potassium pseudomonate | 870771-36-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: potassium pseudomonate
• 英文别名: potassium;9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate
• CAS: 870771-36-1
• 化学式: C₂₆H₄₃O₉*K
• 分子量: 538.72
• InChiKey: SIPPQQZQMKRGGX-JATHGWPISA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.74
• 重原子数：
  36
• 可旋转键数：
  17
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  potassium pseudomonate 在 calcium chloride 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 calcium mupirocin
  参考文献：
  名称：

  Process for preparation of amorphous form of a drug

  摘要：

  提供了一种制备活性药物成分非晶态形式的过程。

  公开号：

  US20050272768A1
• 作为产物：
  描述：

  莫匹罗星 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 potassium pseudomonate
  参考文献：
  名称：

  Process for preparation of amorphous form of a drug

  摘要：

  提供了一种制备活性药物成分非晶态形式的过程。

  公开号：

  US20050272768A1

文献信息

• Processes for preparing crystalline and amorphous mupirocin calcium
  申请人：——

  公开号：US20040024052A1

  公开（公告）日：2004-02-05

  Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its prepration by solvent removal, lyophilization and precipitation with use of an anti-solvent. Pharmaceutical compositions of amorphous form, and methods of using them to treat infections are also provided. Also provided are combined processes for preparing mupirocin calcium dihydrate and amorphous, by producing amorphous form first, followed by conversion of amorphous form into the dihydrate through crystallization from an aqueous solution. Also provided are processes for removing the water of crystallization of the dihydrate to obtain muprirocin calcium anhydrate.

  提供了一种使用有机羧酸盐在两相体系中从假单胞菌酸制备盐酸倍氯米松二水合物的工艺。提供了高纯度无定形盐酸倍氯米松钙的组合，并通过溶剂去除、冻干和使用抗溶剂沉淀的工艺来制备它。还提供了无定形形式的制药组合物以及使用它们来治疗感染的方法。还提供了联合工艺，通过首先生产无定形形式，然后通过从水溶液中结晶将无定形形式转化为二水合物。还提供了去除二水合物结晶水以获得盐酸倍氯米松无水物的工艺。
• EP1455769A4
  申请人：——

  公开号：EP1455769A4

  公开（公告）日：2004-09-22
• PROCESSES FOR PREPARING CRYSTALLINE AND AMORPHOUS MUPIROCIN CALCIUM
  申请人：BIOGAL GYOGYSZERGYAR RT.

  公开号：EP1455769A2

  公开（公告）日：2004-09-15
• US7737177B2
  申请人：——

  公开号：US7737177B2

  公开（公告）日：2010-06-15
• [EN] PROCESSES FOR PREPARING CRYSTALLINE AND AMORPHOUS MUPIROCIN CALCIUM<br/>[FR] PROCEDES DE PREPARATION DE MUPIROCINE CALCIQUE CRISTALLINE ET AMORPHE
  申请人：BIOGAL GYOGYSZERGYAR

  公开号：WO2003065975A2

  公开（公告）日：2003-08-14

  Processes are provided for preparing mupirocin calcium dihydrate from pseudomonic acid in a two phase system by using an organic carboxylate. A highly pure composition of amorphous mupirocin calcium is provided, and processes for its preparation by solvent removal, lyophilization and precipitation with use of anti-solvent. Pharmaceutical compositions of amorphous form, and methods of using them to treat infections are also provided. Also provided are combined processes for preparing mupirocin clacium dihydrate and amorphous, by producing amorphous form first, followed by conversion of amorphous form into the dihydrate through crystallization from an aqueous solution. Also provided are processes for removing the water of crystallization of the dihydrate to obtain mupirocin calcium anhydrate.