(2R,4S,5R)-(-)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione | 57573-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,4S,5R)-(-)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione
• 英文别名: (4S)-2-chloro-3,4r-dimethyl-5c-phenyl-[1,3,2]oxazaphospholidine 2c-sulfide；(2S,4R,5S)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2oxazaphospholidine-2-thione；N,O-(R)-chlorothiophosphoryl-(-)-ephedrine；(2R,4S,5R)-2-chloro-3,4-dimethyl-5-phenyl-2-sulfanylidene-1,3,2λ5-oxazaphospholidine
• CAS: 57573-32-7
• 化学式: C₁₀H₁₃ClNOPS
• 分子量: 261.712
• InChiKey: AYEYHZBPPMGEKL-BXGCZWRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  44.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2R,4S,5R)-(-)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione 在 盐酸 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Cooper,D.B. et al., Journal of the Chemical Society. Perkin transactions I, 1977, p. 1969 - 1980

  摘要：

  DOI：
• 作为产物：
  描述：

  盐酸麻黄碱 在 三乙胺 、 三氯氧磷 作用下， 以 苯 为溶剂， 生成 (2R,4S,5R)-(-)-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazaphospholidine-2-thione
  参考文献：
  名称：

  Cooper,D.B. et al., Journal of the Chemical Society. Perkin transactions I, 1977, p. 1969 - 1980

  摘要：

  DOI：

文献信息

• Synthetic approaches to the alkaloids of the ancistrocladaceae: (–)-O-methylancistrocladine and (+)-O-methylhamatine
  作者：Mark A. Rizzacasa、Melvyn V. Sargent

  DOI：10.1039/c39900000894

  日期：——

  An asymmetric total synthesis of the naphthylisoquinoline alkaloid (–)-O-methylancistrocladine (2) is described; the synthetic method also provides routes to the atropisomer O-methylhamatine (4) and the enantiomers of these alkaloids.

  记载了萘基异喹啉生物碱（-）- O-甲基顺二十二烷（2）的不对称全合成。合成方法还提供了到达阻转异构体O-甲基哈马汀（4）和这些生物碱的对映异构体的途径。
• Novel methods for ester detoxication
  申请人：Cashman John

  公开号：US20070286846A1

  公开（公告）日：2007-12-13

  This invention relates to a method for detoxication of inorganic or organic esters including OP nerve agents, cocaine, and respective analogs. More specifically, this invention pertains to the treatment of potentially neurotoxic esters or other ester groups by elaborating a more effective hydrolytic enzyme for therapeutic application. The structures of the synthesized OP analogs are provided. This invention also provides a diagnostic method and an Array Biosensor for detecting OP agents in biological and environmental samples.

  这项发明涉及一种用于解毒无机或有机酯类化合物，包括OP神经毒剂、可卡因及其类似物的方法。更具体地说，这项发明涉及通过开发一种更有效的水解酶用于治疗应激性神经毒性酯类化合物或其他酯基团。提供了合成的OP类似物的结构。这项发明还提供了一种诊断方法和用于检测生物和环境样本中的OP类毒剂的阵列生物传感器。
• SYNTHESIS AND REACTIVITY OF DENDRIMERS BASed ON PHOSPHORYL (P=O) GROUPS
  作者：Marie-Laure Lartigue、Anne-Marie Caminade、Jean Pierre Majoral

  DOI：10.1080/10426509708044195

  日期：1997.4.1

  The synthesis of phosphoryl-based dendrimers is described, using the reiteration of a two-steps process which gives alternatively aldehyde and P(O)Cl-2 end groups. The synthesis has been carried out up to the third generation, to give a compound which bears 24 chlorine atoms on the surface. Preliminary experiments on the first generation of the dendrimer possessing either 6 CHO or 6 Cl groups show that these compounds display a versatile reactivity. For instance, alpha, beta-unsaturated esters, crown ethers, chiral phosphine sulfides or diallylamine are grafted on the surface, and the resulting dendrimers are isolated in good to nearly quantitative yields.
• Aagaard, Olav M.; Janssen, René A. J.; De Waal, Bas F. M., Journal of the American Chemical Society, 1990, vol. 112, # 3, p. 938 - 944
  作者：Aagaard, Olav M.、Janssen, René A. J.、De Waal, Bas F. M.、Buck, Henk M.

  DOI：——

  日期：——
• Janssen, R. A. J.; Aagaard, O. M.; Buck, H. M., Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 51/52, p. 758
  作者：Janssen, R. A. J.、Aagaard, O. M.、Buck, H. M.

  DOI：——

  日期：——