dodecyl hydrogen sulfate;(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol | 106525-44-4

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: dodecyl hydrogen sulfate;(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
• CAS: 106525-44-4
• 化学式: C32H50N2O6S
• 分子量: 590.8
• InChiKey: DIGLODHVPMVAEM-DSXUQNDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  41
• 可旋转键数：
  16
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Pharmaceutical formulations comprising sodium laurylsulfate as bitterness masking agent
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP1452177A1

  公开（公告）日：2004-09-01

  The present invention refers to a new bitterness masking agent for pharmaceutical formulations which are to be applied orally. It was found that certain pharmaceutically acceptable surfactants can mask the bitter taste of some bitter tasting pharmaceutically active compounds. The present invention in particular concerns epinastine or quinine comprising formulations.

  本发明涉及一种用于口服药物配方的新型苦味掩蔽剂。研究发现，某些药学上可接受的表面活性剂可以掩盖某些苦味药用活性化合物的苦味。本发明尤其涉及由依匹斯汀或奎宁组成的制剂。
• [EN] PHARMACEUTICAL FORMULATIONS COMPRISING SODIUM LAURYLSULFATE AS BITTERNESS MASKING AGENT<br/>[FR] PREPARATIONS PHARMACEUTIQUES COMPRENANT DE NOUVEAUX AGENTS DE MASQUAGE DE GOUT AMER
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2004075900A2

  公开（公告）日：2004-09-10

  The present invention refers to a new bitterness masking agent for pharmaceutical formulations which are to be applied orally. It was found that certain pharmaceutically acceptable surfactants can mask the bitter taste of some bitter tasting pharmaceutically active compounds. The present invention in particular concerns epinastine or quinine comprising formulations.