10,17-dihydroxy DHA | 887752-08-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 10,17-dihydroxy DHA
• 英文别名: (4Z,7Z,11Z,13Z,15E,19Z)-10,17-dihydroxydocosa-4,7,11,13,15,19-hexaenoic acid
• CAS: 887752-08-1
• 化学式: C₂₂H₃₂O₄
• 分子量: 360.494
• InChiKey: CRDZYJSQHCXHEG-GWNDGJBTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二十二碳六烯酸 在 15-lipoxygenase 水 、 sodium tetrahydroborate 作用下， 以 水 为溶剂， 反应 0.5h， 生成 (±)-(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosa-4,7,10,13,15,19-hexaenoic acid 、 7,17-dihydroxy DHA 、 10,17-dihydroxy DHA
  参考文献：
  名称：

  WO2006/55965

  摘要：

  公开号：

文献信息

• Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
  申请人：Nauroth Julie

  公开号：US20090318394A1

  公开（公告）日：2009-12-24

  Disclosed are compositions containing DHA and DPAn-6 and methods of administering and using the same to treat or prevent at least one symptom of inflammation or neurodegeneration or disease states associated with inflammation or neurodegeneration. Also discloses are compositions containing specific dosages and/or ratios of long chain polyunsaturated fatty acids that are particularly effective in reducing or preventing symptoms of inflammation or neurodegeneration.
• Oxylipins From Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
  申请人：Arterburn Linda

  公开号：US20110178047A1

  公开（公告）日：2011-07-21

  Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.
• US7884131B2
  申请人：——

  公开号：US7884131B2

  公开（公告）日：2011-02-08
• WO2006/55965
  申请人：——

  公开号：——

  公开（公告）日：——