Ethyl 6-[4-[hydroxy(methyl)carbamoyl]phenoxy]hexanoate | 406943-91-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 6-[4-[hydroxy(methyl)carbamoyl]phenoxy]hexanoate
• 英文别名: ethyl 6-[4-[hydroxy(methyl)carbamoyl]phenoxy]hexanoate
• CAS: 406943-91-7
• 化学式: C₁₆H₂₃NO₅
• 分子量: 309.362
• InChiKey: CVGRJPAJUPJYFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [Ru(2,2'-bipyridine)2]CO3 、 Ethyl 6-[4-[hydroxy(methyl)carbamoyl]phenoxy]hexanoate 以 not given 为溶剂， 生成 [(2,2-bipyridine)2Ru(CH3NOCOC6H5O(CH2)5COOEt)](NO3)
  参考文献：
  名称：

  Redox-Active Metal-Containing Nucleotides:  Synthesis, Tunability, and Enzymatic Incorporation into DNA

  摘要：

  Novel redox-active DNA labeling tags with tunable electrochemical potentials are modularly synthesized using (a) bis-substituted Ru2+ or Os2+ precursors (R2bpy)2ML2, (b) substituted 2,4-pentanediones or hydroxamic acids bearing a functionalized linker, and (c) modified nucleotides. DNA polymerase efficiently incorporates the metal-containing nucleotide triphosphate into DNA oligonucleotides.

  DOI：

  10.1021/ja017193q
• 作为产物：
  描述：

  对羟基苯甲酸苄酯 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 、 sodium hydride 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.5h， 生成 Ethyl 6-[4-[hydroxy(methyl)carbamoyl]phenoxy]hexanoate
  参考文献：
  名称：

  Redox-Active Metal-Containing Nucleotides:  Synthesis, Tunability, and Enzymatic Incorporation into DNA

  摘要：

  Novel redox-active DNA labeling tags with tunable electrochemical potentials are modularly synthesized using (a) bis-substituted Ru2+ or Os2+ precursors (R2bpy)2ML2, (b) substituted 2,4-pentanediones or hydroxamic acids bearing a functionalized linker, and (c) modified nucleotides. DNA polymerase efficiently incorporates the metal-containing nucleotide triphosphate into DNA oligonucleotides.

  DOI：

  10.1021/ja017193q

文献信息

• Redox-Active Metal-Containing Nucleotides:  Synthesis, Tunability, and Enzymatic Incorporation into DNA
  作者：Haim Weizman、Yitzhak Tor

  DOI：10.1021/ja017193q

  日期：2002.2.1

  Novel redox-active DNA labeling tags with tunable electrochemical potentials are modularly synthesized using (a) bis-substituted Ru2+ or Os2+ precursors (R2bpy)2ML2, (b) substituted 2,4-pentanediones or hydroxamic acids bearing a functionalized linker, and (c) modified nucleotides. DNA polymerase efficiently incorporates the metal-containing nucleotide triphosphate into DNA oligonucleotides.