4-(2-Oxo-2-phenyl-1-chloroethylidene)-2,2,5,5-tetramethylimidazolidine-1-oxyl | 84359-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2-Oxo-2-phenyl-1-chloroethylidene)-2,2,5,5-tetramethylimidazolidine-1-oxyl
• CAS: 84359-72-8
• 化学式: C₁₅H₁₈ClN₂O₂
• 分子量: 293.773
• InChiKey: LYDUZYGLDPMXEO-ACCUITESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  33.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-Oxo-2-phenyl-1-chloroethylidene)-2,2,5,5-tetramethylimidazolidine-1-oxyl 在 sodium azide 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以95%的产率得到4-(1-imino-2-oxo-2-phenylethyl)-2,2,5,5-tetramethyl-3-imidazoline-1-oxyl
  参考文献：
  名称：

  摘要：

  The reaction of 4-(2R-1-chloro-2-oxoethylidene) -substituted imidazolidine-1-oxyl with sodium azide gives monoimines of alpha -diketones, derivatives of 3-imidazoline nitroxides. Reactions of these products with nitrogen binucleophiles were used to prepare various heterocyclic compounds containing an imidazoline nitroxide moiety.

  DOI：

  10.1023/a:1011319528481
• 作为产物：
  描述：

  1-hydroxy-4-phenylacylidine-2,2,5,5-tetramethylimidazolidine 在 manganese(IV) oxide 、 N-氯代丁二酰亚胺 作用下， 生成 4-(2-Oxo-2-phenyl-1-chloroethylidene)-2,2,5,5-tetramethylimidazolidine-1-oxyl
  参考文献：
  名称：

  Stable vinylnitroxyl radicals, pyrroline derivatives

  摘要：

  DOI：

  10.1007/bf02499074

文献信息

• Nucleophilic Substitution of Chloro-Substituted Enaminones that are Derivatives of Imidazolidine Nitroxides− The Catalytic Effect of the Cyanide Ion
  作者：Galina I. Roshchupkina、Tatyana V. Rybalova、Yury V. Gatilov、Vladimir A. Reznikov

  DOI：10.1002/ejoc.200200722

  日期：2003.9

  The cyanide ion is a catalyst for reactions of nucleophiles with chloro-substituted enaminones derived from imidazolidine nitroxides, which result in the formation of formal nucleophilic substitution products. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

  氰化物离子是亲核试剂与衍生自咪唑烷氮氧化物的氯代烯胺酮反应的催化剂，从而形成正式的亲核取代产物。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)
• Reactions of chloro-substituted enaminoketones,viz., derivatives of imidazolidine nitroxides, with sodium cyanide
  作者：V. A. Reznikov、I. Yu. Bagryanskaya、Yu. V. Gatilov

  DOI：10.1007/bf02494716

  日期：2000.5

  The reactions of chloro-substituted enaminoketones,viz., derivatives of imidazolidine nitroxides, with sodium cyanide afford the corresponding nitriles. The reactions proceed through formation of epoxides. The structure of one of these epoxides was confirmed by X-ray diffraction analysis.

  氯取代的烯氨基酮，即咪唑烷硝基氧化物的衍生物，与氰化钠反应得到相应的腈。反应通过形成环氧化物进行。这些环氧化物之一的结构通过 X 射线衍射分析得到证实。
• Reaction of 2-substituted 5,5-dimethyl-4-oxo-1-pyrroline-1-oxides with electrophilic reagents
  作者：V. A. Reznikov、L. A. Vishnivetskaya、L. B. Volodarskii

  DOI：10.1007/bf00960664

  日期：1990.2
• Stable vinylnitroxyl radicals, pyrroline derivatives
  作者：V. A. Reznikov、L. B. Volodarsky、T. V. Rybalova、Yu. V. Gatilov

  DOI：10.1007/bf02499074

  日期：1990.1
• ——
  作者：V. A. Reznikov、G. I. Roshchupkina、T. V. Ribalova、Yu. V. Gatilov

  DOI：10.1023/a:1011319528481

  日期：——

  The reaction of 4-(2R-1-chloro-2-oxoethylidene) -substituted imidazolidine-1-oxyl with sodium azide gives monoimines of alpha -diketones, derivatives of 3-imidazoline nitroxides. Reactions of these products with nitrogen binucleophiles were used to prepare various heterocyclic compounds containing an imidazoline nitroxide moiety.