N-butyl-2-phenoxyacetamide | 19039-73-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-butyl-2-phenoxyacetamide
• 英文别名: N-butyl-2-phenoxy-acetamide；N-Butyl-phenoxyacetamid
• CAS: 19039-73-7
• 化学式: C₁₂H₁₇NO₂
• mdl: MFCD00599180
• 分子量: 207.272
• InChiKey: BDZRCGPKMDTAFT-UHFFFAOYSA-N

物化性质

• 沸点：
  385.1±25.0 °C(Predicted)
• 密度：
  1.026±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯氧乙酸 在 morpholinomethyl polystyrene HL 、 PS-Ph₃P resin 、 三氯乙腈 作用下， 以 二氯甲烷 为溶剂， 生成 N-butyl-2-phenoxyacetamide
  参考文献：
  名称：

  EFFICIENT PROCEDURE FOR THE PREPARATION OF AMIDES USING POLYMER-BOUND REAGENTS

  摘要：

  An effective method for the conversion of acids into amides is presented. The two-step procedure includes the preparation of acid chloride intermediates using Pol-Ph3P and subsequent treatment of these intermediates with amines and polymer-bound base. The amides were accessible in high yields and purities without further purification.

  DOI：

  10.1081/scc-100103528

文献信息

• Electrochemical generation and reactions of acyloxytriphenylphosphonium ions
  作者：Hidenobu Ohmori、Hatsuo Maeda、Masayuki Kikuoka、Toshihide Maki、Masaichiro Masui

  DOI：10.1016/s0040-4020(01)87066-6

  日期：1991.1

  undivided cell, of Ph3P in the presence of a carboxylic acid in CH2Cl2 containing 2,6-lutidinium perchlorate as the supporting electrolyte was shown to generate the corresponding acyloxyphosphonium ion, Ph3P+-OCOR, which was converted in situ to esters, amides, and β-lactams under mild conditions.

  结果表明，在羧酸存在下的CH 2 Cl 2中，含高氯酸2,6-lut啶鎓作为辅助电解质的PH 3 P在不分隔的电池中恒流电解会生成相应的酰氧基phosph离子Ph 3 P + -OCOR，在温和条件下原位转化为酯，酰胺和β-内酰胺。
• Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same
  申请人：Davis T. Jeffery

  公开号：US20050009921A1

  公开（公告）日：2005-01-13

  A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chloride ion across the lipid bilayer.

  含有至少两个芳香环的化合物，这些芳香环以共价键结合在一起，每个芳香环至少含有一个氧乙酰胺基侧链，该化合物能够在脂质双分子层上形成氯离子通道，并在脂质双分子层上运输氯离子。
• Inhibitors of protein isoprenyl transferases
  申请人：Abbott Laboratories

  公开号：US06277871B1

  公开（公告）日：2001-08-21

  The present invention relates to novel compounds of Formula I which are useful in inhibiting protein isoprenyl transferases and the farnesylation or geranylgeranylation of the oncogene protein Ras and other related small g-proteins, and compositions containing such compounds and methods of using such compounds.

  本发明涉及一种新的I式化合物，可用于抑制蛋白异戊烯基转移酶和癌基因蛋白Ras及其他相关小G蛋白的法尼酰化或戊二烯基化，以及含有此类化合物的组合物和使用此类化合物的方法。
• Ion Channel Formation from a Calix[4]arene Amide That Binds HCl
  作者：Vladimir Sidorov、Frank W. Kotch、Galya Abdrakhmanova、Robert Mizani、James C. Fettinger、Jeffery T. Davis

  DOI：10.1021/ja012338e

  日期：2002.3.1

  The ion transport activity of calix[4]arene tetrabutylamide 1,3-alt 2 was studied in liposomes, planar lipid bilayers, and HEK-293 cells. These experiments, when considered together with H-1 NMR and X-ray crystallography data, indicate that calix[4]arene tetrabutylamide 2 (1) forms ion channels in bilayer membranes, (2) mediates ion transport across cell membranes at positive holding potential, (3) alters the pH inside liposomes experiencing a Cl- gradient, and (4) shows a significant Cl-/SO42- transport selectivity. An analogue, calix[4]arene tetramethylamide 1, self-assembles in the presence of HCl to generate solid-state structures with chloride-filled and water-filled channels. Structure-activity studies indicate that the hydrophobicity, amide substitution, and macrocyclic framework of the calixarene are essential for HCl binding and transport. Calix[4]arene tetrabutylamide 2 is a rare example of an anion-dependent, synthetic ion channel.
• US6277871B1
  申请人：——

  公开号：US6277871B1

  公开（公告）日：2001-08-21