Thr-Cys | 186761-52-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Thr-Cys
• 英文别名: (2R)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-sulfanylpropanoic acid
• CAS: 186761-52-4
• 化学式: C₇H₁₄N₂O₄S
• 分子量: 222.26
• InChiKey: CUTPSEKWUPZFLV-WISUUJSJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  114
• 氢给体数：
  5
• 氢受体数：
  6

文献信息

• Pseudo-antibody constructs
  申请人：——

  公开号：US20030211078A1

  公开（公告）日：2003-11-13

  This invention relates to novel pharmaceutically useful compositions that bind to a biological molecule, having improved circulatory half-life, increased avidity, increased affinity, or multifunctionality, and methods of use thereof. The present invention provides a pseudo-antibody comprising an organic moiety covalenty coupled to at least two target-binding moieties, wherein the target-binding moieties are selected from the group consisting of a protein, a peptide, a peptidomimetic, and a non-peptide molecule that binds to a specific targeted biological molecule. The pseudo-antibody of the present invention may affect a specific ligand in vitro, in situ and/or in vivo. The pseudo-antibodies of the present invention can be used to measure or effect in an cell, tissue, organ or animal (including humans), to diagnose, monitor, modulate, treat, alleviate, help prevent the incidence of, or reduce the symptoms of, at least one condition.

  本发明涉及与生物分子结合的新型药用组合物，该组合物具有更好的循环半衰期、更高的活性、更高的亲和力或多功能性，以及其使用方法。本发明提供了一种伪抗体，它包括与至少两个靶向结合分子共价偶联的有机分子，其中靶向结合分子选自由蛋白质、肽、肽模拟物和与特定靶向生物分子结合的非肽分子组成的组。本发明的假抗体可在体外、原位和/或体内影响特定配体。本发明的假抗体可用于测量或影响细胞、组织、器官或动物（包括人类），以诊断、监测、调节、治疗、缓解、帮助预防至少一种病症的发生或减轻其症状。
• [EN] PSEUDO-ANTIBODY CONSTRUCTS<br/>[FR] CONSTRUCTIONS DE PSEUDO-ANTICORPS
  申请人：CENTOCOR INC

  公开号：WO2003049684A2

  公开（公告）日：2003-06-19

  This invention relates to novel pharmaceutically useful compositions that bind to a biological molecule, having improved circulatory half-life, increased avidity, increased affinity, or multifunctionality, and methods of use thereof. The present invention provides a pseudo-antibody comprising an organic moiety covalenty coupled to at least two target-binding moieties, wherein the target-binding moieties are selected from the group consisting of a protein, a peptide, a peptidomimetic, and a non-peptide molecule that binds to a specific targeted biological molecule. The pseudo-antibody of the present invention may affect a specific ligand in vitro, in situ and/or in vivo. The pseudo-antibodies of the present invention can be used to measure or effect in an cell, tissue, organ or animal (including humans), to diagnose, monitor, modulate, treat, alleviate, help prevent the incidence of, or reduce the symptoms of, at least one condition.
• [EN] PROTEIN GLYCATION SUPPRESSANT<br/>[FR] SUPPRESSEUR DE GLYCATION DE PROTÉINE<br/>[JA] タンパク質糖化抑制剤
  申请人：AJINOMOTO KK

  公开号：WO2020071258A1

  公开（公告）日：2020-04-09

  本発明の課題は、優れた抗糖化機能を示す組成物等を提供する。特に、幅広い終末糖化産物に対して抗糖化機能を示し、さらに抗酸化機能を有しつつ、化粧料等に使用しても着色し難く、安全性・生体適合性の高い成分を提供すること、幅広い終末糖化産物に対して抗糖化機能を示し、さらに抗酸化機能を有しつつ、安定性、安全性、生体適合性の高い成分を含む組成物等を提供すること。本発明は、炭素原子数が３以上の中性アミノ酸又はその塩を有効成分として含有することを特徴とするタンパク質糖化抑制剤、並びに酸性アミノ酸、塩基性アミノ酸、ヒドロキシアミノ酸、分岐鎖アミノ酸、及び抗酸化性のアミノ酸からなる群から選ばれるアミノ酸を構成アミノ酸とし、且つＣ末端側の構成アミノ酸が、抗酸化性のアミノ酸であるジペプチド又はその塩を有効成分として含有することを特徴とするタンパク質糖化抑制剤。