4-hydrazinocarbonyl-benzoic acid ethyl ester | 19827-16-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydrazinocarbonyl-benzoic acid ethyl ester
• 英文别名: Terephthalsaeure-aethylester-hydrazid；4-Carbazoyl-benzoesaeure-aethylester；4-Aethoxycarbonyl-benzoesaeure-hydrazid；p-Ethoxycarbonyl-benzoesaeure-hydrazid；p-Carbaethoxybenzoesaeurehydrazid；4-Aethoxycarbonyl-benzhydrazid；Ethyl 4-(hydrazinecarbonyl)benzoate
• CAS: 19827-16-8
• 化学式: C₁₀H₁₂N₂O₃
• 分子量: 208.217
• InChiKey: URSWERDHEXWZBT-UHFFFAOYSA-N

物化性质

• 熔点：
  164-165 °C
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-hydrazinocarbonyl-benzoic acid ethyl ester 在 氯磺酸 、 氢氧化钾 作用下， 反应 3.0h， 生成 4-[5-(4-羧基苯基)-1,3,4-恶二唑-2-基]苯甲酸
  参考文献：
  名称：

  New ox-diazole compounds and process for their manufacture

  摘要：

  公开号：

  US02765304A1
• 作为产物：
  描述：

  对苯二甲酸二乙酯 在 一水合肼 作用下， 生成 4-hydrazinocarbonyl-benzoic acid ethyl ester
  参考文献：
  名称：

  Davidis, Journal fur praktische Chemie (Leipzig 1954), 1896, vol. <2>54, p. 85

  摘要：

  DOI：

文献信息

• Synthesis and biological evaluation of oxoindolin-3-ylidene ethyl benzothiohydrazides as non-peptide TPO mimics
  作者：Peng Cho Tang、He Jun Lu、Yi Qian Chen、Sheng Lan Wang、Hao Zheng、Li Wang

  DOI：10.1016/j.bmcl.2010.07.040

  日期：2010.9

  A novel series of oxoindolin-3-ylidene ethyl benzohydrazides were designed, synthesized, and identified as small molecule agonists of thrombopoietin (TPO) receptor c-mpl. Sulfur–oxygen exchange in oxoindolin-3-ylidene ethyl benzohydrazides was found to improve their agonistic activities. Several oxoindolin-3-ylidene ethyl benzothiohydrazides have been identified as full agonists of c-mpl.

  设计，合成和鉴定了一系列新的氧代吲哚-3-亚乙基乙基苯甲酰肼，作为血小板生成素（TPO）受体c-mpl的小分子激动剂。发现氧代吲哚-3-亚乙基乙基苯甲酰肼中的硫-氧交换改善了它们的激动活性。几种氧代吲哚-3-亚乙基乙基苯并硫酰肼已被鉴定为c-mpl的完全激动剂。
• Photocatalyzed facile synthesis of 2,5-diaryl 1,3,4-oxadiazoles with polyaniline- g-C3N4-TiO2 composite under visible light
  作者：Liang Wang、Yaoyao Wang、Qun Chen、Mingyang He

  DOI：10.1016/j.tetlet.2018.03.005

  日期：2018.4

  PANI (polyaniline)-g-C3N4-TiO2 composite was prepared and found to be efficient for the synthesis of 2,5-diaryl 1,3,4-oxadiazoles under visible light. This reaction involved decarboxylation and cyclization from cc-keto acids with acylhydrazines, and a broad scope of substrates were tolerated to provide the desired products in moderate to good yields. Control experiments indicated that a radical pathway was involved in the present photocatalytic reaction and a synergistic effect may exist in the ternary composite. Moreover, this semiconductor photocatalyst could be readily recovered and showed good reusability with only slight decrease in the catalytic activity after six consecutive runs. (C) 2018 Elsevier Ltd. All rights reserved.
• Heinisch; Hanschke; Willitzer, Pharmazie, 1992, vol. 47, # 6, p. 412 - 415
  作者：Heinisch、Hanschke、Willitzer、Mollmann、Tresselt、Stengel、Eckardt、Kleinwachter

  DOI：——

  日期：——
• Grekow et al., Zhurnal Obshchei Khimii, 1959, vol. 29, p. 2027,2030; engl. Ausg. S. 1996, 1998
  作者：Grekow et al.

  DOI：——

  日期：——
• Synthesis and properties of hydrazones of the antitumor antibiotic rubomycin
  作者：Yu. A. Rozin、E. I. Buryndina、R. Kh. Batulina、T. M. Bobrova、L. V. Krupnova、A. S. Barybin

  DOI：10.1007/bf00758626

  日期：1987.6