Tetracyclo[11.4.0.02,4.05,10]heptadeca-1(17),2(4),5,7,9,13,15-heptaen-3-one | 95495-93-5

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: Tetracyclo[11.4.0.02,4.05,10]heptadeca-1(17),2(4),5,7,9,13,15-heptaen-3-one
• CAS: 95495-93-5
• 化学式: C₁₇H₁₂O
• 分子量: 232.282
• InChiKey: VVEQMHOTGDSHAI-UHFFFAOYSA-N

物化性质

• 熔点：
  181-183 °C
• 沸点：
  463.9±45.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  Tetracyclo[11.4.0.02,4.05,10]heptadeca-1(17),2(4),5,7,9,13,15-heptaen-3-one 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 以83%的产率得到(E)-11,12-Dihydro-dibenzo[a,e]cyclooctene-5-carboxylic acid
  参考文献：
  名称：

  邻苯二甲酸二芳基酯的合成和本征合成

  摘要：

  通过直接的合成途径制备了一系列邻桥联的二芳基环丙烯酮。报道了新的环丙烯酮的光谱和化学性质。

  DOI：

  10.1016/s0040-4039(01)81475-1
• 作为产物：
  描述：

  10,11-二氢二苯并[a,b]环庚烯-5-酮 在 lithium aluminium tetrahydride 、 溴 、 potassium acetate 、 亚硝酸 、 三乙胺 作用下， 以 溶剂黄146 为溶剂， 生成 Tetracyclo[11.4.0.02,4.05,10]heptadeca-1(17),2(4),5,7,9,13,15-heptaen-3-one
  参考文献：
  名称：

  邻苯二甲酸二芳基酯的合成和本征合成

  摘要：

  通过直接的合成途径制备了一系列邻桥联的二芳基环丙烯酮。报道了新的环丙烯酮的光谱和化学性质。

  DOI：

  10.1016/s0040-4039(01)81475-1

文献信息

• Cyclopropenones and the Photochemical Generation of Cyclic Alkynes Therefrom
  申请人：Popik Vladimir V.

  公开号：US20100210854A1

  公开（公告）日：2010-08-19

  Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.

  环状炔烃（例如，二苯并环辛烯等）可以从环丙酮烯光化学地生成，如本文所披露的。这些环状炔烃可以与具有炔烃反应基团（例如，“点击”反应中的偶氮基团）的材料发生反应（例如，在原位）。在优选实施例中，环状炔烃的生成和反应可以在无催化剂（例如，Cu(I)）的情况下进行。这些反应可以用于例如，用于选择性标记通过含有偶氮基团表面单糖代谢修饰的活细胞，或用于光导向表面图案。
• CYCLOPROPENONES AND THE PHOTOCHEMICAL GENERATION OF CYCLIC ALKYNES THEREFROM
  申请人：POPIK VLADIMIR V.

  公开号：US20120295318A1

  公开（公告）日：2012-11-22

  Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.

  环状炔烃（例如，二苯并环辛炔烃等）可以从环丙酮中进行光化学合成，如本文所述。环状炔烃可以与具有炔基反应性基团的材料（例如“点击”反应中的偶氮基团）反应（例如原位反应）。在优选实施方式中，生成和反应环状炔烃可以在无催化剂（例如Cu（I））的情况下进行。例如，这些反应可以用于选择性标记代谢修饰有含偶氮基团表面单糖的活细胞，或用于光驱动表面图案化。
• EICHER, TH.;PIELARTZIK, H.;ZACHEUS, P., TETRAHEDRON LETT., 1984, 25, N 40, 4495-4498
  作者：EICHER, TH.、PIELARTZIK, H.、ZACHEUS, P.

  DOI：——

  日期：——
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.
• US8258347B2
  申请人：——

  公开号：US8258347B2

  公开（公告）日：2012-09-04