(+/-)-6-[(tert-butoxycarbonyl)amino]-1,2-epoxyhexane | 958635-13-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (+/-)-6-[(tert-butoxycarbonyl)amino]-1,2-epoxyhexane
• 英文别名: Tert-butyl N-[4-(oxiran-2-YL)butyl]carbamate；tert-butyl N-[4-(oxiran-2-yl)butyl]carbamate
• CAS: 958635-13-7
• 化学式: C₁₁H₂₁NO₃
• 分子量: 215.293
• InChiKey: VPAPZCVCODIULA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+/-)-6-[(tert-butoxycarbonyl)amino]-1,2-epoxyhexane 在 (AcO)[(S)-substituted salen]Co(III) 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.0h， 生成 (R)-6-[(tert-butoxycarbonyl)amino]-1,2-epoxyhexane 、 (S)-6-[(tert-butoxycarbonyl)amino]-1,2-epoxyhexane 、 (S)-6-[(tert-butoxycarbonyl)amino]-1,2-hexanediol 、 (R)-6-[(tert-butoxycarbonyl)amino]-1,2-hexanediol
  参考文献：
  名称：

  “盒式”原位酶筛选可识别互补的手性支架，用于一系列环氧化物的水解动力学拆分。

  摘要：

  ‘Cassette’-ISES (In Situ Enzymatic Screening) Identifies Complementary Chiral Scaffolds for Hydrolytic Kinetic Resolution Across a Range of Epoxides A new ‘Cassette’-In Situ Enzymatic Screen (ISES) for combinatorial catalysis is introduced. This allows the experimentalist to obtain an information-rich readout, in real time, providing an estimate of the sense and magnitude of enantioselectivity across more than one substrate. In its first iteration, the screen identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities.

  DOI：

  10.1002/anie.200701280

文献信息

• POLYANIONIC MULTIVALENT MACROMOLECULES FOR INTRACELLULAR TARGETING OF PROLIFERATION AND PROTEIN SYNTHESIS
  申请人：Licha Kai

  公开号：US20130095035A1

  公开（公告）日：2013-04-18

  The present invention relates generally to methods and compositions for targeting of intracellular molecules involved in proliferation and protein synthesis of activated cells using polyanionic multivalent macromolecules. In particular aspect, multiple sulfate groups linked to polyol are specifically targeted to the cytoplasm and nucleus of proliferating and activated cells. The invention further comprises novel polyanionic macromolecular compounds and formulations.
• US8877171B2
  申请人：——

  公开号：US8877171B2

  公开（公告）日：2014-11-04
• “Cassette” In Situ Enzymatic Screening Identifies Complementary Chiral Scaffolds for Hydrolytic Kinetic Resolution Across a Range of Epoxides
  作者：Sangeeta Dey、Douglas R. Powell、Chunhua Hu、David B. Berkowitz

  DOI：10.1002/anie.200701280

  日期：2007.9.17

  ‘Cassette’-ISES (In Situ Enzymatic Screening) Identifies Complementary Chiral Scaffolds for Hydrolytic Kinetic Resolution Across a Range of Epoxides A new ‘Cassette’-In Situ Enzymatic Screen (ISES) for combinatorial catalysis is introduced. This allows the experimentalist to obtain an information-rich readout, in real time, providing an estimate of the sense and magnitude of enantioselectivity across more than one substrate. In its first iteration, the screen identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities.