sulfanilic acid-(4-heptyl-6-methyl-pyrimidin-2-ylamide) | 107923-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sulfanilic acid-(4-heptyl-6-methyl-pyrimidin-2-ylamide)
• 英文别名: Sulfanilsaeure-(4-heptyl-6-methyl-pyrimidin-2-ylamid)；N'-(4-heptyl-6-methyl-2-pyrimidinyl)sulfanilamide；4-amino-N-(4-heptyl-6-methylpyrimidin-2-yl)benzenesulfonamide
• CAS: 107923-98-8
• 化学式: C₁₈H₂₆N₄O₂S
• 分子量: 362.496
• InChiKey: SHNMWMQDTKOPMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-[bis(4-methoxyphenyl)methyl-[2-(4-bromophenyl)ethyl]amino]-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol 、 sulfanilic acid-(4-heptyl-6-methyl-pyrimidin-2-ylamide) 在 tris-(dibenzylideneacetone)dipalladium(0) 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 sodium t-butanolate 、 溶剂黄146 作用下， 以 甲苯 、 水 为溶剂， 反应 10.0h， 生成 N-(4-heptyl-6-methylpyrimidin-2-yl)-4-((4-(2-((2-hydroxy-2-(4-hydroxy-3-(hydroxymethyl)phenyl)ethyl)amino)ethyl)phenyl)amino)benzenesulfonamide 2,2,2-trifluoroacetate
  参考文献：
  名称：

  Aryl aniline beta2 adrenergic receptor agonists

  摘要：

  这项发明提供了式（I）的新型β2肾上腺素受体激动剂化合物： 其中R1-R13和w具有规范中描述的任何值。该发明还提供了这些化合物与其他治疗剂的组合，包含这些化合物和组合物的药物组合物，使用这些化合物治疗与β2肾上腺素受体活性相关的疾病的方法，以及用于制备这些化合物的有用的过程和中间体。

  公开号：

  US20030229058A1
• 作为产物：
  描述：

  2-壬酮 在 硫酸 作用下， 生成 sulfanilic acid-(4-heptyl-6-methyl-pyrimidin-2-ylamide)
  参考文献：
  名称：

  Lateral Stability During Forward-Induced Stepping for Dynamic Balance Recovery in Young and Older Adults

  摘要：

  Background. Balance dysfunction related to lateral instability has been associated with falls and fall-related injuries among older individuals. Protective stepping for dynamic balance recovery requires the effective control of lateral body motion, This study investigated the relationship between aging, falls, and lateral stability during forward-induced stepping for dynamic balance recovery.Methods. Forward steps were induced by a motor-driven waist-pull system in 12 younger adults, 20 healthy community-dwelling older adult nonfallers, and IS older adults who had reported falls. Group differences in kinetic and kinematic stepping characteristics for a range of Postural disturbance magnitudes were evaluated.Results. Despite group similarities in anticipatory postural adjustments for minimizing lateral instability, the older fallers demonstrated significantly greater sideways body motion toward the stepping side at first-step foot contact and a more laterally directed foot placement. During the first step, forward-stepping characteristics were generally comparable between the groups, but the older falters had an earlier liftoff time and longer step duration.Conclusions. During forward-induced protective stepping, otherwise healthy older adults who had experienced falls showed particular differences in their control of lateral body motion that were not attributable to changes in anticipatory postural mechanisms. Aging changes in controlling lateral body motion during protective stepping appear to involve factors that intervene between the first-step liftoff and foot contact and/or adaptations in stepping patterns related to prior planning.

  DOI：

  10.1093/gerona/56.9.m589

文献信息

• [EN] ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONISTS<br/>[FR] AGONISTES ARYLANILINE DES RECEPTEURS ADRENERGIQUES DOLLAR G(B)2
  申请人：THERAVANCE INC

  公开号：WO2003042164A1

  公开（公告）日：2003-05-22

  The invention provides novel β2 adrenergic receptor agonist compounds of formula (I): wherein R1-R13 and w have any of the values described in the specification. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β¿2? adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

  本发明提供了一种新的β2肾上腺素受体激动剂化合物，其化学式为(I)：其中R1-R13和w具有规范中描述的任何值。本发明还提供了包含这种化合物的药物组合物，使用这种化合物治疗与β2肾上腺素受体活性相关的疾病的方法，以及用于制备这种化合物的过程和中间体。
• ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONISTS
  申请人：Theravance, Inc.

  公开号：EP1446379A1

  公开（公告）日：2004-08-18
• COMBINATIONS OF AN ARYL ANILINE BETA-2 ADRENERGIC RECEPTOR AGONIST AND A CORTICOSTEROID
  申请人：Theravance, Inc.

  公开号：EP1641465A2

  公开（公告）日：2006-04-05
• US6670376B1
  申请人：——

  公开号：US6670376B1

  公开（公告）日：2003-12-30
• US7125892B2
  申请人：——

  公开号：US7125892B2

  公开（公告）日：2006-10-24