3-(3,4-dihydroxyphenyl)-N-prop-2-ynylpropanamide | 1260020-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(3,4-dihydroxyphenyl)-N-prop-2-ynylpropanamide
• CAS: 1260020-82-3
• 化学式: C₁₂H₁₃NO₃
• 分子量: 219.24
• InChiKey: YSESSVGAARHDEN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-二羟基苯基丙酸 、 炔丙胺 在 N-甲基吗啉 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 为溶剂， 反应 4.17h， 以58%的产率得到3-(3,4-dihydroxyphenyl)-N-prop-2-ynylpropanamide
  参考文献：
  名称：

  Helical poly(N-propargylamide)s with functional catechol groups: Synthesis and adsorption of metal ions in aqueous solution

  摘要：

  A novel type of helical N-propargylamide (PA) copolymer was synthesized by catalytic polymerization of monomer 1 (M1), which provided pendent functional catechol groups, and monomer 2 (M2), which endowed the expected copolymer backbones with helical structures. With [(nbd)Rh+B-(C6H5)(4) (nbd = 2,5-norbornadiene)] as catalyst, PA copolymers could be obtained with moderate molecular weights (3800-14,000) in high yields (>= 96%). The functional catechol groups enhanced the hydrophilicity of the hydrophobic mono-substituted polyacetylenes and aided the helical PA copolymers in showing a considerable adsorbance toward metal ions [Fe(III), Cr(III), Ni(II), Zn(II), Cu(II) and Cu(I)] in aqueous solution. The prepared copolymer in which Ml/M2 was 0.1/0.9 [mol/mol, poly(1(0.1)-co-2(0.9))] showed the highest adsorption capacity among the examined helical copolymers. In particular, for Fe(III), the maximum adsorption capacity was 186 mg g(-1). (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.reactfunctpolym.2010.09.006

文献信息

• (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide for treatment of neurodegenerative diseases
  申请人：THE UNIVERSITY OF HONG KONG

  公开号：US10259777B2

  公开（公告）日：2019-04-16

  The present invention pertains to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and (E)-3-(3,4-dihydroxyphenyl)-N-(prop-2-yn-1-yl)acrylamide of Formula (I): The invention also pertains to a method for stimulating neurite outgrowth by administering to cells in the area where neurite outgrowth is desired a therapeutically effective amount of the compound of Formula (I). Further, the invention pertains to a method for attenuating neuron injury in a subject by contacting a neuron in a subject in need thereof with a therapeutically effective amount of the compound of Formula (I). Furthermore, a method of preparing the compound of Formula (I) are provided.

  本发明涉及一种药物组合物，它包含一种药学上可接受的载体和式（I）的(E)-3-(3,4-二羟基苯基)-N-(丙-2-炔-1-基)丙烯酰胺： 本发明还涉及一种刺激神经元生长的方法，即向需要神经元生长区域的细胞施用治疗有效量的式（I）化合物。此外，本发明还涉及一种减轻受试者神经元损伤的方法，方法是将治疗有效量的式（I）化合物与有需要的受试者的神经元接触。此外，还提供了制备式（I）化合物的方法。
• Helical poly(N-propargylamide)s with functional catechol groups: Synthesis and adsorption of metal ions in aqueous solution
  作者：Lei Li、Yan Li、Xiaofeng Luo、Jianping Deng、Wantai Yang

  DOI：10.1016/j.reactfunctpolym.2010.09.006

  日期：2010.12

  A novel type of helical N-propargylamide (PA) copolymer was synthesized by catalytic polymerization of monomer 1 (M1), which provided pendent functional catechol groups, and monomer 2 (M2), which endowed the expected copolymer backbones with helical structures. With [(nbd)Rh+B-(C6H5)(4) (nbd = 2,5-norbornadiene)] as catalyst, PA copolymers could be obtained with moderate molecular weights (3800-14,000) in high yields (>= 96%). The functional catechol groups enhanced the hydrophilicity of the hydrophobic mono-substituted polyacetylenes and aided the helical PA copolymers in showing a considerable adsorbance toward metal ions [Fe(III), Cr(III), Ni(II), Zn(II), Cu(II) and Cu(I)] in aqueous solution. The prepared copolymer in which Ml/M2 was 0.1/0.9 [mol/mol, poly(1(0.1)-co-2(0.9))] showed the highest adsorption capacity among the examined helical copolymers. In particular, for Fe(III), the maximum adsorption capacity was 186 mg g(-1). (C) 2010 Elsevier Ltd. All rights reserved.