(R,S)-1,2-dimethyl-3-pyrrolidone | 89531-03-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (R,S)-1,2-dimethyl-3-pyrrolidone
• 英文别名: 1,2-dimethyl-3-oxo pyrrolidine；1,2-dimethyl-pyrrolidin-3-one；1,2-Dimethyl-pyrrolidin-3-on；1,2-Dimethyl-pyrrolidon-(3)；1,2-Dimethyl-pyrrolid-3-on；1,2-Dimethyl-3-pyrrolidon；1,2-Dimethylpyrrolidin-3-one
• CAS: 89531-03-3
• 化学式: C₆H₁₁NO
• 分子量: 113.159
• InChiKey: VEUYRZJQDCCKKP-UHFFFAOYSA-N

物化性质

• 沸点：
  55 °C(Press: 22 Torr)
• 密度：
  0.973±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R,S)-1,2-dimethyl-3-pyrrolidone 在 palladium on activated charcoal 氢气 、 叔丁基锂 作用下， 以 乙醚 、 二氯甲烷 、 正戊烷 为溶剂， 反应 4.0h， 生成 (2RS,3SR)-1,2-dimethyl-3-hydroxy-3-(4-hydroxyphenyl)-pyrrolidine
  参考文献：
  名称：

  Synthesis and pharmacological evaluation of new N-methyl-arylpyrrolidinols with analgesic activity

  摘要：

  In the present paper, we report on the synthesis and antinociceptive activity of a new series of N-methyl-arylpyrrolidinols that we designed for a rational structure-activity relationship (SAR) study. The antinociceptive properties were investigated in vivo by the hot plate and formalin tests in mice and control on the locomotory activity was also monitored by the rota rod test. With this aim, the evaluation of the lipophilicity of all compounds was performed by the Daylight computational method in order to better understand the SAR. Interesting properties were proven for the compounds of the entire series.

  DOI：

  10.1016/s0014-827x(03)00152-6

文献信息

• [EN] PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS<br/>[FR] COMPOSÉS PYRIMIDINYL-PYRIDYLOXY-NAPHTYLE ET PROCÉDÉS DE TRAITEMENT DE MALADIES ET DE TROUBLES LIÉS À IRE1
  申请人：GENENTECH INC

  公开号：WO2018166528A1

  公开（公告）日：2018-09-20

  Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula (I) or (I') structure : or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula (I) or (I') compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

  本文描述了具有肌醇需要酶1（IRE1）调节活性或功能的嘧啶基-吡啶氧基-萘基化合物，其具有公式（I）或（I'）结构：或其立体异构体，互变异构体或药学上可接受的盐，并具有所述的取代基和结构特征。还描述了包括公式（I）或（I'）化合物的制药组合物和药物，以及使用这种IRE1调节剂的方法，单独或与其他治疗剂联合治疗介导或依赖于雌激素受体的疾病或病况。
• [EN] RELEASABLE ANTIBODY CONJUGATES<br/>[FR] CONJUGUÉS D'ANTICORPS LIBÉRABLES
  申请人：QUIAPEG PHARMACEUTICALS AB

  公开号：WO2019171358A1

  公开（公告）日：2019-09-12

  This document provides compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein D is a residue of a cytotoxic or chemotherapeutic compound, which undergoes hydrolysis under physiological conditions to release the cytotoxic or chemotherapeutic compound and which are useful in the treatment of cancer and other diseases.

  本文件提供了化合物的公式(I)，或其药用盐，其中D是细胞毒性或化疗化合物的残基，该残基在生理条件下水解释放出细胞毒性或化疗化合物，并且在癌症和其他疾病的治疗中是有用的。
• Thermally conductive polyimide film composites having high thermal conductivity useful in an electronic device
  申请人：E.I. du Pont de Nemours and Company

  公开号：EP1672009A1

  公开（公告）日：2006-06-21

  In electronic devices, heat removal is an important consideration of any device designer. Thermally conductive, high-temperature polyimide composites are disclosed herein which are generally useful as a dielectric layer in an electronic device, or a precursor metal-laminate, where the dielectric is layered on one side (or on both sides) with a metal. The polyimide composites of the present invention contain dispersed therein thermally conductive filler particles at a weight percent between 40 and 85 % weight percent. These film composites have good dielectric strength, good thermal conductivity, and optionally good adhesivity.

  在电子设备中，散热是任何设备设计者都要考虑的重要问题。本发明公开了导热性高温聚酰亚胺复合材料，它通常可用作电子设备中的电介质层或金属层压板的前驱体，其中电介质在一侧（或两侧）与金属分层。本发明的聚酰亚胺复合材料中分散有重量百分比在 40% 至 85% 之间的导热填料颗粒。这些薄膜复合材料具有良好的介电强度、导热性和可选的粘合性。
• Thermally conductive polyimide film composites having high mechanical elongation useful as a heat conducting portion of an electronic device
  申请人：E.I. du Pont de Nemours and Company

  公开号：EP1672008A1

  公开（公告）日：2006-06-21

  In electronic devices, heat removal is an important consideration of any device designer. Thermally conductive, high-temperature polyimide composites are disclosed herein which are generally useful as a dielectric layer in an electronic device, or a precursor metal-laminate, where the dielectric is layered on one side (or on both sides) with a metal. The polyimide composites of the present invention contain dispersed therein thermally conductive filler particles where the polyimide is derived in part from a polysiloxane diamine. These film composites have good mechanical elongation, good dielectric strength, and optionally good adhesivity (i.e. laminatability) (i.e. laminatability) and low modulus, while also possessing good thermal conductivity.

  在电子设备中，散热是任何设备设计者都要考虑的重要问题。本发明公开了导热性高温聚酰亚胺复合材料，它通常可用作电子设备中的电介质层或先驱金属层压板，其中电介质的一面（或两面）与金属分层。本发明的聚酰亚胺复合材料含有分散在其中的导热填料颗粒，其中的聚酰亚胺部分来自聚硅氧烷二胺。这些薄膜复合材料具有良好的机械伸长率、良好的介电强度、可选的良好粘合性（即层压性）和低模量，同时还具有良好的导热性。
• CARBON NANOTUBE DISPERSION, SLURRY FOR SECONDARY BATTERY ELECTRODE, METHOD FOR PRODUCING SLURRY FOR SECONDARY BATTERY ELECTRODE, SECONDARY BATTERY ELECTRODE, AND SECONDARY BATTERY
  申请人：Zeon Corporation

  公开号：EP3770204A1

  公开（公告）日：2021-01-27

  Disclosed is a carbon nanotube dispersion liquid containing carbon nanotubes, a binder, and a dispersion medium. The binder includes a polymer (A) containing an aromatic vinyl monomer unit and a linear alkylene structural unit having a carbon number of at least 4. The proportion of the binder in the carbon nanotube dispersion liquid is 30 mass% or less, and the viscosity change rate of the carbon nanotube dispersion liquid as measured under predetermined conditions before and after leaving the carbon nanotube dispersion liquid for 1 week is 50 % or more and 300 % or less.

  本发明公开了一种含有碳纳米管、粘合剂和分散介质的碳纳米管分散液。粘合剂包括聚合物 (A)，其中含有芳香乙烯基单体单元和碳原子数至少为 4 的线性亚烷基结构单元。粘合剂在碳纳米管分散液中的比例为 30% 或更低，在预定条件下测量碳纳米管分散液在放置 1 周之前和之后的粘度变化率分别为 50% 或更高和 300% 或更低。