N-(2-phenylethyl)phenoxyacetamide | 18861-16-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-(2-phenylethyl)phenoxyacetamide
• 英文别名: 2-phenoxy-N-(2-phenylethyl)acetamide
• CAS: 18861-16-0
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: GDCVHJQWGCHXEY-UHFFFAOYSA-N

物化性质

• 沸点：
  477.8±38.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  苯氧乙酸 在 morpholinomethyl polystyrene HL 、 PS-Ph₃P resin 、 三氯乙腈 作用下， 以 二氯甲烷 为溶剂， 生成 N-(2-phenylethyl)phenoxyacetamide
  参考文献：
  名称：

  EFFICIENT PROCEDURE FOR THE PREPARATION OF AMIDES USING POLYMER-BOUND REAGENTS

  摘要：

  An effective method for the conversion of acids into amides is presented. The two-step procedure includes the preparation of acid chloride intermediates using Pol-Ph3P and subsequent treatment of these intermediates with amines and polymer-bound base. The amides were accessible in high yields and purities without further purification.

  DOI：

  10.1081/scc-100103528

文献信息

• Electrochemical generation and reactions of acyloxytriphenylphosphonium ions
  作者：Hidenobu Ohmori、Hatsuo Maeda、Masayuki Kikuoka、Toshihide Maki、Masaichiro Masui

  DOI：10.1016/s0040-4020(01)87066-6

  日期：1991.1

  undivided cell, of Ph3P in the presence of a carboxylic acid in CH2Cl2 containing 2,6-lutidinium perchlorate as the supporting electrolyte was shown to generate the corresponding acyloxyphosphonium ion, Ph3P+-OCOR, which was converted in situ to esters, amides, and β-lactams under mild conditions.

  结果表明，在羧酸存在下的CH 2 Cl 2中，含高氯酸2,6-lut啶鎓作为辅助电解质的PH 3 P在不分隔的电池中恒流电解会生成相应的酰氧基phosph离子Ph 3 P + -OCOR，在温和条件下原位转化为酯，酰胺和β-内酰胺。
• Electron-rich Triarylbismuthines as Selective Condensation Reagent under Neutral Conditions. Condensation of Aliphatic Carboxylic Acids with Amines and Alcohols
  作者：Takuji Ogawa、Tetsuya Hikasa、Tohru Ikegami、Noboru Ono、Hitomi Suzuki

  DOI：10.1246/cl.1993.815

  日期：1993.5

  On heating with amines or alcohols in the presence of tris(2-methoxy phenyl)- or tris(2,6-dimethoxyphenyl)bismuthine, carboxylic acids bearing α-hydrogen are readily converted into the corresponding amides or esters in good yields while those without α-hydrogen remain intact.

  在三(2-甲氧基苯基)-或三(2,6-二甲氧基苯基)铋碱存在下与胺或醇加热时，带有α-氢的羧酸很容易以良好的产率转化为相应的酰胺或酯，而不含α-氢的羧酸很容易转化为相应的酰胺或酯。 α-氢保持完整。
• Ogawa, Takuji; Hikasa, Tetsuya; Ikegami, Tohru, Journal of the Chemical Society. Perkin transactions I, 1994, # 23, p. 3473 - 3478
  作者：Ogawa, Takuji、Hikasa, Tetsuya、Ikegami, Tohru、Ono, Noboru、Suzuki, Hitomi

  DOI：——

  日期：——
• Irreversible Enzyme Inhibitors. CVII.¹ Proteolytic Enzymes. II.² Bulk Tolerance within Chymotrypsin-Inhibitor Complexes
  作者：B. R. Baker、Jeffrey A. Hurlbut

  DOI：10.1021/jm00318a031

  日期：1967.11
• BIR DOMAIN BINDING COMPOUNDS
  申请人：Jarvis Scott

  公开号：US20100292269A1

  公开（公告）日：2010-11-18

  The present invention is directed towards an isomer, an enantiomer, a diastereoisomer, or a tautomer of a pyrrolidine compound represented by Formula I: in which the substituents R 1 , R 1a , R 2 , R 2a , R 3 , A and Q are defined herein; or a prodrug, or a salt thereof, and which bind to IAP BIR domains. In particular, the compounds are useful in treating proliferative disorders such as cancer