2,6-dichloro-N-methoxy-N-methylnicotinamide | 873936-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,6-dichloro-N-methoxy-N-methylnicotinamide
• 英文别名: Ro 4808591；2,6-Dichloro-N-methoxy-N-methylpyridine-3-carboxamide
• CAS: 873936-98-2
• 化学式: C₈H₈Cl₂N₂O₂
• 分子量: 235.07
• InChiKey: KBSJBBWIKLORJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,6-dichloro-N-methoxy-N-methylnicotinamide 在 甲醇 、 sodium tetrahydroborate 、 N-溴代丁二酰亚胺(NBS) 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 、 二氯甲烷 为溶剂， 反应 6.0h， 生成 3-(1-bromo-ethyl)-2,6-dichloro-pyridine
  参考文献：
  名称：

  Compounds and Their Use for Treatment of Amyloid Beta-Related Diseases

  摘要：

  本发明涉及式(I)的新化合物及其药用盐，包括含有该化合物的药物组合物，制备该化合物的方法，以及它们作为治疗和/或预防Aβ相关疾病的药物的用途。

  公开号：

  US20120122843A1
• 作为产物：
  描述：

  2,6-二氯烟酸 在 氯化亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 2,6-dichloro-N-methoxy-N-methylnicotinamide
  参考文献：
  名称：

  Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer

  摘要：

  DOI：

  10.1021/acs.jmedchem.1c00890

文献信息

• [EN] NOVEL TRIAZOLE DERIVATIVES AND THEIR USE AS FUNGICIDES<br/>[FR] NOUVEAUX DÉRIVÉS DE TRIAZOLE ET LEUR UTILISATION EN TANT QUE FONGICIDES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2018054829A1

  公开（公告）日：2018-03-29

  The present invention relates to novel triazole derivatives of formula (I), wherein A, R2, R4, m, and Y are defined as in the claims, to compositions comprising these compounds, to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials, and to intermediates useful for preparing these compounds.

  本发明涉及公式（I）的新型三唑衍生物，其中A、R2、R4、m和Y如权利要求中所定义，以及包含这些化合物的组合物，其用作生物活性化合物，特别用于控制作物保护中的有害微生物和材料保护中，以及用于制备这些化合物的中间体。
• [EN] NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS<br/>[FR] NOUVEAUX COMPOSÉS INDOLE ET INDAZOLE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE LA PHOSPHODIESTÉRASE
  申请人：GRUENENTHAL GMBH

  公开号：WO2018234353A1

  公开（公告）日：2018-12-27

  The invention relates to novel indole and indazole compounds characterized in that the compound has general formula (I), in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

  该发明涉及新型吲哚和吲唑化合物，其特征在于该化合物具有通式（I），其中化学基团、取代基、变量和指数如描述中所定义，并且用作药物，特别是用作治疗可以通过抑制PDE4酶来治疗的疾病和病症的药物。
• 2,6-Diaminopyridine derivatives
  申请人：Bartkovitz Joseph David

  公开号：US20060014708A1

  公开（公告）日：2006-01-19

  Novel 2,6-diaminopyridine derivatives of formula wherein R 1 and R 2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

  本发明涉及一种新型2,6-二氨基吡啶衍生物，其化学式如下，其中R1和R2的定义如下，这些化合物能够抑制细胞周期依赖的激酶。这些化合物及其药学上可接受的盐和酯具有抗增殖活性，并可用于治疗或控制癌症，尤其是固体肿瘤。本发明还涉及含有这些化合物的药物组合物以及治疗或控制癌症的方法，尤其是治疗或控制乳腺、肺、结肠和前列腺肿瘤。还公开了在制备这些新型2,6-二氨基吡啶衍生物中有用的中间体。
• 2,6-diaminopyridine derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US07423051B2

  公开（公告）日：2008-09-09

  Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment or control of breast, lung, colon and prostate tumors. Also disclosed are intermediates useful in the preparation of these novel 2,6-diaminopyridine derivatives.

  本发明揭示了公式中R1和R2如下所定义的新颖2,6-二氨基吡啶衍生物。这些化合物抑制细胞周期依赖性激酶。这些化合物及其药学上可接受的盐和酯具有抗增殖活性，并可用于治疗或控制癌症，尤其是实体肿瘤。本发明还涉及含有这些化合物的制药组合物以及治疗或控制癌症的方法，尤其是乳腺癌、肺癌、结肠癌和前列腺肿瘤的治疗或控制。还揭示了在制备这些新颖的2,6-二氨基吡啶衍生物中有用的中间体。
• Ring-fused compound
  申请人：Nagai Keita

  公开号：US08987473B2

  公开（公告）日：2015-03-24

  The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represented by Formula (I) below. [in the formula, R1 is -Q1-A1 and the like; is a double bond or a single bond; when is a double bond, W1 is a nitrogen atom or a group represented by the general formula: ═C(Ra)—, and W2 is a nitrogen atom or a group represented by the general formula: ═C(Rb)—; when is a single bond, W1 is a group represented by the general formula: —C(Raa)(Rab)— or a group represented by the general formula: —(C═O)—, and W2 is a group represented by the general formula: —C(Rba)(Rbb)—, a group represented by the general formula: —(C═O)— or a group represented by the general formula: —N(Rbc)—; W3, W4 and W5 are each independently a nitrogen atom or a methine group and the like that may have a substituent; X is a single bond, an oxygen atom and the like; Y is a single bond or (CRYiRYi′)n; and Z is a hydroxyl group or COOR2 and the like.

  本发明涉及一种具有URAT1抑制作用的化合物，以及一种URAT1抑制剂、降低血尿酸水平的药剂和包括该化合物的制药组合物。更具体地说，本发明涉及下式（I）所表示的化合物。[在该式中，R1是-Q1-A1等；是双键或单键；当为双键时，W1是一个氮原子或由一般式表示的基团：═C（Ra）-，W2是一个氮原子或由一般式表示的基团：═C（Rb）-；当为单键时，W1是由一般式表示的基团：-C（Raa）（Rab）-或由一般式表示的基团：-（C═O）-，W2是由一般式表示的基团：-C（Rba）（Rbb）-，由一般式表示的基团：-（C═O）-或由一般式表示的基团：-N（Rbc）-；W3、W4和W5各自独立地是氮原子或可能具有取代基的甲烷基等；X是单键、氧原子等；Y是单键或（CRYiRYi'）n；Z是羟基或COOR2等。]