3,5-dichloro-1-hydroxypyridin-4-imine | 91872-02-5

• 物质功能分类: 医药中间体 - 原料药中间体
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,5-dichloro-1-hydroxypyridin-4-imine
• 英文别名: 3,5-dichloro-4-aminopyridine 1-oxide；3,5-dichloro-4-aminopyridine N-oxide；4-amino-3,5-dichloropyridine-N-oxide；3,5-dichloro-4-aminopyridin-1-oxide；4-amino-3,5-dichloro pyridine-N-oxide；4-amino-3,5-dichloro-pyridine N-oxide；4-amino-3,5-dichloro-pyridine-N-oxide
• CAS: 91872-02-5
• 化学式: C₅H₄Cl₂N₂O
• 分子量: 179.006
• InChiKey: CEECPWRWUMQUKU-UHFFFAOYSA-N

物化性质

• 熔点：
  210 °C (decomp)
• 沸点：
  391.6±37.0 °C(Predicted)
• 密度：
  1.66±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.21
• 重原子数：
  10.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.96
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3,5-dichloro-1-hydroxypyridin-4-imine 生成 4-氨基-3,5-二氯吡啶
  参考文献：
  名称：

  TALIK, T.;TALIK, Z., PR. NAUK. AE WROCLAWIU, 1983, N 238, 97-106

  摘要：

  DOI：
• 作为产物：
  描述：

  4-氨基-3,5-二氯吡啶 在 过氧乙酸 作用下， 以 氯仿 为溶剂， 反应 48.0h， 生成 3,5-dichloro-1-hydroxypyridin-4-imine
  参考文献：
  名称：

  NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

  摘要：

  本发明涉及新型磷酸二酯酶4型（PDE4）抑制剂的化学式（1）及其类似物、互变异构体、对映异构体、二对映异构体、位置异构体、立体异构体、多晶型、药学上可接受的盐、适当的N-氧化物、药学上可接受的溶剂化合物以及含有它们的制药组合物，这些制剂在治疗过敏性和炎症性疾病方面具有用途，包括哮喘、慢性支气管炎、特应性皮炎、荨麻疹、过敏性鼻炎、过敏性结膜炎、春季结膜炎、嗜酸性肉芽肿、牛皮癣、类风湿性关节炎、脓毒性休克、溃疡性结肠炎、克罗恩病、心肌再灌注损伤和脑再灌注损伤、慢性肾小球肾炎、内毒素休克和成人呼吸窘迫综合症。

  公开号：

  US20090306082A1

文献信息

• [EN] NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES TRICYCLIQUES UTILES POUR TRAITER LES TROUBLES INFLAMMATOIRES ET ALLERGIQUES, PROCEDE DE PREPARATION DE CES COMPOSES ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：GLENMARK PHARMACEUTICALS LTD

  公开号：WO2004037805A1

  公开（公告）日：2004-05-06

  The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes.

  本发明涉及用于治疗炎症性疾病、中枢神经系统疾病和胰岛素抵抗性糖尿病的新型三环化合物。
• [EN] TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION<br/>[FR] COMPOSES TRICYCLIQUES UTILES DANS LE TRAITEMENT DE TROUBLES INFLAMMATOIRES ET ALLERGIQUES, ET PROCEDE DE PREPARATION DE CES COMPOSES
  申请人：GLENMARK PHARMACEUTICALS LTD

  公开号：WO2004069831A1

  公开（公告）日：2004-08-19

  The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastreomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention more particularly relates to novel Phosphodiesterase type 4 (PDE4) inhibitors, their analogs, their tautomers, their enantiomers, their diasteromers, their regioisomers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate oxides, their pharmaceutically acceptable solvates and the pharmaceutical compositions containing them.

  本发明涉及新颖的杂环化合物，它们的类似物，其互变异构体，其区异构体，其立体异构体，其对映异构体，其二对映异构体，其多晶型，其药用可接受盐，其适当的氧化物，其药用可接受溶剂和含有它们的药物组合物。本发明更特别涉及新颖的磷酸二酯酶4型（PDE4）抑制剂，其类似物，其互变异构体，其对映异构体，其二对映异构体，其区异构体，其立体异构体，其多晶型，其药用可接受盐，其适当的氧化物，其药用可接受溶剂和含有它们的药物组合物。
• [EN] NOVEL SOFT PDE4 INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DOUX DE PDE4
  申请人：AMAKEM NV

  公开号：WO2013021021A1

  公开（公告）日：2013-02-14

  The present invention relates to new phosphodiesterase inhibitors, more specifically soft PDE4 inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new soft PDE4 inhibitors compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including inflammatory diseases.

  本发明涉及新的磷酸二酯酶抑制剂，更具体地说是软PDE4抑制剂，包括这些抑制剂的组合物，特别是制药品，以及这些抑制剂在疾病的治疗和预防中的用途。具体来说，本发明涉及新的软PDE4抑制剂组合物，特别是包括这些抑制剂的制药品，以及这些抑制剂在疾病的治疗和预防中的用途。此外，本发明涉及治疗方法和使用上述化合物制造药物的方法，适用于多种治疗适应症，包括炎症性疾病。
• Orally active indole N-oxide PDE4 inhibitors
  作者：Christopher Hulme、Rose Mathew、Kevin Moriarty、Bruce Miller、Mercy Ramanjulu、Paul Cox、John Souness、Ken M. Page、Joanne Uhl、Jeffrey Travis、Richard Labaudiniere、Fu-chih Huang、Stevan W. Djuric

  DOI：10.1016/s0960-894x(98)00572-1

  日期：1998.11

  and in vivo evaluation of a novel potent series of phosphodiesterase type (IV) (PDE4) inhibitors. Several of the compounds presented possess low nanomolar IC50's for PDE4 inhibition and excellent in vivo activity for inhibition of TNF-alpha levels in LPS challenged mice (mouse endotoxemia model). Emesis studies (dog) and efficacy in a SCW arthritis model for the most potent PDE4 inhibitors are presented

  该交流描述了一系列新型有效的磷酸二酯酶（IV）（PDE4）抑制剂的合成以及体外和体内评估。提出的几种化合物在LPS攻击的小鼠（小鼠内毒素血症模型）中具有低纳摩尔IC50抑制PDE4和出色的体内抑制TNF-α水平的活性。介绍了最有效的PDE4抑制剂在SCW关节炎模型中的呕吐研究（狗）和功效。
• NOVEL SOFT PDE4 INHIBITORS
  申请人：Leysen Dirk

  公开号：US20140187555A1

  公开（公告）日：2014-07-03

  The present invention relates to new phosphodiesterase inhibitors, more specifically soft PDE4 inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new soft PDE4 inhibitors compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including inflammatory diseases.

  本发明涉及新的磷酸二酯酶抑制剂，更具体地是软性PDE4抑制剂，包括这种抑制剂的组合物，特别是制药用途的组合物，并且涉及使用这种抑制剂来治疗和预防疾病的用途。特别地，本发明涉及新的软性PDE4抑制剂组合物，特别是制药用途的组合物，并且涉及使用这种抑制剂来治疗和预防疾病的用途。此外，本发明还涉及治疗方法和使用所述化合物制造药物，用于多种治疗适应症，包括炎症性疾病。

表征谱图