5-(3"-aminoallyl)-2'-deoxyuridine | 195829-10-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 5-(3"-aminoallyl)-2'-deoxyuridine
• 英文别名: 5-(3''-aminoallyl)-2'-deoxyuridine；5-(3-Amino-propenyl)-1-(4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione；5-[(E)-3-aminoprop-1-enyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• CAS: 195829-10-8
• 化学式: C₁₂H₁₇N₃O₅
• 分子量: 283.284
• InChiKey: WAMWATABORFTJY-HFVMFMDWSA-N

物化性质

• 密度：
  1.520±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-(3"-aminoallyl)-2'-deoxyuridine 在 吡啶 、 4-二甲氨基吡啶 、 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 生成 5'-O-(4-dimethoxytrityl)-5-(3''-δ-ketohexanamidoallyl)-2'-deoxyuridine
  参考文献：
  名称：

  Ketone-DNA:  A Versatile Postsynthetic DNA Decoration Platform

  摘要：

  [GRAPHICS]A general strategy for the functional diversification of DNA, oligonucleotides under physiological conditions was developed. We describe the synthesis of DNA molecules bearing ketone ports (ketone-DNA) and the efficient postsynthetic decoration of ketone-DNA with structurally diverse aminooxy compounds.

  DOI：

  10.1021/ol016626r
• 作为产物：
  描述：

  碘苷 在 sodium tetrachloropalladate ammonium hydroxide 作用下， 以 acetate buffer 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 5-(3"-aminoallyl)-2'-deoxyuridine
  参考文献：
  名称：

  A cysteine-appended deoxyuridine for the postsynthetic DNA modification using native chemical ligation

  摘要：

  A new deoxyuridine derivative 6 bearing a cysteine group at the C5 position was synthesized and incorporated into oligodeoxynucleotide (ODN) by phosphoramidite chemistry. The postsynthetic DNA modification of the cysteine-containing ODN using native chemical ligation with thioesters of biotin and green fluorescent protein variant was successfully demonstrated. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.02.018

文献信息

• Compositions and methods for inhibiting Factor D
  申请人：Vitrisa Therapeutics, Inc.

  公开号：US10174325B2

  公开（公告）日：2019-01-08

  The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease.

  该申请公开了抑制替代补体途径的方法和组合物。该申请进一步提供了用于治疗干性老年性黄斑变性、地理萎缩、湿性老年性黄斑变性或斯塔加特病的抗因子 D 合剂。
• Compositions with improved intravitreal half-life and uses thereof
  申请人：Vitrisa Therapeutics, Inc.

  公开号：US10308943B2

  公开（公告）日：2019-06-04

  Provided herein are compositions and methods for the treatment of retinal diseases. The compositions and methods include a therapeutic agent conjugated to a vitreous component binding moiety. The vitreous component binding moiety may be an aptamer or a small molecule that binds to a structural component of the vitreous humor (e.g., hyaluronic acid, collagen or vitronectin).

  本文提供了用于治疗视网膜疾病的组合物和方法。这些组合物和方法包括与玻璃体成分结合分子共轭的治疗剂。玻璃体成分结合分子可以是与玻璃体结构成分（如透明质酸、胶原蛋白或玻璃连蛋白）结合的配合物或小分子。
• Stem-loop compositions and methods for inhibiting factor D
  申请人：Vitrisa Therapeutics, Inc.

  公开号：US10428330B2

  公开（公告）日：2019-10-01

  The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease. In some cases, stem-loop aptamers are provided for the inhibition of Factor D.

  该申请公开了抑制替代补体途径的方法和组合物。该申请进一步提供了用于治疗干性年龄相关性黄斑变性、地理萎缩、湿性年龄相关性黄斑变性或斯塔加特病的抗因子 D 配合物。在某些情况下，提供了用于抑制因子 D 的干环适配体。
• Compositions and methods for inhibiting factor D
  申请人：396419 B.C. Ltd.

  公开号：US11274307B2

  公开（公告）日：2022-03-15

  The application discloses methods and compositions for the inhibition of the alternative complement pathway. The methods and compositions involve the use of aptamers for inhibiting complement Factor D. The application further provides anti-Factor D aptamers for the treatment of dry age-related macular degeneration, geographic atrophy, wet age-related macular degeneration or Stargardt disease.

  该申请公开了抑制替代补体途径的方法和组合物。该申请进一步提供了用于治疗干性老年性黄斑变性、地理萎缩、湿性老年性黄斑变性或斯塔加特病的抗因子 D 合剂。
• ENZYMATIC REDOX LABELLING OF NUCLEIC ACIDS
  申请人：UNISEARCH LIMITED

  公开号：EP1468006A1

  公开（公告）日：2004-10-20