2,2-bis(hydroxymethyl)propionic stearyl ester | 954145-31-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-bis(hydroxymethyl)propionic stearyl ester
• 英文别名: Octadecyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate
• CAS: 954145-31-4
• 化学式: C₂₃H₄₆O₄
• 分子量: 386.616
• InChiKey: IZWHHWIQOLRWRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  27
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-bis(hydroxymethyl)propionic stearyl ester 在 4-二甲氨基吡啶 、 sodium hydroxide 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  新型线性树枝状羧酸盐表面活性剂的合成，胶束化和表面活性

  摘要：

  通过发散法合成了两代新型线性树突状羧酸盐表面活性剂C 18 -G 1-（COONa）2和C 18 -G 2-（COONa）4，其结构具有1 H核磁共振和红外光谱的特征分析。电导率测量用于测量C 18 ‐G 1‐（COONa）2和C 18 ‐G 2‐（COONa）4的Krafft温度，比相应的常规表面活性剂硬脂酸钠小得多。两种线性树突状表面活性剂的溶解度显着提高归因于羧酸根和酯基诱导的表面活性剂头基的高亲水性。从电导率和表面张力测量获得的临界胶束浓度（CMC）值表明，线性树突状表面活性剂的胶束化随着表面活性剂头基数量的增加而变得有利。但是，包括CMC处的表面张力，最大表面过量和最小表面积在内的表面活性参数表明，C 18 -G 1-（COONa）2与表面活性剂头基的空间排斥力不同，与C 18 -G 2-（COONa）4相比，在空气/水界面的吸收效率更高。另外，C 18 -G 1-（COONa）2和C

  DOI：

  10.1002/jsde.12455
• 作为产物：
  描述：

  在 5%-palladium/activated carbon 氢气 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 2,2-bis(hydroxymethyl)propionic stearyl ester
  参考文献：
  名称：

  PROCESSES FOR PREPARING DIFUNCTIONAL COMPOUNDS

  摘要：

  提供制备双丙烯酰基化合物的过程。这些过程包括将AB2单体与丙烯酰卤反应，然后进一步与长链单官能基脂肪化合物反应，形成长链双丙烯酸酯。进一步的过程包括将二官能腈化合物与丙烯酸反应，形成二官能双丙烯酸酯和双丙烯酰胺化合物。

  公开号：

  US20070255071A1

文献信息

• Processes for preparing difunctional compounds
  申请人：Odell Peter G.

  公开号：US20070255038A1

  公开（公告）日：2007-11-01

  Processes for preparing diacryl-functional compounds are provided. Processes include reacting AB 2 monomers with acryloyl halides, and then further reacting with long-chain, mono-functional aliphatic compounds to form long-chain diacrylates. Further processes include reacting difunctional tic compounds with acrylic acid to form difunctional diacrylate, and diacrylamide compounds.
• Compositions and methods for personal care
  申请人：Bitler Steven P.

  公开号：US20090246155A1

  公开（公告）日：2009-10-01

  Systems and methods for delivering personal care materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the cosmetic materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable.
• Systems and methods for delivery of drugs
  申请人：Taft David

  公开号：US20090263346A1

  公开（公告）日：2009-10-22

  Systems and methods for delivering drugs. Crystalline polymeric systems, referred to as CYC carriers, are associated with the drugs, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable.
• Systems and methods for delivery of materials for agriculture and aquaculture
  申请人：Taft David

  公开号：US20100004124A1

  公开（公告）日：2010-01-07

  Systems and methods for delivering agricultural (including aquacultural) materials. Crystalline polymeric systems, referred to as CYC carriers, are associated with the agricultural materials, through chemical bonding or through physical association. The crystallinity of the CYC carriers results from the presence of crystallizable side chains, for example long chain n-alkyl moieties, which results in relatively low and sharp melting temperatures. One class of CYC carriers, referred to as CYSC polymers, have a majority of the crystallizable side chains pendant from the polymer backbone. Another class of CYC carriers, referred to as ECC polymers, have a majority of the crystallizable side chains attached to terminal units of the polymer backbone. The ECC polymers can for example be obtained by modification of PLGA polymers. The CYC carriers in another class are non-polymeric. Some CYC carriers, referred to as CYC assemblies, have enhanced crystallinity as a result of the physical association of crystallizable moieties which are present in different types of molecule, for example between a polymer containing crystallizable moieties and a monomer containing crystallizable moieties. Preferably the CYC carrier is bioerodable.
• US7504531B2
  申请人：——

  公开号：US7504531B2

  公开（公告）日：2009-03-17