N-<4-Methyl-phenyl>-propionamidin | 35403-00-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-<4-Methyl-phenyl>-propionamidin
• 英文别名: N'-(4-methylphenyl)propanimidamide
• CAS: 35403-00-0
• 化学式: C₁₀H₁₄N₂
• 分子量: 162.235
• InChiKey: YOIIAGGDJHNZOZ-UHFFFAOYSA-N

物化性质

• 沸点：
  233.2±33.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  38.4
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-<4-Methyl-phenyl>-propionamidin 在 三氯化硼 、 水 作用下， 以 甲苯 为溶剂， 生成
  参考文献：
  名称：

  A facile synthesis of 2,4-diaza-1-borines from anilines

  摘要：

  A general synthesis of diazaborines is described with the in situ preparation of amidines from anilines using a nitrile and AlCl3, followed by the addition of BCl3 and heating. The diazaborines were isolated as hydrochlorides in pure form and, in the case of 5, the structure was confirmed by an X-ray analysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00365-9
• 作为产物：
  描述：

  乙烷,三氯氟- 、 丙腈 在 三氯化铝 作用下， 以 甲苯 为溶剂， 生成 N-<4-Methyl-phenyl>-propionamidin
  参考文献：
  名称：

  A facile synthesis of 2,4-diaza-1-borines from anilines

  摘要：

  A general synthesis of diazaborines is described with the in situ preparation of amidines from anilines using a nitrile and AlCl3, followed by the addition of BCl3 and heating. The diazaborines were isolated as hydrochlorides in pure form and, in the case of 5, the structure was confirmed by an X-ray analysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00365-9

文献信息

• Process for the production of nitrogen compounds
  申请人：——

  公开号：US20030158442A1

  公开（公告）日：2003-08-21

  A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.

  一种合成方法，包括在硅烷化剂存在下，将含NH基团的化合物与硫氰酸盐、氰胺、亚硝酸盐或酯反应，以合成相应的含氮加成或取代产物。该方法不仅能够直接高效地合成包括异硫脲、胍胺、胍甲胺和酰胺在内的含氮化合物，而且具有广泛的应用范围，适用于大规模合成。
• Method for preparing nitrogen-containing compounds
  申请人：Emura Takashi

  公开号：US20050043569A1

  公开（公告）日：2005-02-24

  A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.

  一种合成方法，包括在硅烷化剂存在下，将NH基团含有的化合物与硫氰酸盐、氰胺、亚硝酸盐或酯反应，以合成相应的含氮加成或取代产物。该方法不仅能够直接高效地合成包括异硫脲、胍、酰胺和酰胺类化合物在内的含氮化合物，而且具有广泛的应用范围，适用于大规模合成。
• PROCESS FOR THE PRODUCTION OF NITROGEN COMPOUNDS
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1285909A1

  公开（公告）日：2003-02-26

  A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitriles or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis.

  一种合成方法，包括在硅烷化剂存在下使含 NH 基团的化合物与硫氰酸盐、氰胺、腈或酯反应，以合成相应的含氮加成或取代产物。 这种方法不仅能直接有效地合成含氮化合物，包括异硫脲类、胍类、脒类和酰胺类，而且应用广泛，适合大规模合成。
• US6803472B2
  申请人：——

  公开号：US6803472B2

  公开（公告）日：2004-10-12
• US6960689B2
  申请人：——

  公开号：US6960689B2

  公开（公告）日：2005-11-01