1,1-pentadecanedicarboxylic acid | 4475-23-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,1-pentadecanedicarboxylic acid
• 英文别名: tetradecyl-malonic acid；Tetradecyl-malonsaeure；2-tetradecylmalonic acid；tetradecylmalonic acid；1,1-Pentadecandicarbonsaeure；Malonic acid, tetradecyl-；2-tetradecylpropanedioic acid
• CAS: 4475-23-4
• 化学式: C₁₇H₃₂O₄
• 分子量: 300.439
• InChiKey: SMTKGALBDOEZCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  21
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2917190090

反应信息

• 作为反应物：
  描述：

  1,1-pentadecanedicarboxylic acid 生成 棕榈酸
  参考文献：
  名称：

  Chargaff, Chemische Berichte, 1932, vol. 65, p. 752

  摘要：

  DOI：
• 作为产物：
  描述：

  2-tetradecyl-malonamic acid 在 potassium carbonate 作用下， 生成 1,1-pentadecanedicarboxylic acid
  参考文献：
  名称：

  Hell; Jordanow, Chemische Berichte, 1891, vol. 24, p. 990

  摘要：

  DOI：

文献信息

• [EN] LPA RECEPTOR AGONISTS AND ANTAGONISTS<br/>[FR] AGONISTES DES RÉCEPTEURS DE LPA ET ANTAGONISTES
  申请人：RXBIO INC

  公开号：WO2010051053A1

  公开（公告）日：2010-05-06

  Disclosed are compounds according to formula (I) as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including treating cancer, producing radioprotection and/or radiomitigation, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermato logical condition.

  揭示了按照式(I)的化合物，以及包括这些化合物的药物组合物。还揭示了使用这些化合物的方法，这些方法具有作为LPA受体激动剂或拮抗剂的活性；这些方法包括治疗癌症、产生放射保护和/或减轻放射损伤、增强细胞增殖、治疗伤口、治疗凋亡或在细胞、组织或器官中保护或恢复功能、培养细胞、保护器官或组织功能，以及治疗皮肤病理条件。
• [EN] CONTINUOUS PROCESS FOR THE PRODUCTION OF DERIVATIVES OF SATURATED CARBOXYLIC ACIDS<br/>[FR] PROCÉDÉ CONTINU DE PRODUCTION DE DÉRIVÉS D'ACIDES CARBOXYLIQUES SATURÉS
  申请人：NOVAMONT SPA

  公开号：WO2011080297A1

  公开（公告）日：2011-07-07

  There is described a continuous process for the oxidative cleavage of derivatives of unsaturated carboxylic acids for the production of saturated carboxylic acids and their derivatives comprising the steps of: a) feeding to a first reactor at least a derivative of an unsaturated carboxylic acid, an oxidizing compound and a catalyst capable of catalyzing the oxidation reaction of the olefinic double bond to obtain an intermediate compound containing vicinal diols, and of b) feeding to a second reactor said intermediate compound, a compound containing oxygen and a catalyst capable of catalyzing the oxidation reaction of the vicinal diols to carboxylic groups, to obtain saturated monocarboxylic acids (i) and derivatives of saturated carboxylic acids with more than one acid function (ii); c) separating the saturated monocarboxylic acids (i) from the derivatives of carboxylic acids having more than one acid function (ii).

  描述了一种连续的过程，用于氧化裂解不饱和羧酸衍生物，生产饱和羧酸及其衍生物，包括以下步骤：a）将至少一种不饱和羧酸衍生物、氧化剂和能够催化烯烃双键氧化反应的催化剂输入到第一反应器中，以获得含有邻二醇的中间化合物；b）将所述中间化合物、含氧化合物和能够催化邻二醇氧化为羧基的催化剂输入到第二反应器中，以获得饱和单羧酸（i）和具有多个酸功能的饱和羧酸衍生物（ii）；c）将饱和单羧酸（i）与具有多个酸功能的羧酸衍生物（ii）分离。
• CONTINUOUS PROCESS FOR THE PRODUCTION OF DERIVATIVES OF SATURATED CARBOXYLIC ACIDS
  申请人：Bieser Arno

  公开号：US20120302778A1

  公开（公告）日：2012-11-29

  There is described a continuous process for the oxidative cleavage of derivatives of unsaturated carboxylic acids for the production of saturated carboxylic acids and their derivatives comprising the steps of: a) feeding to a first reactor at least a derivative of an unsaturated carboxylic acid, an oxidizing compound and a catalyst capable of catalyzing the oxidation reaction of the olefinic double bond to obtain an intermediate compound containing vicinal diols, and of b) feeding to a second reactor said intermediate compound, a compound containing oxygen and a catalyst capable of catalyzing the oxidation reaction of the vicinal diols to carboxylic groups, to obtain saturated monocarboxylic acids (i) and derivatives of saturated carboxylic acids with more than one acid function (ii); c) separating the saturated monocarboxylic acids (i) from the derivatives of carboxylic acids having more than one acid function (ii).

  描述了一种连续过程，用于氧化裂解不饱和羧酸衍生物以生产饱和羧酸及其衍生物，包括以下步骤：a）将至少一种不饱和羧酸衍生物、氧化剂和能够催化烯丙双键氧化反应的催化剂送入第一反应器，以获得含有邻二醇的中间化合物，和b）将所述中间化合物、含氧化合物和能够催化邻二醇氧化为羧基的催化剂送入第二反应器，以获得饱和单羧酸（i）和具有多个酸功能的饱和羧酸衍生物（ii）；c）将饱和单羧酸（i）与具有多个酸功能的羧酸衍生物（ii）分离。
• Beta2-Adrenergic Receptor Agonists
  申请人：Moran Edmund J.

  公开号：US20080269344A1

  公开（公告）日：2008-10-30

  Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.

  本发明涉及多结合化合物，其是β2肾上腺素能受体激动剂，可用于治疗和预防哮喘、支气管炎等呼吸系统疾病。它们还可用于治疗神经系统损伤和早产。
• CELLULOSE RESIN AND METHOD FOR PRODUCING THE SAME
  申请人：Iji Masatoshi

  公开号：US20120196998A1

  公开（公告）日：2012-08-02

  A cellulose resin produced by binding cardanol or a derivative thereof and abietic acid or a derivative thereof to cellulose or a derivative thereof.

  一种由将腺酚或其衍生物与松香酸或其衍生物与纤维素或其衍生物结合而产生的纤维素树脂。