5-{4-[1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4,4,5,5-tetramethyl-imidazolidin-2-yl]-phenyl}-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione | 847659-11-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-{4-[1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4,4,5,5-tetramethyl-imidazolidin-2-yl]-phenyl}-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
• 英文别名: 5-[4-[1,3-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,5,5-tetramethylimidazolidin-2-yl]phenyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 847659-11-4
• 化学式: C₃₄H₅₈N₄O₇Si₂
• 分子量: 691.028
• InChiKey: WHEKYVYIJGYROM-OYUWMTPXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.89
• 重原子数：
  47
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  5-{4-[1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4,4,5,5-tetramethyl-imidazolidin-2-yl]-phenyl}-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione 在 吡啶 、 四氮唑 作用下， 以 甲苯 、 乙腈 为溶剂， 反应 26.0h， 生成 3-[[(2R,3S,5R)-5-[5-[4-[1,3-bis[[tert-butyl(dimethyl)silyl]oxy]-4,4,5,5-tetramethylimidazolidin-2-yl]phenyl]-2,4-dioxopyrimidin-1-yl]-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
  参考文献：
  名称：

  Synthesis and ESR studies of nitronyl nitroxide-tethered oligodeoxynucleotides

  摘要：

  We report oil the development of a nucleoside labeled with a nitronyl nitroxide group, U-NN, and the synthesis of oligodeoxynucleotides containing U-NN. The spin signals of U-NN. containing oligodeoxynucleotides varied with the degree of hybridization of the complementary strand and the distance between nitronyl nitroxide spins. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.12.012
• 作为产物：
  描述：

  碘苷 在 四(三苯基膦)钯 吡啶 、 咪唑 、 ammonium hydroxide 、 sodium hydroxide 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 35.0h， 生成 5-{4-[1,3-Bis-(tert-butyl-dimethyl-silanyloxy)-4,4,5,5-tetramethyl-imidazolidin-2-yl]-phenyl}-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis and ESR studies of nitronyl nitroxide-tethered oligodeoxynucleotides

  摘要：

  We report oil the development of a nucleoside labeled with a nitronyl nitroxide group, U-NN, and the synthesis of oligodeoxynucleotides containing U-NN. The spin signals of U-NN. containing oligodeoxynucleotides varied with the degree of hybridization of the complementary strand and the distance between nitronyl nitroxide spins. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.12.012

文献信息

• Synthesis and ESR studies of nitronyl nitroxide-tethered oligodeoxynucleotides
  作者：Akimitsu Okamoto、Takeshi Inasaki、Isao Saito

  DOI：10.1016/j.tetlet.2004.12.012

  日期：2005.1

  We report oil the development of a nucleoside labeled with a nitronyl nitroxide group, U-NN, and the synthesis of oligodeoxynucleotides containing U-NN. The spin signals of U-NN. containing oligodeoxynucleotides varied with the degree of hybridization of the complementary strand and the distance between nitronyl nitroxide spins. (C) 2004 Elsevier Ltd. All rights reserved.