phosphate employing isotope-labeled glucose and pyruvate as starting materials. The simple one-pot methods described afford numerous isotopomers of 2C-methyl-D-erythritol 4-phosphate carrying H-3, C-13, or C-14 from commercially available precursors. The overall yield based on the respective isotope-labeled starting material is approximately 50%.
• Crout, David H. G.; Littlechild, Jennifer; Morrey, Stephen M., Journal of the Chemical Society. Perkin transactions I, 1986, p. 105 - 108
  作者：Crout, David H. G.、Littlechild, Jennifer、Morrey, Stephen M.

  DOI：——

  日期：——