N-dodecyl-N-methylformamide | 76058-02-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-dodecyl-N-methylformamide
• CAS: 76058-02-1
• 化学式: C₁₄H₂₉NO
• 分子量: 227.39
• InChiKey: JQVWURHUEOBNKK-UHFFFAOYSA-N

物化性质

• 沸点：
  342.1±11.0 °C(Predicted)
• 密度：
  0.860±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  十二烷基二甲基叔胺 在 benzyl(triethyl)ammoniumpermanganate 作用下， 以 二氯甲烷 为溶剂， 以42%的产率得到N-dodecyl-N-methylformamide
  参考文献：
  名称：

  Schmidt, H.-Juergen; Schaefer, Hans J., Angewandte Chemie, 1981, vol. 93, # 1, p. 124 - 125

  摘要：

  DOI：

文献信息

• N-Methylation of amine and nitro compounds with CO₂/H₂catalyzed by Pd/CuZrO_xunder mild reaction conditions
  作者：Xinjiang Cui、Yan Zhang、Youquan Deng、Feng Shi

  DOI：10.1039/c4cc05119j

  日期：——

  An active Pd/ZrCuOx catalyst was prepared for the reductive amination of CO2. The N-methylation of amines and nitro compounds with CO2/H2 can be realized with up to 97% yield under relatively mild reaction conditions. N-Formylation becomes the main reaction if the reaction was performed under milder conditions or using Pd/ZnZrOx as the catalyst.

  制备了一种活性 Pd/ZrCuOx 催化剂，用于二氧化碳的还原胺化反应。在相对温和的反应条件下，通过 CO2/H2 进行胺和硝基化合物的 N-甲基化反应，产率可高达97%。如果在更温和的条件下进行反应或使用 Pd/ZnZrOx 作为催化剂，N-甲酰化反应将成为主要反应。
• Ruthenium chloride catalysed oxidation of tertiary amines to amine oxides with molecular oxygen
  作者：Dennis P. Riley

  DOI：10.1039/c39830001530

  日期：——

  Tertiary amines are catalytically oxidized with molecular oxygen in homogeneous solutions containing RuCl3·xH2O to afford as a major product the corresponding N-oxide, the first example of such an oxidation.

  在含RuCl 3 · x H 2 O的均相溶液中，叔胺被分子氧催化氧化，得到相应的N-氧化物作为主要产物，这是这种氧化反应的第一个例子。
• Trifluorothymidine derivatives, process for producing the same and anti-cancer agent containing the same
  申请人：MITSUI TOATSU CHEMICALS, Inc.

  公开号：EP0517262A1

  公开（公告）日：1992-12-09

  Novel trifluorothymidine derivatives having anti-cancer activities are disclosed. The trifluorothymidine derivatives of the present invention are represented by the formula [I]: (wherein R¹ represents hydrogen atom or C₁ - C₄ alkyl group; R² represents hydrogen atom, C₁ - C₃₀ saturated or unsaturated alkyl-substituted carbonyl group, alkyl-substituted benzoyl group, C₁ - C₄ alkyloxycarbonyl group; dimethylaminoethyloxycarbonyl group, C₁ - C₄ alkyloxymethyl group, butoxyethoxyacetyl group, benzyl group, C₁ - C₂₀ alkyl-substituted silyl group, silyl group substituted with C₁ - C₁₀ alkyl group and/or phenyl group, C₁ - C₃₀ cyclic or chain alkyl-substituted carbamoyl group, diethylaminopropylcarbamoyl group, N-alkylpiperazinylacetyl group, N-alkylprolyl group, valyl group, trityl group, alkyl-substituted phosphoryl group or propargyl group; R³ represents hydrogen atom, C₁ - C₄ alkyl group, benzyl group, benzoyl group, C₁ - C₄ alkyloxy-substituted benzoyl group, furoyl group, C₁ - C₄ alkyloxymethyl group or C₁ - C₄ alkyl-substituted carbonyl group).

