[(2R)-pent-4-en-2-yl] benzoate | 1355683-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(2R)-pent-4-en-2-yl] benzoate
• CAS: 1355683-78-1
• 化学式: C₁₂H₁₄O₂
• 分子量: 190.242
• InChiKey: QLQPHDBTEQSJKE-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [(2R)-pent-4-en-2-yl] benzoate 、 (R)-ethyl 3-(tert-butyldimethylsilyloxy)hex-5-enoate 在 对苯醌 、 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 二氯甲烷 为溶剂， 反应 20.17h， 生成
  参考文献：
  名称：

  [EN] SMALL MOLECULE COMPOUNDS FOR THE CONTROL OF NEMATODES
  [FR] COMPOSÉS À PETITE MOLÉCULES POUR LA LUTTE CONTRE LES NÉMATODES

  摘要：

  公开号：

  WO2013022985A3

文献信息

• Small Molecule Compounds for the Control of Nematodes
  申请人：Schroeder Frank C.

  公开号：US20140303360A1

  公开（公告）日：2014-10-09

  The present invention relates to compounds involved in nematode signaling.

  本发明涉及与线虫信号传导有关的化合物。
• Small Molecule Compounds that Control Mammal-Pathogenic Nematodes
  申请人：Choe Andrea

  公开号：US20140303102A1

  公开（公告）日：2014-10-09

  The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a mammal, and methods of treating or preventing parasite infection of a mammal.

  本发明涉及使用某些分离的调节剂化合物改变线虫行为的方法。本发明还揭示了促进或抑制线虫种群繁殖的方法，促进或抑制线虫在哺乳动物体内聚集的方法，以及治疗或预防哺乳动物的寄生虫感染的方法。
• Small Molecule Compounds That Control Plant- and Insect-Pathogenic Nematodes
  申请人：Choe Andrea

  公开号：US20140364386A1

  公开（公告）日：2014-12-11

  The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode population, methods of promoting or inhibiting nematode aggregation at a first location, and methods of treating or preventing parasite infection of a plant.

  本发明涉及使用某些孤立的调节化合物来改变线虫行为的方法。还公开了促进或抑制线虫种群繁殖的方法，促进或抑制线虫在第一位置的聚集的方法，以及用于治疗或预防植物寄生虫感染的方法。
• Comparative Metabolomics Reveals Biogenesis of Ascarosides, a Modular Library of Small-Molecule Signals in <i>C. elegans</i>
  作者：Stephan H. von Reuss、Neelanjan Bose、Jagan Srinivasan、Joshua J. Yim、Joshua C. Judkins、Paul W. Sternberg、Frank C. Schroeder

  DOI：10.1021/ja210202y

  日期：2012.1.25

  In the model organism Caenorhabditis elegans, a family of endogenous small molecules, the ascarosides function as key regulators of developmental timing and behavior that act upstream of conserved signaling pathways. The ascarosides are based on the dideoxysugar ascarylose, which is linked to fatty-acid-like side chains of varying lengths derived from peroxisomal beta-oxidation. Despite the importance of ascarosides for many aspects of C. elegans biology, knowledge of their structures, biosynthesis, and homeostasis remains incomplete. We used an MS/MS-based screen to profile ascarosides in C. elegans wild-type and mutant metabolomes, which revealed a much greater structural diversity of ascaroside derivatives than previously reported. Comparison of the metabolomes from wildtype and a series of peroxisomal beta-oxidation mutants showed that the enoyl CoA-hydratase MAOC-1 serves an important role in ascaroside biosynthesis and clarified the functions of two other enzymes, ACOX-1 and DHS-28. We show that, following peroxisomal beta-oxidation, the ascarosides are selectively derivatized with moieties of varied biogenetic origin and that such modifications can dramatically affect biological activity, producing signaling molecules active at low femtomolar concentrations. Based on these results, the ascarosides appear as a modular library of small-molecule signals, integrating building blocks from three major metabolic pathways: carbohydrate metabolism, peroxisomal beta-oxidation of fatty acids, and amino acid catabolism. Our screen further demonstrates that ascaroside biosynthesis is directly affected by nutritional status and that excretion of the final products is highly selective.
• US9445596B2
  申请人：——

  公开号：US9445596B2

  公开（公告）日：2016-09-20