4-(2-biphenyl)phenol | 115237-86-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-biphenyl)phenol
• 英文别名: 4-(2-biphenylyl)phenol；4-hydroxy-1,1':2',1”-terphenyl；4-(Biphenylyl-(2))-phenol；o-Terphenyl-4-ol；4-Hydroxy-o-terphenyl；p-Hydroxyterphenyl；4-(2-phenylphenyl)phenol
• CAS: 115237-86-0
• 化学式: C₁₈H₁₄O
• 分子量: 246.309
• InChiKey: UDAYUFIOVWRZJI-UHFFFAOYSA-N

物化性质

• 熔点：
  109-110 °C
• 沸点：
  379.6±11.0 °C(Predicted)
• 密度：
  1.127±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(2-biphenyl)phenol 在 偶氮二异丁腈 、 三氟乙酸 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 以80.3%的产率得到2-hydroxytriphenylene
  参考文献：
  名称：

  一种三亚苯衍生物的制备方法

  摘要：

  本发明涉及有机化学领域，特别是涉及一种三亚苯衍生物的制备方法。本发明提供一种三亚苯衍生物的制备方法，包括：将式4化合物在酸、引发剂和氧化剂存在的条件下进行关环反应，以提供式5化合物。本发明所提供的三亚苯衍生物的制备方法，通过使用酸和氧化剂进行芳基化反应，反应中所产生的副反应少、反应整体转化率高、且原料经济实惠，另外，整个反应路线整体上也具有很高的反应收率高，工业化生产操作方便，具有良好的产业化前景。

  公开号：

  CN112574010B
• 作为产物：
  描述：

  4,4-二甲氧基-2,5-环己二烯-1-酮 在 铜 、 溶剂黄146 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 4-(2-biphenyl)phenol
  参考文献：
  名称：

  Intramolecular anodic carbon-carbon bond-forming reactions of oxidized phenol intermediates leading to spirodienones. Structural effects on reactivity and evidence for a phenoxonium ion intermediate

  摘要：

  Anodic oxidation of 4-phenylphenol in methanol leads to 4-methoxy-4-phenylcyclohexa-2,5-dienones whereas anodic oxidation of 4-(2-alkenylphenyl)-phenols leads to spirocyclic 2,5-cyclohexadienones in competition with methanol addition to the 4-position. Using 4-phenylphenol and (4-(2-propenylphenyl)phenol as model systems, the optimum conditions for solvent addition versus carbon-carbon bond formation have been studied. The yield of the anodic cyclization reaction shows a dramatic dependence on olefin structure. Whereas 4-(2-propenylphenyl)phenol gives the spirocyclic 2,5-cyclohexadienone in high yield, 4-(2-vinylphenyl)phenol affords the analogous product in only 16 % yield. This low yield of intramolecular carbon-carbon bond-forming reactions can be markedly improved if the vinyl substituent is forced closer to the 4-position of the phenol by the buttressing effect of a o-methyl group. Coloumetric studies as well as the oxidation chemistry of a (4-hydroxyphenyl)(2-propenylaryl)methane derivative support the involvement of a phenoxonium ion as the intermediate in these carbon-carbon bond-forming reactions. Finally, non-oxidative generation of a phenoxonium ion by reaction of 4-hydroxy-4-(2-propenylphenyl)2,5-cyclohexadieneone with methanesulfonyl chloride/triethylamine leads to spirodienones related to those isolated in the anodic oxidation chemistry. Although a slightly acidic media is critical for obtaining good yields of spirodienones for the propenyl system, anodic oxidation of the trimethylsilyl derivatives of the phenol allows this reaction to be performed in neutral or slightly basic media.

  DOI：

  10.1021/jo00064a017

文献信息

• FLAME-RETARDANT POLYESTER FIBER AND METHOD FOR PRODUCING SAME
  申请人：DAIHACHI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1857586A1

  公开（公告）日：2007-11-21

  A preparation process of flame-retardant polyester fibers, comprising the steps of: impregnating polyester fibers with a flame retardancy giving liquid containing a phosphorus compound as a flame-retarder represented by the formula (I): wherein Ar represents a phenyl or naphthyl group which may be substituted by C1-4 alkyl groups, and n represents an integer 1 to 3; thermally treating the polyester fibers under normal or increased pressure after or at the same time as the impregnation treatment; and thereby giving flame retardancy to the polyester fibers.

  一种阻燃聚酯纤维的制备工艺，包括以下步骤：用含有磷化合物的阻燃剂液体浸渍聚酯纤维，该阻燃剂由式（I）表示： 其中 Ar 代表可被 C1-4 烷基取代的苯基或萘基，n 代表 1 至 3 的整数；在浸渍处理之后或同时，在常压或增压下对聚酯纤维进行热处理；从而使聚酯纤维具有阻燃性。
• ERβ Ligands. Part 1: The discovery of ERβ selective ligands which embrace the 4-hydroxy-biphenyl template
  作者：R Edsall

  DOI：10.1016/s0968-0896(03)00303-1

  日期：2003.8.5

  The synthesis and structure-activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERP selectivity on the order of 20-70-fold. (C) 2003 Elsevier Ltd. All rights reserved.
• THE CHEMISTRY OF o-TERPHENYL. III. SULFONIC ACIDS
  作者：C. F. H. ALLEN、D. M. BURNESS

  DOI：10.1021/jo01153a023

  日期：1949.1
• Spiro-annulated cyclohexa-2,5-dienones via electrooxidation of p-aryl phenols a novel mode of anodic carbon-carbon bond formation
  作者：Gary W. Morrow、John S. Swenton

  DOI：10.1016/s0040-4039(00)96750-9

  日期：1987.1
• EP1408986A4
  申请人：——

  公开号：EP1408986A4

  公开（公告）日：2006-01-11