(RS)-3-(adenin-9-yl)-1-N-tert-butyloxycarbonylpiperidine | 1271239-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: (RS)-3-(adenin-9-yl)-1-N-tert-butyloxycarbonylpiperidine
• 英文别名: tert-butyl 3-(6-amino-9H-purin-9-yl)piperidine-1-carboxylate；tert-butyl 3-(6-aminopurin-9-yl)piperidine-1-carboxylate
• CAS: 1271239-65-6
• 化学式: C₁₅H₂₂N₆O₂
• 分子量: 318.379
• InChiKey: LZUPFRQZGSECOQ-UHFFFAOYSA-N

物化性质

• 沸点：
  522.5±60.0 °C(Predicted)
• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  99.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (RS)-3-(adenin-9-yl)-1-N-tert-butyloxycarbonylpiperidine 在 三氟乙酸 作用下， 以 二氯甲烷 、 水 为溶剂， 以72%的产率得到(RS)-3-(adenin-9-yl)piperidine
  参考文献：
  名称：

  The synthesis of piperidine nucleoside analogs—a comparison of several methods to access the introduction of nucleobases

  摘要：

  This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.029
• 作为产物：
  描述：

  N-BOC-3-羟基哌啶 在 4-二甲氨基吡啶 、 caesium carbonate 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 (RS)-3-(adenin-9-yl)-1-N-tert-butyloxycarbonylpiperidine
  参考文献：
  名称：

  The synthesis of piperidine nucleoside analogs—a comparison of several methods to access the introduction of nucleobases

  摘要：

  This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.029

文献信息

• HETEROCYCLIC TYROSINE KINASE INHIBITORS
  申请人：Hopkins Brian T.

  公开号：US20130345192A1

  公开（公告）日：2013-12-26

  The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.

  本发明提供了作为Tec家族激酶抑制剂的化合物，其组成物以及使用它们的方法。
• Heterocyclic tyrosine kinase inhibitors
  申请人：Hopkins Brian T.

  公开号：US09273028B2

  公开（公告）日：2016-03-01

  The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same.

  本发明提供了一种作为Tec家族激酶抑制剂的化合物，其组成物以及使用它们的方法。
• [EN] HETEROCYCLIC TYROSINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE TYROSINE KINASE HÉTÉROCYCLIQUES
  申请人：BIOGEN IDEC INC

  公开号：WO2012058645A8

  公开（公告）日：2012-06-28
• US9273028B2
  申请人：——

  公开号：US9273028B2

  公开（公告）日：2016-03-01