phenylimino-di-acetic acid bis-diethylamide | 101779-68-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phenylimino-di-acetic acid bis-diethylamide
• 英文别名: Phenylimino-di-essigsaeure-bis-diaethylamid；2,2'-(phenylazanediyl)bis(N,N-diethylacetamide)；2-(N-[2-(diethylamino)-2-oxoethyl]anilino)-N,N-diethylacetamide
• CAS: 101779-68-4
• 化学式: C₁₈H₂₉N₃O₂
• 分子量: 319.447
• InChiKey: VKGKIQHOJDMARY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N,N-二乙基-2-氯乙酰胺 生成 phenylimino-di-acetic acid bis-diethylamide
  参考文献：
  名称：

  Larizza; Brancaccio, Gazzetta Chimica Italiana, 1959, vol. 89, p. 2402,2404

  摘要：

  DOI：

文献信息

• SELECTIVE N-ALKYLATION OF PRIMARY AMINES WITH CHLOROACETAMIDES UNDER pH-CONTROLLED AQUEOUS CONDITIONS
  作者：Eric Loeser、Kapa Prasad、Oljan Repic

  DOI：10.1081/scc-120002124

  日期：——

  A practical method for selective alkylation of primary amines with chloroacetamides under modified Finkelstein conditions using stoichiometric amounts of sodium iodide in acetonitrile/water is described. An interesting finding in this study was that alpha-alkylaminoacetamides are less basic than the corresponding primary alkylamines by about 2pKa units; this necessitated a pH of 12 during alkylation to optimize the monoalkylation selectivity. Depending on the amount of primary amine used, mono: dialkylation selectivities ranged from 2.7 to 10.
• Larizza; Brancaccio, Gazzetta Chimica Italiana, 1959, vol. 89, p. 2402,2404
  作者：Larizza、Brancaccio

  DOI：——

  日期：——