  本发明揭示了具有抗癌活性的新型三氟胸腺嘧啶衍生物。本发明的三氟胸腺嘧啶衍生物由式[I]表示：（其中R¹表示氢原子或C₁-C₄烷基；R²表示氢原子，C₁-C₃₀饱和或不饱和烷基取代的羰基基团，取代苯甲酰基团，C₁-C₄烷氧羰基基团；二甲氨基乙氧羰基基团，C₁-C₄烷氧甲基基团，丁氧乙氧乙酰基基团，苯甲基团，C₁-C₂₀烷基取代的硅基团，取代C₁-C₁₀烷基和/或苯基的硅基团，C₁-C₃₀环状或链状烷基取代的氨基甲酰基团，二乙氨基丙基氨基甲酰基团，N-烷基哌嗪基乙酰基团，N-烷基丙氧基基团，瓦林基团，三苯甲基基团，取代磷酸基团或丙炔基团的烷基；R³表示氢原子，C₁-C₄烷基，苯甲基，苯甲酰基，C₁-C₄烷氧取代的苯甲酰基团，呋喃基，C₁-C₄烷氧甲基基团或C₁-C₄烷基取代的羰基基团）。
• CONTINUOUS METHOD FOR THE HYDROGENATION OF AROMATIC COMPOUNDS
  申请人：Marie Sabrina

  公开号：US20120172632A1

  公开（公告）日：2012-07-05

  The invention relates to a continuous method for the catalytic hydrogenation of an aromatic compound into a cycloaliphatic compound, wherein said method is carried out in a piston reactor provided with a mechanical axially agitating means and comprises continuously feeding a liquid phase comprising said aromatic compound and a catalyst dispersed to the liquid phase, subjecting said liquid phase, at a temperature of between 100° C. and 300° C. and while being mechanical axially agitated, to the effects of a hydrogen pressure of between 10 and 250 bars in the presence of said catalyst dispersed in the liquid phase for a residence time of between 1 second and 10 minutes, and removing the liquid phase from the reactor.

  本发明涉及一种连续的催化氢化芳香化合物成环脂肪环化合物的方法，其中该方法在一个带有机械轴向搅拌装置的活塞反应器中进行，包括连续进料一种液相，该液相包含所述的芳香化合物和分散在液相中的催化剂，将所述的液相，在机械轴向搅拌的同时，在100℃到300℃的温度下，在存在分散在液相中的催化剂的条件下，承受10到250巴的氢气压力的影响，并在1秒到10分钟的停留时间内从反应器中移除液相。
• TETRAZOLINONE COMPOUNDS AND ITS USE
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150031733A1

  公开（公告）日：2015-01-29

  The present invention provides a compound having an excellent efficacy for controlling pests. A tetrazolinone compound of a formula (1): [wherein, R1 represents an C6-C16 aryl group, an C1-C12 alkyl group, a C3-C12 cycloalkyl group or an adamantyl group, etc., which each optionally be substituted; R2 represents a hydrogen atom, an C1-C12 alkyl group, or a halogen atom, etc.; R4 and R5 represent independently of each other a hydrogen atom or an C1-C3 alkyl group, etc.; R6, R7, R8 and R9 represent independently of each other a hydrogen atom, a halogen atom, an C1-C12 alkyl group, a C1-C12 haloalkyl group, an C2-C12 alkenyl group, a C3-C12 cycloalkyl group, an C1-C12 alkoxy group or a C1-C12 haloalkoxy group, etc.; X and Y represent independently of each other a sulfur atom or an oxygen atom; Q represents an oxygen atom or a sulfur atom; and R10 represents an C1-C6 alkyl group, etc.] shows an excellent controlling efficacy on pests.

  本发明提供了一种具有优异的杀虫功效的化合物。公式（1）的四唑酮化合物：[其中，R1代表C6-C16芳基，C1-C12烷基，C3-C12环烷基或金刚烷基等，每个都可以选择性地被取代；R2代表氢原子，C1-C12烷基或卤素原子等；R4和R5分别独立地代表氢原子或C1-C3烷基等；R6、R7、R8和R9分别独立地代表氢原子、卤素原子、C1-C12烷基、C1-C12卤代烷基、C2-C12烯基、C3-C12环烷基、C1-C12烷氧基或C1-C12卤代烷氧基等；X和Y分别独立地代表硫原子或氧原子；Q代表氧原子或硫原子；R10代表C1-C6烷基等]在控制害虫方面表现出优异的效果。