<2-Chlor-propyl>-acetat | 627-68-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: <2-Chlor-propyl>-acetat
• 英文别名: 1-Propanol, 2-chloro, acetate；2-chloropropyl acetate
• CAS: 627-68-9
• 化学式: C₅H₉ClO₂
• 分子量: 136.578
• InChiKey: DXCQFTYOBQILML-UHFFFAOYSA-N

物化性质

• 保留指数：
  835;848;831;835;848;864

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  甲醇 、 <2-Chlor-propyl>-acetat 生成 2-氯-1-丙醇
  参考文献：
  名称：

  Henry, Recueil des Travaux Chimiques des Pays-Bas, 1903, vol. 22, p. 210,331

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2-丙二醇二乙酸酯 在 盐酸 作用下， 生成 <2-Chlor-propyl>-acetat
  参考文献：
  名称：

  Production of beta-chloro-alkyl esters of aliphatic acids

  摘要：

  公开号：

  US02038074A1

文献信息

• [EN] CONVERSION OF A MULTIHYDROXYLATED-ALIPHATIC HYDROCARBON OR ESTER THEREOF TO A CHLOROHYDRIN<br/>[FR] CONVERSION D'UN HYDROCARBURE ALIPHATIQUE MULTIHYDROXYLE OU L'UN DE SES ESTERS EN CHLOROHYDRINE
  申请人：DOW GLOBAL TECHNOLOGIES INC

  公开号：WO2006020234A1

  公开（公告）日：2006-02-23

  The present invention relates to a process for converting a multihydroxylated-aliphatic hydrocarbon or ester thereof to a chlorohydrin, by contacting the multihydroxylated-aliphatic hydrocarbon or ester thereof starting material with a source of a superatmospheric partial pressure of hydrogen chloride for a sufficient time and at a sufficient temperature, and wherein such contracting step is carried out without substantial removal of water, to produce the desired chlorohydrin product; wherein the desired product or products can be made in high yield without substantial formation of undesired overchlorinated byproducts. In addition, certain catalysts of the present invention may be used in the present process at superatmospheric, atmospheric and subatmospheric pressure conditions with improved results.

  本发明涉及一种将多羟基脂肪烃或其酯转化为氯水合物的方法，通过将多羟基脂肪烃或其酯起始物料与氯化氢的超大气分压源接触足够的时间和适当的温度，其中这种接触步骤在没有实质性去除水的情况下进行，以生产所需的氯水合物产品；所述所需产品或产品可以高产率地制备，而几乎不形成不需要的过氯化副产物。此外，本发明的某些催化剂可以在超大气压、大气压和次大气压条件下用于本方法，取得改进的结果。
• Regioselective synthesis of halohydrin esters from epoxides: reaction with acyl halides and rhodium-catalyzed three-component coupling reaction with alkyl halides and carbon monoxide
  作者：Koji Nakano、Shunsuke Kodama、Yessi Permana、Kyoko Nozaki

  DOI：10.1039/b912907c

  日期：——

  Regioselective synthesis of halohydrin esters was achieved by (1) the reaction of acyl halides with epoxides and (2) the rhodium-catalyzed three-component coupling reaction of alkyl halides, carbon monoxide, and epoxides.

  卤代醇酯的区域选择性合成是通过（1）酰卤与环氧化物的反应和（2）铑催化的卤代烷，一氧化碳和环氧化物的三组分偶联反应而实现的。
• 2-Aminopurine analogs having HSP90-inhibiting activity
  申请人：Kasibhatla Rao Srinivas

  公开号：US20050113340A1

  公开（公告）日：2005-05-26

  2-Aminopurine analogs are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.

  本文描述了2-氨基嘌呤类似物，并展示或预测其作为热休克蛋白90（HSP90）抑制剂，在治疗和预防各种HSP90介导的疾病，例如增殖性疾病方面具有实用性。还描述和声明了这些化合物的合成方法和使用方法。
• 2-Aminopurine Analogs Having HSP90-Inhibiting Activity
  申请人：Kasibhatla Rao Srinivas

  公开号：US20070185064A1

  公开（公告）日：2007-08-09

  2-Aminopurine analogs are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Method of synthesis and use of such compounds are also described and claimed.

  本文描述了2-氨基嘌呤类似物，并证明或预测其在治疗和预防各种HSP90介导的疾病（如增生性疾病）中作为HSP90抑制剂具有实用价值。还描述和声称了这种化合物的合成方法和使用方法。
• Pyridazinone derivatives
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP0947509A2

  公开（公告）日：1999-10-06

  This invention provides pyridazinone derivatives set forth in the formula: [wherein, R1, R2, R3, R4, R5 and R7 represent a hydrogen atom and the like, and R6 represents a C1-C3 alkyl and the like.]. The pyridazinone derivatives have excellent herbicidal activity.

  本发明提供了式中所述的哒嗪酮衍生物： [其中，R1、R2、R3、R4、R5 和 R7 代表氢原子等，R6 代表 C1-C3 烷基等]。 这些哒嗪酮衍生物具有优异的除草活性。